Abstract：
:The purpose of this study was to characterize behavioral interactions between glutamatergic and serotonergic 5-HT2 receptors. Both competitive (AP-5 [D-2-amino-5-phosphovalerate] and D-CPP [3-(2carboxypiperazine-4yl)-propylphosphonate]) and noncompetitive (MK-801 [dizocilpine], ketamine, dextrorphan and dextromethorphan) N-methyl-D-aspartate (NMDA) receptor antagonists markedly enhanced a selective serotonergic behavior, the head twitch response (HTR), in mice. In contrast, NMDA itself inhibited 5-hydroxytryptamine (5-HT)-induced HTR in mice. These results suggest that glutamatergic neurotransmission may modulate serotonergic function at the 5-HT2 receptor.
journal_name
Life Scijournal_title
Life sciencesauthors
Kim HS,Park IS,Park WKdoi
10.1016/s0024-3205(98)00519-0subject
Has Abstractpub_date
1998-01-01 00:00:00pages
2305-11issue
26eissn
0024-3205issn
1879-0631pii
S0024320598005190journal_volume
63pub_type
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