Abstract：
:Electrically evoked release of dopamine from the caudate nucleus is reduced by the dopamine receptor agonists, apomorphine and bromocriptine, and facilitated by neuroleptic drugs, which act as dopamine autoreceptor antagonists. The potencies of chlorpromazine, fluphenazine, levomepromazine and their hydroxy-metabolites in modulating electrically evoked release of dopamine were examined by superfusion of rabbit caudate nucleus slices pre-incubated with 3H-dopamine. O-Desmethyl levomepromazine, 3-hydroxy- and 7-hydroxy metabolites of chlorpromazine and levomepromazine facilitated electrically evoked release of 3H-dopamine, having potencies similar to that of the parent compounds. 7-Hydroxy fluphenazine was less active than fluphenazine in this system. These results indicate that phenolic metabolites of chlorpromazine and levomepromazine, but not of fluphenazine, may contribute to effects of the drugs mediated by presynaptic dopamine receptors.
journal_name
Life Scijournal_title
Life sciencesauthors
Nowak JZ,Arbilla S,Dahl SG,Langer SZdoi
10.1016/0024-3205(90)90088-9subject
Has Abstractpub_date
1990-01-01 00:00:00pages
443-51issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(90)90088-9journal_volume
46pub_type
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