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Prostaglandin E2 production by hepatic macrophages and peripheral monocytes in liver cirrhosis patients.

Abstract：

:We analyzed PGE2 production in primary-cultured human hepatic macrophages (HHM phi) and peripheral monocytes (MO) from patients with and without liver cirrhosis, and correlated PGE2 production with the patients' liver function. Serum choline esterase (ChE) levels were used as an indicator of liver function. PGE2 production in both HHM phi and MO from cirrhotic patients was significantly lower than in HHM phi and MO from non-cirrhotic patients. PGE2 production in cirrhotic HHM phi was inversely correlated with ChE levels, whereas PGE2 production in cirrhotic MO showed no obvious correlation. In conclusion, both HHM phi and MO might contribute to the pathophysiology of liver cirrhosis via attenuated PGE2 production. Furthermore, HHM phi activity appears to be more strongly affected by the chronic pathological changes observed in the cirrhotic liver.

journal_name

Life Sci

journal_title

Life sciences

authors

Funaki N,Arii S,Adachi Y,Higashituji H,Tanaka J,Imamura M

doi

10.1016/0024-3205(93)90751-n

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

323-31

issue

4

eissn

0024-3205

issn

1879-0631

pii

0024-3205(93)90751-N

journal_volume

53

pub_type

杂志文章

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