Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes.

abstract：:In order to investigate the action of ethanol on the anterior pituitary gland, the effect of ethanol on prolactin secretion in vitro was studied. Ethanol significantly increased the in vitro incorporation of 3H-leucine into both prolactin contained within the pituitary gland and that released into the medium. The enha...

journal_title：Life sciences

authors： Seilicovich A,Duvilanski BH,Debeljuk L,Díaz MC,Muñoz Maines V,Rettori V

更新日期：1984-11-05 00:00:00

abstract：:Carboxylesterase activity (EC 3.1.1.1) of hen brain including neurotoxic esterases NTEA and NTEB is solubilized from lyophilized lipid-extracted brain material by the use of n-octylglucoside. The solubilized enzymes are subjected to free isoelectric focusing, six carboxyl - esterase activity peaks are obtained. By gel...

journal_title：Life sciences

authors： Chemnitius JM,Haselmeyer KH,Zech R

更新日期：1984-03-19 00:00:00

abstract：UNLABELLED:Limited clinical and experimental studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit gastric cancer growth. However, the mechanisms involved are not completely understood and cannot be explained by COX-2 inhibition alone. MAPK signaling pathway is essential for cell proliferation...

journal_title：Life sciences

authors： Husain SS,Szabo IL,Pai R,Soreghan B,Jones MK,Tarnawski AS

更新日期：2001-11-09 00:00:00

abstract：:In rodents an action of estrogen is required for the initiation of implantation of the blastocyst into the endometrium of a progesterone-primed uterus. Thus removal of endogenous estrogen, either directly by ovariectomy or indirectly by hypophysectomy, prevents implantation in the pregnant rat. In the present study, d...

journal_title：Life sciences

authors： Johnson DC

更新日期：1996-01-01 00:00:00

abstract：:The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...

journal_title：Life sciences

authors： Pertwee RG

更新日期：1999-01-01 00:00:00

abstract：AIMS:Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period. MAIN METHODS:A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into ...

journal_title：Life sciences

authors： Yu YL,Li NN,Shi MT,Lu HJ

更新日期：2018-09-15 00:00:00

abstract：:Our previous biochemical and mechanical studies have demonstrated an increase in Ca2+ sensitivity of cardiac myofilaments in ovariectomized rats. To test whether the body weight gain associated with ovariectomy contributed some effects to the changes in myofibrillar functions, the relations of pCa (-log Ca2+ molar con...

journal_title：Life sciences

authors： Wattanapermpool J,Riabroy T,Preawnim S

更新日期：2000-01-01 00:00:00

abstract：:We observed a significant increase in plasma atrial natriuretic factor (ANF) in antiorthostatic hypokinetic suspension (AOH) rats after 2 h of suspension when the experiment was made during day. Plasma ANF was investigated in relation to renal glomerular ANF receptors during AOH at night. The aim of this study was 1) ...

journal_title：Life sciences

authors： Gauquelin G,Schiffrin EL,Garcia R,Entresangles M,Cantin M,Gharib C

更新日期：1988-01-01 00:00:00

abstract：:The effect of Rp diastereoisomer of adenosine 3',5'-cyclic monophosphothioate (Rp-cAMPS) on relaxation elicited by histamine (1-100 microM), forskolin (1-60 microM), papaverine (1-100 microM), vinpocetine (1-100 microM), rolipram (0.1-1 mM), Sp-cAMPS (10-300 microM), 8-BrcAMP (10 microM - 1 mM) and 8-BrcGMP (3 microM ...

journal_title：Life sciences

authors： Perez-Vallina JR,Revuelta MP,Cantabrana B,Hidalgo A

更新日期：1997-01-01 00:00:00

abstract：AIMS:Bisphenol (BP)-A exposure can impair glucose and lipid metabolism. However, it is unclear whether this endocrine disruptor (ED) modulates these processes in postmenopause, a period with organic changes that increase the risk for metabolic diseases. Herein, we evaluated the effects of BPA exposure on adiposity, glu...

journal_title：Life sciences

authors： Figueiredo LS,Oliveira KM,Freitas IN,Silva JA Jr,Silva JN,Favero-Santos BC,Bonfleur ML,Carneiro EM,Ribeiro RA

更新日期：2020-09-01 00:00:00

abstract：:Elevated total homocysteine concentrations and obesity are both associated with an increased risk of cardiovascular disease. However, previous studies of weight reduction on serum homocysteine concentrations have obtained inconsistent reports. We investigated the effect of folic acid supplementation on serum homocyste...

journal_title：Life sciences

authors： Sheu WH,Chin HM,Lee WJ,Wan CJ,Su HY,Lang HF

更新日期：2005-03-18 00:00:00

abstract：:The sphincter of Oddi (SO) plays an important role in regulating the bile flow into the duodenum. This study was designed to investigate the effect of Chinese Medicinal Herbs Muh-Shiang-Bin-Lang-Wan (MSBLW) and their mechanism of action on regulating the motility of SO in rabbits. The activity of SO in anesthetized ra...

journal_title：Life sciences

authors： Kuo YI,Chiu JH,Lin JG,Hsieh CL,Wu CW

更新日期：2003-12-12 00:00:00

abstract：AIMS:Cisplatin is an anticancer agent marred by nephrotoxicity. Limiting this adverse effect may allow the use of higher doses to improve its efficacy. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis and repair of renal diseases. BIO, a small molecule agonist of this pathway, exerted a protec...

journal_title：Life sciences

authors： Sun Z,Xu S,Cai Q,Zhou W,Jiao X,Bao M,Yu X

更新日期：2020-12-15 00:00:00

abstract：:Acetyltransferase was isolated by histone-Sepharose affinity chromatography from human cord blood red cells. The enzyme was detected only in very young red cells. The semipurified enzyme and [14C]acetyl-CoA were used to acetylate isolated Hb F tetramer and alpha and gamma subunits. The in vitro acetylated products wer...

journal_title：Life sciences

authors： Qiu CC,Kasten-Jolly J,Abraham EC

更新日期：1988-01-01 00:00:00

abstract：:1-oleoyl-2-acetyl glycerol (OAG), a potent activator of protein kinase C, inhibited the binding of 125I-labelled epidermal growth factor (EGF) in isolated rat pancreatic acini. Unlike cholecystokinin-octapeptide (CCK8) and the C-kinase activator 12-O-tetradecanoyl phorbol-13-acetate (TPA), two inhibitors of 125I-EGF e...

journal_title：Life sciences

authors： Brockenbrough JS,Korc M

更新日期：1987-04-20 00:00:00

abstract：:Identification of the neural substrates subserving audiogenic convulsions in the GEPR is an important task and while it is not yet complete, many laboratories employing various techniques have contributed importantly to our current understanding. The present review focuses on the use of lesions to identify the neural ...

journal_title：Life sciences

authors： Browning RA

更新日期：1986-09-08 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are integral membrane proteins that, in response to activation by extracellular stimuli, regulate intracellular second messenger levels via their coupling to heterotrimeric G proteins. GPCR activation also initiates a series of molecular events that leads to G protein-coupled recept...

journal_title：Life sciences

authors： Seachrist JL,Ferguson SS

更新日期：2003-12-05 00:00:00

abstract：:Male, 5 months old, massively obese, spontaneously hypertensive rats (Obese/SHR) were given 10 mg alloxan/100 g b.w., s.c., to induce diabetes. Control Obese and non-obese/SHR were given saline. Insulin therapy was withheld. All of the animals were killed at 6 months of age. Alloxan caused a slight but statistically s...

journal_title：Life sciences

authors： Wexler BC,Mc Murtry JP

更新日期：1983-09-12 00:00:00

abstract：:The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into the hippocampus. I...

journal_title：Life sciences

authors： Haruta K,Iguchi A,Matsubara T,Itoh K,Chen CL,Yoshida S,Terada R,Kanashiro M,Suzuki O,Nishimura H

更新日期：1992-01-01 00:00:00

abstract：:From the fruiting bodies of the edible mushroom Flammulina velutipes a single-chained ribosome inactivating protein with a molecular weight of 13.8 kDa was isolated with a procedure involving ion exchange chromatography on DEAE-cellulose and SP-Sepharose and affinity chromatography on Affi-gel blue gel. The protein wa...

journal_title：Life sciences

authors： Wang H,Ng TB

更新日期：2001-03-23 00:00:00

abstract：:The ontogeny and regulation by isoproterenol of type II thyroxine 5'-deiodinase, N-acetyltransferase, and hydroxyindole-O-methyltransferase activities were studied in the rat Harderian gland. Both 5'-deiodinase and N-acetyltransferase activities exhibited maximal values at the first week of age. These activities gradu...

journal_title：Life sciences

authors： Osuna C,Rubio A,Goberna R,Guerrero JM

更新日期：1990-01-01 00:00:00

abstract：:Previous experiments have shown that epinephrine-induced renin secretion in vivo apparently is initiated by activation of extrarenal adrenoceptors. However the location of these receptors has not been determined despite considerable search. The present experiments were designed to evaluate the hypothesis that epinephr...

journal_title：Life sciences

authors： Johnson MD

更新日期：1987-10-19 00:00:00

abstract：:The COVID-19 pandemic raised by SARS-CoV-2 is a public health emergency. However, lack of antiviral drugs and vaccine against human coronaviruses demands a concerted approach to challenge the SARS-CoV-2 infection. Under limited resource and urgency, combinatorial computational approaches to identify the potential inhi...

journal_title：Life sciences

authors： Bharadwaj S,Lee KE,Dwivedi VD,Kang SG

更新日期：2020-09-15 00:00:00

abstract：:There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of...

journal_title：Life sciences

authors： Jalil JE,Ebensperger R,Meléndez J,Acevedo E,Sapag-Hagar M,González-Jara F,Gálvez A,Pérez-Montes V,Lavandero S

更新日期：1999-01-01 00:00:00

abstract：:Activation of GABA(B) receptors produces analgesia in acute and chronic pain models. Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord. While much more potent GABA(B) receptor agonists (CGP 44532) have been ...

journal_title：Life sciences

authors： Enna SJ,Harstad EB,McCarson KE

更新日期：1998-01-01 00:00:00

abstract：:Lesions of the serotonergic afferents to the hippocampus, by fimbrial transection or by 5,7-dihydroxytryptamine treatment, produce an increase in the Bmax of [3H]WB4101 to its nanomolar affinity binding site, with no effect on its picomolar affinity binding site or on [3H]prazosin binding. The nanomolar site is seroto...

journal_title：Life sciences

authors： Morrow AL,Norman AB,Battaglia G,Loy R,Creese I

更新日期：1985-11-18 00:00:00

abstract：:To evaluate possible deleterious effects of commonly used herbicides on leukocytes, cytokine production was selected as a sensitive indicator. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleu...

journal_title：Life sciences

authors： Hooghe RJ,Devos S,Hooghe-Peters EL

更新日期：2000-05-19 00:00:00

abstract：AIMS:Previous investigations demonstrated that tramadol, as a painkiller, similar to morphine induces tolerance and dependence. Furthermore, the cannabinoid receptor 1 (CB1R) located in the nucleus accumbens (NAc) plays a critical role in morphine-induced conditioning. Therefore, the main objective of this study was to...

journal_title：Life sciences

authors： Sadeghi-Adl M,Sadat-Shirazi MS,Shahini F,Akbarabadi A,Khalifeh S,Borzabadi S,Nasehi M,Zarrindast MR

更新日期：2020-11-01 00:00:00

abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...

journal_title：Life sciences

authors： Kheirandish-Rostami M,Roudkenar MH,Jahanian-Najafabadi A,Tomita K,Kuwahara Y,Sato T,Roushandeh AM

更新日期：2020-03-01 00:00:00

abstract：AIMS:Transplantation of bone marrow mononuclear cells (BMMCs) exerts neuroprotection against cerebral ischemia. We examined the therapeutic timepoint of allogeneic BMMC transplantation in a rat model of focal cerebral ischemia, and determined the effects of repeated transplantation outside the therapeutic window. MAIN...

journal_title：Life sciences

authors： Kamiya F,Ueda M,Nito C,Kamiya N,Inaba T,Suda S,Saito T,Muraga K,Katayama Y

更新日期：2014-01-24 00:00:00