Endogenous digoxin-like immunoreactivity in blood is increased during prolonged strenuous exercise.

abstract：:Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diab...

journal_title：Life sciences

authors： Marya,Khan H,Nabavi SM,Habtemariam S

更新日期：2018-01-15 00:00:00

abstract：:Adenylate cyclase activity in pancreatic acinar cell membranes was determined in rats that had undergone a treatment with pentagastrin (250 micrograms/kg, intraperitoneal three times daily) for 1 week or that had undergone small bowel resection (90%) and were sacrified at 2 weeks, 1 month and 6 months after interventi...

journal_title：Life sciences

authors： Alvaro-Alonso I,Boyano-Adánez MC,Martín-Espinosa A,Arilla E

更新日期：1995-01-01 00:00:00

abstract：:Increased levels of particulate matter (PM) air pollutants in East Asia have resulted in detrimental health impacts increasing morbidity and mortality. Epidemiological studies suggest a possible relation between the cutaneous exposure of PM and increased oxidative stress and inflammation which lead to skin lesions. Th...

journal_title：Life sciences

authors： Fernando IPS,Jayawardena TU,Kim HS,Vaas APJP,De Silva HIC,Nanayakkara CM,Abeytunga DTU,Lee W,Ahn G,Lee DS,Yeo IK,Jeon YJ

更新日期：2019-09-15 00:00:00

abstract：:Histamine is a biogenic amine that plays an essential role in controlling many physiological functions, both in the central nervous system (CNS) and the peripheral nervous system (PNS). Most of these physiological effects are mediated through interactions with four histamine receptor subtypes, all of which are members...

journal_title：Life sciences

authors： Micallef S,Stark H,Sasse A

更新日期：2013-10-10 00:00:00

abstract：:The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 mon...

journal_title：Life sciences

authors： Liang YH,Wang JM,Zhou Y,Jiang XJ,Jiang H,Huang CX

更新日期：2004-08-27 00:00:00

abstract：:Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and suli...

journal_title：Life sciences

authors： Dairam A,Antunes EM,Saravanan KS,Daya S

更新日期：2006-11-10 00:00:00

abstract：:We investigated serum levels of type III procollagen aminopeptide (CIII), 7S type IV collagen (CIV), and tissue inhibitor of metalloproteinase (TIMP) in 33 patients with type II diabetes mellitus (DM) without uremia (serum creatinine less than 1.5 mg/dl). The patients were divided into three groups based on measuremen...

journal_title：Life sciences

authors： Ishimura E,Nishizawa Y,Shoji S,Mori H

更新日期：1996-01-01 00:00:00

abstract：AIMS:Clostridium difficile is an important pathogen in nosocomial infections. Although C. difficile toxins are considered to be major virulence factors, pathogenesis of C. difficile associated diseases remains to be determined. In this study, we investigated whether C. difficile flagellin is involved in the pathogenesi...

journal_title：Life sciences

authors： Yoshino Y,Kitazawa T,Ikeda M,Tatsuno K,Yanagimoto S,Okugawa S,Yotsuyanagi H,Ota Y

更新日期：2013-02-27 00:00:00

abstract：:The present study was performed to determine if the attenuated pressor response to vasopressin in conscious non-estrous female rats is due in part to an enhanced V2-like receptor vasodilator action. In male rats, infusion of vasopressin at a rate of 1 ng.min(-1).kg body weight-1 (wt) resulted in an increase in mean ar...

journal_title：Life sciences

authors： Wang YX,Crofton JT,Liu H,Sato K,Share L

更新日期：1996-01-01 00:00:00

abstract：AIMS:Ischemia-reperfusion (I/R) event in vascular and nervous system has been documented to rising ischemic and vasculitic neuropathic pain, clinically resembles the complex regional pain syndrome (CRPS). The present study evaluated the effect of montelukast, a cysteinyl leukotriene receptor (Cys-LTC(4) and Cys-LTD(4))...

journal_title：Life sciences

authors： Muthuraman A,Ramesh M,Sood S

更新日期：2012-05-22 00:00:00

abstract：:The systemic administration of neurotensin (NT) dose-dependently increased plasma adrenocorticotropin (ACTH) concentration in rats, and this effect was annulled by (alpha-helical)-CRH9-41, an antagonist of corticotropin-releasing hormone (CRH). The systemic administration of [D-Trp11]-neurotensin (NT-A), a specific NT...

journal_title：Life sciences

authors： Nussdorfer GG,Malendowicz LK,Meneghelli V,Mazzocchi G

更新日期：1992-01-01 00:00:00

abstract：:Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect ...

journal_title：Life sciences

authors： Oghbaei H,Rastgar Rezaei Y,Nikanfar S,Zarezadeh R,Sadegi M,Latifi Z,Nouri M,Fattahi A,Ahmadi Y,Bleisinger N

更新日期：2020-09-01 00:00:00

abstract：:The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...

journal_title：Life sciences

authors： Uchida S,Kato Y,Hirano K,Kagawa Y,Yamada S

更新日期：2007-04-03 00:00:00

abstract：:Arginine vasotocin has been proposed as a hormone of the mammalian pineal gland. This claim is largely based on biological and immunological results, although some chemical evidence has also been provided. Yet, more and more researchers have recently disclaimed the presence of this nonapeptide in mammalian tissue. The...

journal_title：Life sciences

authors： Nieuwenhuis JJ

更新日期：1984-10-22 00:00:00

abstract：:Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30 mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from 10 mg/kg of caffeine. The latter group was also tested for cr...

journal_title：Life sciences

authors： Holtzman SG

更新日期：1987-01-26 00:00:00

abstract：AIMS:We explored the effect of aerobic exercise on renal sinus adipose (RSA) accumulation and RSA accumulation-related renal injury in obese mice. MAIN METHODS:C57BL/6J male mice (n = 30) were evenly divided into three groups: control group (CON, n = 10), obese group (OB, n = 10; given high-fat diet) and obese + aerob...

journal_title：Life sciences

authors： Wang SS,Gu Q,Liu N,Li J,Liu X

更新日期：2021-01-23 00:00:00

abstract：:We report the presence of p-fluorophenylglycine (p-FPG) in the urine of six baboons treated with HPTP, the tetrahydropyridine dehydration product of haloperidol (HP). Oxidative N-dealkylation, the major metabolic pathway of HP, gives rise to 3-(4-fluorobenzoyl)propionic acid (p-FBPA). Subsequent beta-oxidation of p-FB...

journal_title：Life sciences

authors： Mienie LJ,Bergh JJ,Bloomquist JR,Castagnoli N Jr,Steyn SJ,Van der Schyf CJ

更新日期：1999-01-01 00:00:00

abstract：:More than 140 thousands of women suffer from endometrial carcinoma in the worldwide, and over 40 thousand of the patients die before and after in surgery and chemoradiotherapy because of its metastasis. However, its molecular mechanism is much less known compared to other cancers. In this study, we demonstrated that l...

journal_title：Life sciences

authors： Zhang C,Shao S,Zhang Y,Wang L,Liu J,Fang F,Li P,Wang B

更新日期：2020-02-15 00:00:00

abstract：:Vanilloid spice principles, including capsaicin, stimulate vasoconstriction in the rat hindlimb perfused at constant flow and, depending on dose, either stimulate or inhibit oxygen consumption by this vascular bed. We now present metabolic and functional evidence for two different vanilloid (VN1 and VN2) receptor type...

journal_title：Life sciences

authors： Colquhoun EQ,Eldershaw TP,Bennett KL,Hall JL,Dora KA,Clark MG

更新日期：1995-01-01 00:00:00

abstract：:The changes in hepatic energy state were assessed by 31P-nuclear magnetic resonance spectroscopy (31P-MRS) and arterial ketone body ratio (AKBR) in brain dead dogs. 31P-MRS and AKBR were measured before and at 3 hours after brain death. Wiggers' shock model was employed to compare the energy metabolism during hypotens...

journal_title：Life sciences

authors： Kitai T,Tanaka A,Terasaki M,Okamoto R,Ozawa K,Morikawa S,Inubushi T

更新日期：1991-01-01 00:00:00

abstract：:The kinetic parameters of serotonin (5-HT) uptake and imipramine binding of the synaptosomes and blood platelets of male Fawn-hooded rats, which have a 5-HT storage abnormality, and normal Sprague-Dawley rats were compared. The Vmax for 5-HT uptake of synaptosomes from Fawn-hooded rats was significantly greater than t...

journal_title：Life sciences

authors： Arora RC,Tong C,Jackman HL,Stoff D,Meltzer HY

更新日期：1983-08-01 00:00:00

abstract：:We produced thiamine-deficient (TD) mice by TD diet treatment. The growth curve of mice on TD feeding was sharply increased until on the 10th day and subsequently the body weight gradually decreased. The mortality rate in mice was about 67% on the 30th day after the start of TD feeding. We performed the forced swimmin...

journal_title：Life sciences

authors： Nakagawasai O,Tadano T,Hozumi S,Taniguchi R,Tan-No K,Esashi A,Niijima F,Kisara K

更新日期：2001-07-27 00:00:00

abstract：:The effect of several anti-inflammatory drugs (NSAIDs), the calmodulin inhibitor W-7 and cortisol on vanadate-induced tonic contraction and on calmodulin dependent cAMP-phosphodiesterase activity have been assayed. Indomethacin, diclofenac, phenylbutazone, mefenamic acid, naproxen, tolmetin, piroxicam, aspirin and W-7...

journal_title：Life sciences

authors： Cantabrana B,Perez Vallina JR,Menéndez L,Hidalgo A

更新日期：1995-01-01 00:00:00

abstract：AIMS:Reactive oxygen species (ROS) are generated in the ischaemic myocardium especially during early reperfusion and affect myocardial function and viability. Monoterpenes have been proposed to play beneficial roles in diverse physiological systems; however, the mechanisms of action remain largely unknown. This study a...

journal_title：Life sciences

authors： Crespo R,Wei K,Rodenak-Kladniew B,Mercola M,Ruiz-Lozano P,Hurtado C

更新日期：2017-03-01 00:00:00

abstract：:In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the b...

journal_title：Life sciences

authors： Theobald RJ Jr,Hoffman V

更新日期：1986-04-28 00:00:00

abstract：:The in vitro and in vivo regulation of [3H]Ro 5-4864 binding to peripheral benzodiazepine receptors (PBR) by ion transport/exchange inhibitors was studied in the kidney. The potencies of 9-anthroic acid, furosemide, bumetanide, hydrochlorothiazide and SITS as inhibitors of [3H]Ro 5-4864 binding to renal membranes were...

journal_title：Life sciences

authors： Basile AS,Lueddens HW,Skolnick P

更新日期：1988-01-01 00:00:00

abstract：:Nucleotides, e.g. ATP and ADP, are important signaling molecules, which elicit several biological responses. The degradation of nucleotides is catalyzed by a family of enzymes called NTPDases (nucleoside triphosphate diphosphohydrolases). The present study reports the enzymatic properties of a NTPDase (CD39, apyrase, ...

journal_title：Life sciences

authors： Rico EP,Senger MR,Fauth Mda G,Dias RD,Bogo MR,Bonan CD

更新日期：2003-09-05 00:00:00

abstract：:The effects of nineteen AHPA* derivatives were examined on morphine analgesia by tail-flick test in rats and on enkephalinase inhibition which was based on the formation of tyrosyl-glycyl-glycine from met-enkephalin. The correlation between the enhancement of morphine analgesia in vivo and enkephalinase inhibition in ...

journal_title：Life sciences

authors： Hachisu M,Nakamura T,Kawashima H,Shitoh K,Fukatsu S,Koeda T,Sekizawa Y,Munakata M,Kawamura K,Umezawa H,Takeuchi T,Aoyagi T

更新日期：1982-05-17 00:00:00

abstract：:Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...

journal_title：Life sciences

authors： Bhalla S,Andurkar SV,Gulati A

更新日期：2016-08-15 00:00:00

abstract：:Long non-coding RNA (LncRNA) involved in types of physiological insults and diseases via regulating the responses of complex molecular, including cerebral ischemia-reperfusion (I/R) injury. LncRNA SNHG16 played a potential role in ketamine-induced neurotoxicity. In this study, we utilized an in vitro cell model of I/R...

journal_title：Life sciences

authors： Pan H,Zhao F,Yang Y,Chang N

更新日期：2020-08-01 00:00:00