Abstract：
:Biphasic cutaneous reaction with peak response at 1 (early phase) and 24 to 48 hour (late phase) was elicited by epicutaneous challenge with antigen in actively and passively sensitized mice. Mice were actively immunized with dinitrophenylated (DNP) ascaris antigen and challenged with dinitrofluorobenzene (DNFB). Passively sensitization was carried out by the injection of monoclonal anti-DNP-IgE antibody into mice and challenge was elicited with DNFB. Prednisolone at doses of 3 to 10 mg/kg clearly inhibited both early and late phase reactions in either sensitized mice. Monoclonal anti-tumor necrosis factor (TNF)-alpha antibody inhibited the late phase cutaneous reaction in actively sensitized mice. Anti-interleukin-5 (IL-5) monoclonal antibody has no effect on both phase reactions in either actively and passively sensitized animals. These results indicate the possible participation of TNF-alpha in allergic cutaneous late phase reaction in actively sensitized mice.
journal_name
Life Scijournal_title
Life sciencesauthors
Sakurai T,Inagaki N,Nagai Hdoi
10.1016/0024-3205(94)00859-0subject
Has Abstractpub_date
1994-01-01 00:00:00pages
PL291-5issue
17eissn
0024-3205issn
1879-0631pii
0024-3205(94)00859-0journal_volume
54pub_type
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