Abstract：
:In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper. We examined here the effect of nerve growth factor (NGF) on the antigen-specific antibody production in vitro augmented by AA-2G. NGF (> or = 10 ng/ml), which alone had no effect, enhanced the anti-sheep-red-blood-cell (SRBC) antibody response stimulated by AA-2G. The effect of NGF plus AA-2G or AA-2G alone was abrogated by the presence of castanospermine, an alpha-glucosidase inhibitor, suggesting that the active form of AA-2G is ascorbate. The repeated additions; but not one addition, of ascorbate also resulted in a synergism with NGF on the antibody production. These results suggest that NGF might be a cytokine which functions as a regulatory factor for ascorbate-dependent immune responses.
journal_name
Life Scijournal_title
Life sciencesauthors
Yanagida M,Gohda E,Yamamoto Idoi
10.1016/s0024-3205(96)00561-9subject
Has Abstractpub_date
1996-01-01 00:00:00pages
2075-81issue
24eissn
0024-3205issn
1879-0631pii
S0024320596005619journal_volume
59pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:A completely randomized controlled study based on a rabbit model was designed to study the effect of repetitive ischemic preconditioning (IPC) on a spinal cord ischemic reperfusion injury. Twenty four white adult Japanese rabbits were randomly assigned to one of the 3 groups (n = 8 per group): Group I: sham-operation ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.04.014
更新日期：2006-09-05 00:00:00
abstract：:This investigation was undertaken to characterize the muscarinic receptor subtypes involved in methacholine-induced vasodilation, vagal bradycardia, neurally-evoked sudomotor responses and sympathetic muscarinic ganglionic transmission in anesthetized cats. Dose-response curves were constructed using the putatively se...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00376-7
更新日期：1997-01-01 00:00:00
abstract：:The central interference induced by dexamethasone and RU-38486, (a glucocorticoid receptor antagonist) on morphine antinociception were studied by using the tail flick test in mice. Dexamethasone, injected intracerebrally (i.c.v.) 10 minutes before morphine, dose-dependently reduced morphine antinociception, whereas R...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90521-p
更新日期：1992-01-01 00:00:00
abstract：:The purpose of the this study was to characterize the putative anxiolytic-like effects of the aqueous extract of Albizzia julibrissin stem bark using the elevated plus maze (EPM) in rats. The water extract of Albizzia julibrissin was orally administered at 10, 50, 100 or 200 mg/kg to adult male SD rats, 1 h before beh...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.05.024
更新日期：2004-10-22 00:00:00
abstract：:We analyzed PGE2 production in primary-cultured human hepatic macrophages (HHM phi) and peripheral monocytes (MO) from patients with and without liver cirrhosis, and correlated PGE2 production with the patients' liver function. Serum choline esterase (ChE) levels were used as an indicator of liver function. PGE2 produ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90751-n
更新日期：1993-01-01 00:00:00
abstract：AIMS:GnRH-DFF40 (gonadotropin releasing hormone-DNA fragmentation factor 40) humanized recombinant immunotoxin serves as a prospective candidate for targeted therapy of malignancies with over-expressed gonadotropin releasing hormone receptor (GnRHR). In this study, we attempted to generate a GnRH-based chimeric protein...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118866
更新日期：2021-01-15 00:00:00
abstract：:Endogenous dopamine (DA) and norepinephrine (NE) in the superfusate from slices of rat medial prefrontal cortex were measured by high-performance liquid chromatography coupled to electrochemical detection (HPLC-ECD). Stimulation with high K+ or methamphetamine (MAP) evoked a dose-dependent elevation in the release of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90356-g
更新日期：1991-01-01 00:00:00
abstract：:Increasing understanding in tumor pathology reveals that tumor microenvironment (TME), which supports tumor progression and poses barriers for available therapies, takes a great responsibility in inefficient treatment and poor prognosis. In recent years, the versatile nanotechnology employed in TME regulation has made...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.03.044
更新日期：2018-05-15 00:00:00
abstract：:A single intravenous injection of alloxan in mice induced hyperglycemia in a dose dependent fashion. This diabetogenic action of alloxan was prevented by a single intraperitoneal injection of the alpha 2-adrenergic agonists, i.e. oxymetazoline, clonidine or epinephrine 40 min prior to the injection of alloxan. The alp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90301-6
更新日期：1983-02-14 00:00:00
abstract：:The effects of naloxone, an opiate "pure" receptor antagonist, on the release of prolactin and corticosterone in the rat were studied following the administration of the serotonin precursor 5-hydroxytryptophan or the serotonin receptor agonist (-) -m-chlorophenylpiperazine. Naloxone clearly antagonizes the release of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90367-3
更新日期：1983-05-23 00:00:00
abstract：:Nephrotoxicity is a limiting factor in the use of ifosfamide in children. Despite the co-administration of uroprotective agents such as sodium 2-mercaptoethanesulfonate (mesna), ifosfamide chemotherapy is associated with nephropathy characterized by glomerular toxicity and Fanconi syndrome in many children treated wit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00915-2
更新日期：2000-11-24 00:00:00
abstract：:Preliminary data suggest that amygdalar corticotropin-releasing factor (CRF) is regulated by nicotinic agonists. We sought to confirm and extend these observations by determining the effects of various concentrations of nicotine on CRF messenger RNA expression in the AR-5 immortalized amygdalar cell line. Nicotine pro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00539-1
更新日期：1999-01-01 00:00:00
abstract：:Although nitrosation plays an important role in initiation of carcinogenesis, the reactive nitrogen oxygen species (RNOS) mediating this reaction by multiple pathways have not been determined. The heterocyclic amine carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was used as a target to investigate RNOS and pa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.10.010
更新日期：2007-01-23 00:00:00
abstract：:The role of alpha 1-adrenoceptors in the mediation of autonomic functions, particularly in the control of the cardiovascular system, is widely known. It has been shown that alpha 1-adrenoceptors localized in human prostate mediate the contraction of prostatic smooth muscles which produces an increase in the intraureth...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(94)90141-4
更新日期：1994-01-01 00:00:00
abstract：:The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intraveno...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.06.013
更新日期：2008-08-15 00:00:00
abstract：:The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02067-s
更新日期：1995-01-01 00:00:00
abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117703
更新日期：2020-07-15 00:00:00
abstract：AIMS:Endothelin A receptor (ET(A)R) and epidermal growth factor receptor (EGFR) cross-talk enhances the metastatic potential of epithelial ovarian cancer (EOC) cells activating different pathways, including β-catenin signalling. Here, we evaluated β-catenin as one of ET(A)R/EGFR downstream pathway in the invasive behav...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.03.023
更新日期：2012-10-15 00:00:00
abstract：:NMDA receptors are glutamate-regulated ion channels of critical importance for many neurophysiological and neuropathological processes. Mg2+ blocks the NMDA receptor by binding to the channel pore with an apparent affinity that depends on the membrane potential. We have investigated the effect of NMDA and the required...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)00975-4
更新日期：2001-03-09 00:00:00
abstract：:The aim of this study was to investigate the effects of cyclosporin (CyA) treatment on biliary glutathione efflux in rats of different ages (1, 2, 4, and 24 months). CyA treatment reduced the liver content of total glutathione in 1-, 2- and 24 month old rats (-30%, -43% and -30%, respectively). By contrast, oxidized g...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.06.019
更新日期：2003-11-14 00:00:00
abstract：AIMS:This study aimed to design and screen a dual functional fusion peptide that could penetrate the blood-brain barrier and target neuropilin 1 (NRP1) overexpressed in vascular endothelial cells for the anti-angiogenesis of glioma treatment. MAIN METHODS:At the cellular level, the in vitro anti-angiogenic activity of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119113
更新日期：2021-01-27 00:00:00
abstract：:The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00495-e
更新日期：1995-01-01 00:00:00
abstract：:Serotonin (5HT) stimulates phosphoinositide turnover in a number of tissues, but it is not known whether this effect is due to activation of a 5HT receptor which is coupled to phosphoinositide hydrolysis or if the effect is secondary to 5HT stimulated arachidonate metabolism or to the release of another neurotransmitt...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90060-3
更新日期：1986-02-17 00:00:00
abstract：:The validity of a photoelectric method for continuous cerebral blood volume (CBV) measurement was tested and modified for the rat's brain. A new way of introducing a miniature light source between the two hemispheres and fixing a light sensitive silicone blue cell to the outer surface of the parietal bone was develope...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90163-3
更新日期：1986-11-03 00:00:00
abstract：:Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circul...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90016-7
更新日期：1989-01-01 00:00:00
abstract：:Adult female Sprague-Dawley rats were prepared with permanent cortical EEG and temporalis EMG electrodes and i.v. cannulae. They were made tolerant to and physically dependent on morphine by automatic, hourly injections. These physically dependent rats were then trained to lever press for 10 mg/kg injections of morphi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90564-7
更新日期：1983-01-01 00:00:00
abstract：:The effect of adrenergic agents on protein phosphorylation in human adipocytes was examined. Freshly isolated human fat cells were incubated with 32PO4 in order to label intracellular ATP, then treated with a variety of adrenergic and other pharmacologic agents. Treatment with the beta-adrenergic agonist isoproterenol...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90597-k
更新日期：1990-01-01 00:00:00
abstract：:The effect of oral administration of Clostridium butyricum Miyairi on the formation and dissolution of gallstones was examined in a mouse model of cholesterol cholelithiasis, in comparison with that of chenodeoxycholic acid (CDCA). A diet containing cholesterol and sodium cholate was used as a lithogenic diet. The fee...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90149-2
更新日期：1983-01-31 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide. It is a lethal and progressive neurodegenerative disease, principally affecting motor neurons; patient clinical characteristics are muscle weakness, dysphagia and respiratory failure. The mean age is related to family history (4...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2017.12.016
更新日期：2018-01-15 00:00:00
abstract：AIMS:This study aims to investigate the value of the expression of miR-208, miR-494, miR-499 and miR-1303 in the early diagnosis of acute myocardial infarction (AMI). MAIN METHODS:Patients were divided into two groups: AMI group (n = 41), and Stable angina pectoris (SAP) group (n = 32). Peripheral venous blood was sam...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116547
更新日期：2019-09-01 00:00:00
