The influence of testosterone administration on plasma prolactin levels in the neonatally androgenized (NA) female rat.

abstract：AIMS:The natural phenolic oil compound hydroxytyrosol (HTy) is widely studied because of its antioxidant and neuroprotective properties. Nitroderivatives of HTy have been studied in order to evaluate their putative effects on catechol-O-methyltransferase (COMT) activity. MAIN METHODS:To study its effect on dopamine me...

journal_title：Life sciences

authors： Gallardo E,Madrona A,Palma-Valdés R,Espartero JL,Santiago M

更新日期：2015-08-01 00:00:00

abstract：:The leukotriene (LT) synthesis inhibitors BAY x1005 and MK-886 were evaluated in human lung parenchyma challenged with an anti-IgE. The anti-IgE-induced LTE4 release was time- and dose-dependent. Treatment of the parenchyma with indomethacin (3 microM) prior to anti-IgE challenge inhibited the 6-keto prostaglandin F1 ...

journal_title：Life sciences

authors： Gorenne I,Alaoui HS,Gascard JP,Labat C,Norel X,De Montpreville V,Brink C

更新日期：1996-01-01 00:00:00

abstract：:Heart rate (HR) and mean arterial blood pressure (BP) were recorded from conscious, chair-restrained squirrel monkeys surgically prepared with chronically indwelling arterial and venous catheters to determine the effects of acute intravenous injections of two opiate antagonists and an agonist. Naloxone (0.3--10.0 mg/k...

journal_title：Life sciences

authors： Byrd LD

更新日期：1983-01-24 00:00:00

abstract：AIMS:Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease. MAIN METHODS:We collected platelet-poor plas...

journal_title：Life sciences

authors： Li B,Huang Q,Lin C,Lu R,Wang T,Chen X,Liu Z,Liu Y,Wu J,Wu Y,Liao S,Ding X

更新日期：2021-01-15 00:00:00

abstract：:The biochemical changes of the elements of cholinergic neurotransmission (choline acetyltransferase, ChAT; acetylcholinesterase, AChE; butyrylcholinesterase, BuChE; and muscarinic cholinergic receptors, mAChR) as well as the electrolyte content were studied in ischemic lumbar spinal cord segments of newborn pigs. Isch...

journal_title：Life sciences

authors： Tekulics P,Rakonczay Z,Szerdahelyi P,Kása P,Gulya K

更新日期：1990-01-01 00:00:00

abstract：:To investigate whether endogenous opioid peptides mediate time-dependent changes in ventilatory control during prolonged hypoxia, we studied four adult goats at rest during 14 days at simulated high altitude in a hypobaric chamber (PB approximately 450 Torr). Arterial PCO2 fell during the first several hours of hypoxi...

journal_title：Life sciences

authors： Weinberger SE,Steinbrook RA,Carr DB,Fencl V,Gabel RA,Leith DE,Fisher JE,Harris R,Rosenblatt M

更新日期：1987-02-16 00:00:00

abstract：AIMS:Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aer...

journal_title：Life sciences

authors： Tanahashi K,Akazawa N,Miyaki A,Choi Y,Ra SG,Matsubara T,Kumagai H,Oikawa S,Miyauchi T,Maeda S

更新日期：2014-07-11 00:00:00

abstract：:The available preclinical literature on the antihyperlipidemic properties of beta-pyridylcarbinol is reviewed. Similarities between the pharmacological profiles for beta-pyridylcarbinol and nicotinic acid, and evidence for the metabolic conversion of beta-pyridylcarbinol to nicotinic acid are discussed. Several review...

journal_title：Life sciences

authors： Cohen M

更新日期：1985-11-25 00:00:00

abstract：:Phenol sulfotransferase (PST, EC 2.8.2.1) and glutathione-S-transferase (GST, EC 2.5.1.18), the phase II biotransformation enzymes inactivate many exo- and endogenous compounds. The effect of PST substrates (catecholamines, simple phenols, selected phenolic drugs) and PST products (phenolic sulfates) on GST activity w...

journal_title：Life sciences

authors： Baranczyk-Kuzma A,Sawicki J

更新日期：1997-01-01 00:00:00

abstract：:Uric acid values in serum have been analyzed as one of the markers to predict cellular damage due to ischemia reperfusion injury in the field of organ transplantation. The present study was conducted to confirm that uric acid values in serum could be an efficient marker of ischemic injury of liver parenchyma following...

journal_title：Life sciences

authors： Kogure K,Ishizaki M,Nemoto M,Kuwano H,Tatemoto K,Maruyama Y,Ikarashi Y,Makuuchi M

更新日期：1999-01-01 00:00:00

abstract：:Extracts of brain and heart from rats at birth and postnatal days 2 and 10 were evaluated for naltrexone following maternal injection of 50 mg/kg opioid antagonist throughout gestation. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed-phase high performanc...

journal_title：Life sciences

authors： Zagon IS,Hurst WJ,McLaughlin PJ

更新日期：1998-01-01 00:00:00

abstract：:The objective of the present study was to investigate the roles of protein kinase A and/or C in agonist-induced beta adrenoceptor activation in intact human lymphocytes. LYmphocytes from healthy subjects were incubated with isoproterenol and phosphodiesterase inhibitor (IBMX, 1.0 mM) after 20 minutes of preincubation ...

journal_title：Life sciences

authors： Hui KK,Yu JL

更新日期：1990-01-01 00:00:00

abstract：:Neuropeptide Y (NPY) was found in high concentrations in the male genital tract. NPY levels were highest in the seminal vesicles, prostate, corpus cavernosum and vas deferens, where large numbers of immunoreactive nerve fibres were detected. Considerable quantities were also found in the epididymis and spongiosum. Low...

journal_title：Life sciences

authors： Adrian TE,Gu J,Allen JM,Tatemoto K,Polak JM,Bloom SR

更新日期：1984-12-24 00:00:00

abstract：AIMS:To investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) on cognitive dysfunction, the expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and amyloid β peptide (Aβ) in the hippocampus, as well as dendritic pathology in the hippocampal CA1 region in sepsis-associate...

journal_title：Life sciences

authors： Zhong J,Guo C,Hou W,Shen N,Miao C

更新日期：2019-10-15 00:00:00

abstract：:beta-Adrenergic agonists used in therapy of premature labor and asthma cross the placenta and can affect development of the fetal nervous system. In the current study, pregnant rats were given 10 mg/kg of terbutaline on gestational days 17, 18 and 19 and adrenergic receptor binding capabilities examined in brain regio...

journal_title：Life sciences

authors： Slotkin TA,Kudlacz EM,Lappi SE,Tayyeb MI,Seidler FJ

更新日期：1990-01-01 00:00:00

abstract：:The study was designed to investigate the role of molybdenum iron-sulfur flavin hydroxylases in the pathogenesis of liver injuries induced by structurally and mechanistically diverse hepatotoxicants. While carbon tetrachloride (CCl4), thioacetamide (TAA) and chloroform (CHCl3) inflict liver damage by producing free ra...

journal_title：Life sciences

authors： Ali S,Pawa S,Naime M,Prasad R,Ahmad T,Farooqui H,Zafar H

更新日期：2008-03-26 00:00:00

abstract：:Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect ...

journal_title：Life sciences

authors： Oghbaei H,Rastgar Rezaei Y,Nikanfar S,Zarezadeh R,Sadegi M,Latifi Z,Nouri M,Fattahi A,Ahmadi Y,Bleisinger N

更新日期：2020-09-01 00:00:00

abstract：:Estrogen has diverse effects on the vasculature, such as vasodilation, endothelial growth and inhibition of vascular smooth muscle cell (VSMC) proliferation and migration. However, little is known about the genes that are regulated by estrogen in the vascular wall. Wistar rats were ovariectomized or sham-operated (Sha...

journal_title：Life sciences

authors： Watanabe T,Akishita M,Nakaoka T,He H,Miyahara Y,Yamashita N,Wada Y,Aburatani H,Yoshizumi M,Kozaki K,Ouchi Y

更新日期：2004-07-23 00:00:00

abstract：:The melanocortins are a family of bioactive peptides derived from proopiomelanocortin. Those peptides, included among hormones and comprising ACTH, alpha-MSH, beta-MSH and gamma-MSH, are best known mainly for their physiological effects, such as the control of skin pigmentation by alpha-MSH, and ACTH effects on pigmen...

journal_title：Life sciences

authors： Starowicz K,Przewłocka B

更新日期：2003-07-04 00:00:00

abstract：:The induction of aldose reductase (AR) mRNA expression and its activity by glucose were investigated in fetal rat aortic smooth muscle (A10) cells. The increase in the expression of AR mRNA was observed at 6 h, and reached a maximum (2.3 fold) at 12 h after exposure to 80 mM glucose. On the other hand, increase in AR ...

journal_title：Life sciences

authors： Tawata M,Ohtaka M,Hosaka Y,Onaya T

更新日期：1992-01-01 00:00:00

abstract：:Kinin release and its involvement in inflammatory exudation were assessed by immuno-blot analysis of the kinin-precursor protein, high molecular weight kininogen (HK). HK consists of heavy (H) chain, bradykinin and light (L) chain. After bradykinin was released by plasma kallikrein, HK remains two-chain-kinin-free for...

journal_title：Life sciences

authors： Fujie H,Hayashi I,Oh-ishi S

更新日期：1993-01-01 00:00:00

abstract：:The number of GABAergic neurons as determined by GAD immunocytochemistry and total neurons as determined from Nissl preparations were counted and classified at the light microscopic level in the inferior colliculus (IC) of the genetically epilepsy prone rat (GEPR) and the non-epileptic Sprague-Dawley (SD) strain of ra...

journal_title：Life sciences

authors： Roberts RC,Ribak CE

更新日期：1986-09-01 00:00:00

abstract：AIMS:The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)-induced renal tubulointerstitial injury. This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism. MAIN METHODS:Diabetes w...

journal_title：Life sciences

authors： Zha D,Yao T,Bao L,Gao P,Wu X

更新日期：2019-03-15 00:00:00

abstract：:Alpha adrenergic receptors are identified on basolateral plasma membranes derived from proximal tubular epithelial cells. The density of alpha 2 receptors was over two-fold greater than alpha 1 receptors. The basolateral membranes were devoid of beta receptors. These results support previous demonstrations of alpha ad...

journal_title：Life sciences

authors： Jensen RE,Berndt WO

更新日期：1988-01-01 00:00:00

abstract：:A series of studies were conducted to determine the effects of leucine-(leu-) enkephalin and methionine-(met-) enkephalin on perfusion pressure. These experiments utilized isolated perfused femoral arterial preparations in pentobarbital-anesthetized cats. The enkephalins were administered intraarterially into the femo...

journal_title：Life sciences

authors： Moore RH 3rd,Dowling DA

更新日期：1982-10-11 00:00:00

abstract：AIMS:Osteoclasts, the unique bone-resorbing polykaryons, are responsible for many bone-destructive diseases, such as osteoporosis and rheumatoid arthritis. Hence, the regulation of osteoclast formation is considered a potential therapeutic approach for these diseases. In this study, we investigated the effect of a nove...

journal_title：Life sciences

authors： Kim HJ,Yoon KA,Lee MK,Kim SH,Lee IK,Kim SY

更新日期：2012-11-02 00:00:00

abstract：:Tumor angiogenesis and lymphangiogenesis are key features of tumor progression and metastasis. The role of tumor cells-derived factors in the promotion of associated angiogenesis and lymphangiogenesis is much studied and, no doubt, very important for the understanding of cancer progression. This review aims to present...

journal_title：Life sciences

authors： Gomes FG,Nedel F,Alves AM,Nör JE,Tarquinio SB

更新日期：2013-02-07 00:00:00

abstract：:Diabetes Mellitus (DM) can produce an increase in the cardiac action potential duration and QT interval that can be associated with sudden death. These cardiac effects are due to a region-specific decrease in repolarizing outward K(+) currents. Some authors have suggested that the proarrhythmic effects of diabetes can...

journal_title：Life sciences

authors： Ferrer T,Gallego M,Madrigal-Quiñónez R,Torres-Jácome J,Navarro-Polanco R,Cásis O,Sánchez-Chapula JA

更新日期：2006-07-24 00:00:00

abstract：:The binding of 3H-ouabain to human erythrocytes was analyzed in a population of hospitalized male ethanol addicted patients under long term digitalis treatment. In the non-alcoholic patient group the long term digitalis treatment induced an increase in Bmax and Kd values; such modification was not observed in the alco...

journal_title：Life sciences

authors： Battaini F,Govoni S,Mauri A,Civelli L,Trabucchi M

更新日期：1987-06-29 00:00:00

abstract：:In rats with a unilateral 6-OHDA lesion of the substantia nigra exposure to footshock or immobilization stress produced a long-lasting enhancement in the rotational behavior evoked by a subsequent injection of amphetamine. However, the effect was dependent on the environmental context in which stress was applied. It i...

journal_title：Life sciences

authors： Robinson TE,Angus AL,Becker JB

更新日期：1985-09-16 00:00:00