Abstract：
:Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline. Nitric oxide causes efflux of non-heme iron from neoplastic and infected host cells. In the absence of L-arginine, IFN-gamma-induced infected cells can lower their net uptake of iron. Cellular depletion of the metal via either mechanism suppresses DNA synthesis as well as the functioning of aerobic respiratory enzymes. Macrophage regulation of growth of other host cells during embryogenesis, immune responses, or immunosurveillance might involve iron depletion.
journal_name
Life Scijournal_title
Life sciencesauthors
Weinberg EDdoi
10.1016/0024-3205(92)90279-xsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
1289-97issue
18eissn
0024-3205issn
1879-0631pii
0024-3205(92)90279-Xjournal_volume
50pub_type
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