Abstract：
:Sorbitol levels in heart were determined in streptozotocin-induced diabetic rats. Significantly higher levels were found in hearts of diabetic rats compared to normal rats. The findings are compatible with either significantly higher de novo synthesis of sorbitol in heart than is generally believed or uptake of circulating sorbitol by heart as previously indicated by nuclear magnetic resonance (NMR) in vivo metabolic imaging. Sorbitol accumulation in heart tissue may play a role in the pathogenesis of diabetic cardiomyopathy as has been implicated in cataract formation.
journal_name
Life Scijournal_title
Life sciencesauthors
Nakada T,Kwee ILdoi
10.1016/0024-3205(89)90016-7subject
Has Abstractpub_date
1989-01-01 00:00:00pages
2491-3issue
25eissn
0024-3205issn
1879-0631pii
0024-3205(89)90016-7journal_volume
45pub_type
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