Abstract：
:Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diabetes including insulin for type I and oral tablets for type II, but its effective management is still a dream. To date, several options are under investigation in various research laboratories for efficacious and safer agents. Of them, peptides are currently amongst the most widely investigated potential therapeutic agents whose design and optimal uses are under development. A number of natural and synthetic peptides have so far been found with outstanding antidiabetic effect mediated through diverse mechanisms. The applications of new emerging techniques and drug delivery systems further offer opportunities to achieve the desired target outcomes. Some outstanding peptides in preclinical and clinical studies with better efficacy and safety profile have already been identified. Further detail studies on these peptides may therefore lead to significant clinically useful antidiabetic agents.
journal_name
Life Scijournal_title
Life sciencesauthors
Marya,Khan H,Nabavi SM,Habtemariam Sdoi
10.1016/j.lfs.2017.10.025subject
Has Abstractpub_date
2018-01-15 00:00:00pages
153-158eissn
0024-3205issn
1879-0631pii
S0024-3205(17)30539-8journal_volume
193pub_type
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