Abstract：
:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visualized diffusely over rat striatum. Ligand selectivity analysis suggested that the Type 2 opiate binding site is equivalent to a delta opiate receptor. The auto-radiographic distribution of Type 2 opiate binding sites is diffuse over most areas of rat brain. Thus, Type 2 opiate binding sites are different from Type 1 opiate receptors which are very discretely distributed in rat brain. Our results suggest that Type 2 opiate receptors, unlike Type 1 opiate receptors, are receptors locked in a delta-like ligand selectivity conformation.
journal_name
Life Scijournal_title
Life sciencesauthors
Olgiati V,Quirion R,Bowen WD,Pert CBdoi
10.1016/0024-3205(82)90183-7subject
Has Abstractpub_date
1982-10-18 00:00:00pages
1675-8issue
16-17eissn
0024-3205issn
1879-0631pii
0024-3205(82)90183-7journal_volume
31pub_type
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