Abstract:
:Insulin binding and 3-0-Methylglucose transport have been studied in erythrocyte- and reticulocyte-enriched fractions of blood cells in order to determine if the increased number of insulin binding sites in reticulocytes is associated with a glucose transport response to insulin. In these experiments rabbit reticulocytes demonstrate an eightfold increase in total insulin receptors when compared to erythrocytes. Glucose transport activity in the erythrocyte has Km of 3.2 mM. Reticulocytes demonstrate a saturable glucose transport activity of lower affinity, Km 18.9 mM. Neither the erythrocyte, nor the the reticulocyte glucose transport activity, was capable of an increased response to insulin. the low affinity glucose transport activity in reticulocytes could allow a fourfold increase in facilitated glucose transport at supraphysiological glucose concentrations that might occur in poorly controlled diabetes mellitus.
journal_name
Life Scijournal_title
Life sciencesauthors
Albert SGdoi
10.1016/0024-3205(82)90588-4subject
Has Abstractpub_date
1982-07-19 00:00:00pages
265-71issue
3eissn
0024-3205issn
1879-0631pii
0024-3205(82)90588-4journal_volume
31pub_type
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