Abstract：
:Administration of cyclosporine (CS) as an immunosuppressive agent in clinical transplantation is associated with multiple side effects including nephrotoxicity and hypertension. These two effects could be related in that the renal changes may be secondary to alterations in organ blood flow. The present studies investigate the ability of CS to augment contractile responsiveness in blood vessels from normotensive rats. Isometric force generation was measured in isolated tail arteries and portal veins. CS (8.3 X 10(-6)M) potentiated tail artery contractile responses to sympathetic nerve stimulation, exogenous norepinephrine, and increases in extracellular potassium concentration. Portal veins undergo spontaneous contractions which are related to the firing of calcium-driven action potentials in the smooth muscle cells. CS significantly increased the frequency of these spontaneous contractile events. These results suggest that components of CS toxicity may involve a direct action on vascular smooth muscle and/or on vascular adrenergic neurotransmission.
journal_name
Life Scijournal_title
Life sciencesauthors
Lamb FS,Webb RCdoi
10.1016/0024-3205(87)90080-4subject
Has Abstractpub_date
1987-06-29 00:00:00pages
2571-8issue
26eissn
0024-3205issn
1879-0631pii
0024-3205(87)90080-4journal_volume
40pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Increased oxidative stress plays a role in the pathogenesis of beta-cell dysfunction and death. We studied isoforms of NADPH oxidase components in islets of Langerhans isolated from rat pancreas and tumoral rat beta-cell line RINm5F cells by RT-PCR and sequencing of its products. RT-PCR revealed that isolated islets c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.08.031
更新日期：2006-12-14 00:00:00
abstract：BACKGROUND:Cisplatin resistance has been found to contribute to the failure of ovarian carcinoma treatment. Oridonin is a natural en-kaurane tetracyclic diterpenoid compound discovered in Rabdosia rubescene (Henmsl.) Hara. Herein, we tested whether oridonin could exert chemo-sensitization activity on cisplatin-resistan...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116709
更新日期：2019-09-15 00:00:00
abstract：:We have demonstrated that both high-K+ and electrical stimulation of the vagus nerves release endogenous glutamate from the vascularly-perfused rat stomach in a calcium-dependent manner. In the present study, we examined properties of calcium channel subtypes mediating endogenous glutamate release from the stomach. Ap...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00121-0
更新日期：1998-01-01 00:00:00
abstract：:T cell receptor (TCR/CD3) induced fluctuations in intracellular free ionizied calcium, [Ca2+]i, was analysed in the human T leukemia cell clone, Jurkat, cultured in the presence of the opioid methionine enkephalinamide (Met-Enk) in titrated concentrations (10[-7] to 10[-15] M) or saline (PBS). In the majority of indiv...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00055-1
更新日期：1998-01-01 00:00:00
abstract：:The aim of this work was to evaluate the effect of the antioxidant stobadine on ischemia/reperfusion-induced injury of the isolated rat heart. Experiments were performed according to Langendorff. Ischemia was induced by stop-flow lasting 30 minutes and the duration of repefusion was 30 minutes. Reperfusion of the isch...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00450-6
更新日期：1999-01-01 00:00:00
abstract：:Using a laterality questionnaire, 138 normal healthy individuals were classified as right-sided and 25 as non-right sided. Interleukin-2 (IL-2) was generated from whole blood obtained from these subjects using mitogen (PHA) stimulation. IL-2 was quantitated in picograms/ml using an enzyme immunoassay (ELISA). Addition...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90035-n
更新日期：1992-01-01 00:00:00
abstract：AIMS:Overproduction of nitric oxide (NO) from inducible NO synthase (iNOS) plays many pivotal roles in various inflammatory diseases. In this study, we examined the effects of 6 flavonoids on lipopolysaccharide (LPS)-induced NO generation in macrophage (Mφ), and addressed molecular mechanisms of cardamonin. MAIN METHO...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.06.027
更新日期：2011-08-29 00:00:00
abstract：:We studied Na,K-ATPase mRNA expression in cardiomyopathic (Bio 14.6) and normal (F1b) Syrian hamster ventricles. In Northern blot analysis, Na,K-ATPase alpha 1, alpha 2, alpha 3 and beta 1 isoform mRNAs were detected in 3-week-old Bio 14.6 and F1b hamster ventricles. We then investigated the expression of alpha 1 subu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00776-4
更新日期：1994-01-01 00:00:00
abstract：AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.05.008
更新日期：2018-07-15 00:00:00
abstract：AIMS:To determine whether increased N-acetyltransferase (NAT) activity might have a toxic effect during development and an influence on folate levels since previous work has shown that only low levels of exogenous NAT can be achieved in constitutionally transgenic mice (Cao et al. 2005). MAIN METHODS:A human NAT1 tet-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.11.008
更新日期：2010-01-16 00:00:00
abstract：AIMS:Opioid addiction is associated with long-term adaptive changes in the brain that involve protein expression. The carboxyl-terminal of the μ opioid receptor (MOR-C) is important for receptor signal transduction under opioid treatment. However, the proteins that interact with MOR-C after chronic morphine exposure re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.10.032
更新日期：2015-12-15 00:00:00
abstract：:Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diab...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2017.10.025
更新日期：2018-01-15 00:00:00
abstract：:This study compared the structure-activity relationships of 16 analogues at the A1 and A2 adenosine receptors (A1AR, A2AR) of rat and guinea pig. Radioligand binding studies revealed no marked differences in the affinities of each analogue at the A1AR of brain cortex or the A2AR of brain striatum. Bioassay employing L...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90199-l
更新日期：1991-01-01 00:00:00
abstract：AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.064
更新日期：2016-04-15 00:00:00
abstract：:Further confirmation that the LHRH/LHRH agonist-induced ovulation in the hypophysectomized (hypx) rat is due to a direct ovarian effect and not mediated by LH release from residual pituitary tissue or other CNS sites is provided by the persistence of this effect despite concomitant median eminence lesion or passive im...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90663-5
更新日期：1984-08-27 00:00:00
abstract：AIMS:Rg1 is the most active component of traditional Chinese medicine ginseng, having anti-aging and anti-oxidative stress features in multiple organs. Cellular senescence of hepatocytes is involved in the progression of a wide spectrum of chronic liver diseases. In this study, we investigated the potential benefits an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117776
更新日期：2020-08-01 00:00:00
abstract：AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible u...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.11.018
更新日期：2016-01-01 00:00:00
abstract：:Juncusol, phenolic compound, was isolated from the black needlerush, Juncus roemerianus. Different concentrations of this extract were tested for toxicity against selected species of estuarine fish and grass shrimp. Juncusol was ten times more toxic to the various species of fish than to grass shrimp. At 2.0 ppm conce...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90317-4
更新日期：1982-05-24 00:00:00
abstract：:Anandamide (arachidonylethanolamide; AEA) is an endogenous ligand for the cannabinoid receptor and its pharmacological effects are under intensive study. However, AEA has a low aqueous solubility and stability which may restrict its use and may eventually endanger the reliability of the obtained results. In the presen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00024-0
更新日期：1996-01-01 00:00:00
abstract：:Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion. Ki...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90436-u
更新日期：1990-01-01 00:00:00
abstract：:Alpha-inhibin-92 (alpha-IB-92) has been characterized from human seminal plasma and found to be active in suppressing FSH release in vitro and in vivo. In order to determine if smaller fragments of this 92 amino acid peptide would still be active to suppress FSH release, we have evaluated 5 of these fragments for thei...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90100-7
更新日期：1994-01-01 00:00:00
abstract：:The effects of adenosine on the amylase secretion from rat pancreatic lobules have been studied. Adenosine induces a dose-dependent stimulation on amylase release, which is maximal at a concentration of 10(-4) M. It has been observed a clear inhibition of this secretory action when atropine was added whereas no amylas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02140-e
更新日期：1995-01-01 00:00:00
abstract：:To clarify the mechanism by which Delta9-tetrahydrocannabinol, a major psychoactive component of marijuana, impairs spatial memory in the 8-arm radial maze in rats via the cholinergic system, we used two acetylcholinesterase inhibitors, physostigmine and tetrahydroaminoacridine. Moreover, we examined the effect of Del...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02274-9
更新日期：2002-12-20 00:00:00
abstract：OBJECTIVE:This study investigated the role of long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in kidney injury induced by urine-derived sepsis (US). MATERIALS AND METHODS:An Escherichia coli suspension was injected into the distal ureter of adult male Sprague Dawley rats to establish a US model. Lipo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.041
更新日期：2018-10-01 00:00:00
abstract：:The role of dopamine (DA) input on the activity of glutamate neurons was investigated on rat striatal and cortical tissue using the measurement of sodium-dependent high affinity glutamate uptake (HAGU) as an index. Incubation of the tissue in the presence of DA, apomorphine or bromocriptine produced marked inhibition ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90658-0
更新日期：1982-04-05 00:00:00
abstract：AIMS:To evaluate potential agents of therapeutic value in tissue inflammation, we studied norcantharidin (NCTD) and its derivatives for their effects on immune responses of human peripheral blood mononuclear cells (PBMC) in vitro. MAIN METHODS:PBMC proliferation was evaluated by tritiated thymidine uptake method. The ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.11.020
更新日期：2009-02-13 00:00:00
abstract：:The effects of sucrose feeding on parameters associated with (Na+,K+)-ATPase in brown adipose tissue were compared in rats treated with parenteral 6-hydroxydopamine and vehicle. Sucrose feeding significantly increased K+-p-nitrophenylphosphatase and ouabain binding in brown adipose tissue from rats treated with vehicl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90623-4
更新日期：1984-01-23 00:00:00
abstract：:To analyze the metabolisms of platelet-activating factor (PAF) and Thromboxane A2 (TxA2) when platelets and mesangial cells (MC) interact, immunoreactive thromboxane B2 (TxB2) and PAF were measured after incubation of cultured rat MC with platelets (P) and with platelet supernatants (PS). In both cases, TxB2 significa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02030-m
更新日期：1995-01-01 00:00:00
abstract：:A radioreceptor assay using [3H]nitrendipine and rat cerebral cortical membranes, in conjunction with equilibrium dialysis, measures the unbound (free) level of nitrendipine in human sera. The sensitivity of the assay is 0.1-0.2 picomoles/ml and is linear from 4 X 10(-11) to 4 X 10(-9) M nitrendipine. Other dihydropyr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90690-2
更新日期：1983-10-31 00:00:00
abstract：:It has been previously shown that treatment of newborn rats with the polyamines putrescine, spermidine and spermine can rescue sympathetic neurons from naturally occurring cell death and from induced death after axotomy or immunosympathectomy. The present study demonstrates that polyamine treatment can also prevent th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90409-8
更新日期：1989-01-01 00:00:00
