Abstract:
:1-oleoyl-2-acetyl glycerol (OAG), a potent activator of protein kinase C, inhibited the binding of 125I-labelled epidermal growth factor (EGF) in isolated rat pancreatic acini. Unlike cholecystokinin-octapeptide (CCK8) and the C-kinase activator 12-O-tetradecanoyl phorbol-13-acetate (TPA), two inhibitors of 125I-EGF endocytosis in the pancreas, OAG had no effect on the distribution of bound ligand between the cell surface and intracellular compartments. Unlike TPA, OAG failed to potentiate the inhibitory effects of the calcium ionophore A23187 on 125I-EGF cell-associated radioactivity and had no effect on either basal or carbachol-stimulated amylase release in acini. These data suggest that the actions of the synthetic diacyl-glycerol OAG are not fully equivalent with the action of other known activators of protein kinase C in the pancreatic acinar cell.
journal_name
Life Scijournal_title
Life sciencesauthors
Brockenbrough JS,Korc Mdoi
10.1016/0024-3205(87)90129-9subject
Has Abstractpub_date
1987-04-20 00:00:00pages
1625-31issue
16eissn
0024-3205issn
1879-0631pii
0024-3205(87)90129-9journal_volume
40pub_type
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