Cardiovascular actions of adenosines, but not adenosine receptors, differ in rat and guinea pig.

abstract：:Viperid, elapid and crotalid snake venoms were screened in vitro for antiviral activity against Sendai virus. The hemolysis of 10(8) human erythrocytes in 1 ml, caused by 70 HAU of Sendai virus, was abolished when the virions were pretreated with 10 ug of the viperid venom of Echis coloratus, and was considerably dimi...

journal_title：Life sciences

authors： Borkow G,Ovadia M

更新日期：1992-01-01 00:00:00

abstract：:It is generally assumed that enkephalinase A, a highly thiorphan-sensitive dipeptidylcarboxypeptidase cleaving the Gly-Phe bond during enkephalin degradation, is bound to the neuronal membrane. To clarify the localization of the enzyme, we used three neuron-like models (neuroblastoma cells N1E-115, bulk prepared neuro...

journal_title：Life sciences

authors： Lentzen H,Monden I,Linke J,Palenker J

更新日期：1983-01-01 00:00:00

abstract：:Insulin binding and 3-0-Methylglucose transport have been studied in erythrocyte- and reticulocyte-enriched fractions of blood cells in order to determine if the increased number of insulin binding sites in reticulocytes is associated with a glucose transport response to insulin. In these experiments rabbit reticulocy...

journal_title：Life sciences

authors： Albert SG

更新日期：1982-07-19 00:00:00

abstract：AIMS:Cortisol is a glucocorticoid in mammals, but has both gluco- and mineralocorticoid activities in teleost fish. Our previous in vivo studies on osmoregulatory esophagi of euryhaline fish showed that epithelial apoptosis for the simple epithelium in seawater and cell proliferation for the stratified epithelium in fr...

journal_title：Life sciences

authors： Takagi C,Takahashi H,Kudose H,Kato K,Sakamoto T

更新日期：2011-01-31 00:00:00

abstract：:The pineal gland hormone melatonin is now considered an important neuroendocrine component of animal physiology. Although the functional status of melatonin has been well described for subhuman species, there is a paucity of data concerning the physiological role of this hormone in man. This paucity of data has much t...

journal_title：Life sciences

authors： Miles A

更新日期：1989-01-01 00:00:00

abstract：:Site-directed mutagenesis has been used to evaluate the roles of the key aspartate and arginine residues in transmembrane domain three of the muscarinic receptors. The results suggest that the formation of an ionic bond between the Asp carboxylate group and the onium headgroup is essential to anchor acetylcholine in i...

journal_title：Life sciences

authors： Hulme EC,Curtis CA,Page KM,Jones PG

更新日期：1995-01-01 00:00:00

abstract：:A simple, selective reverse-phase HPLC-fluorometric method is described for the determination of serotonin (5HT) in cisternal CSF of the rat. The mean (+/- SE) value of CSF 5HT observed in control adult rats was 457 +/- 83 pg/ml (N = 16). In an attempt to validate the measure as an index of extracellular, or functiona...

journal_title：Life sciences

authors： Anderson GM,Teff KL,Young SN

更新日期：1987-06-08 00:00:00

abstract：:Cyclic octapeptide analogues of somatostatin (SS) like SMS 201-995 [H-(D) Phe-Cys-Phe-(D) Trp-Lys-Thr-Cys-Thr(ol)] or its Tyr3-derivative 204-090, displaced [125I-Tyr11]-SS 100% from pancreatic membranes but only 62-75% from brain membranes; the remaining sites were displaced by SS. These data indicate that some mini-...

journal_title：Life sciences

authors： Reubi JC

更新日期：1985-05-13 00:00:00

abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...

journal_title：Life sciences

authors： Kheirandish-Rostami M,Roudkenar MH,Jahanian-Najafabadi A,Tomita K,Kuwahara Y,Sato T,Roushandeh AM

更新日期：2020-03-01 00:00:00

abstract：:This study was designed to document possible changes in bupivacaine and its main metabolite, des-butyl-bupivacaine (PPX) kinetics in mice after a single 5 mg/kg injection of diltiazem. After a single 20 mg/kg i.p. dose of bupivacaine, kinetic parameters of bupivacaine were not statistically different but the ratio AUC...

journal_title：Life sciences

authors： Bruguerolle B,Lorec AM

更新日期：1994-01-01 00:00:00

abstract：:Botanical sources for medicines in America have been known since long before the arrival of Columbus. Nevertheless, both scientists and the general public are often unaware that some of these botanical drugs are also potent intoxicants. We provide a quick overview of hallucinogenic and dissociative drugs harvested fro...

journal_title：Life sciences

authors： Halpern JH,Sewell RA

更新日期：2005-12-22 00:00:00

abstract：:The effects of nineteen AHPA* derivatives were examined on morphine analgesia by tail-flick test in rats and on enkephalinase inhibition which was based on the formation of tyrosyl-glycyl-glycine from met-enkephalin. The correlation between the enhancement of morphine analgesia in vivo and enkephalinase inhibition in ...

journal_title：Life sciences

authors： Hachisu M,Nakamura T,Kawashima H,Shitoh K,Fukatsu S,Koeda T,Sekizawa Y,Munakata M,Kawamura K,Umezawa H,Takeuchi T,Aoyagi T

更新日期：1982-05-17 00:00:00

abstract：:Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how auto...

journal_title：Life sciences

authors： Raj S,Chandel V,Kumar A,Kesari KK,Asthana S,Ruokolainen J,Kamal MA,Kumar D

更新日期：2020-10-15 00:00:00

abstract：:We evaluated the effect of several classes of calmodulin inhibitors on the activity of calmodulin prepared from C6 astrocytoma cells and studied the activity of these drugs as inhibitors of the growth of C6 cells in tissue culture. There was a good correlation between the activity of the drugs as inhibitors of calmodu...

journal_title：Life sciences

authors： Lee GL,Hait WN

更新日期：1985-01-28 00:00:00

abstract：:Alteration in microbial populations and metabolism are key events associated with disruption of intestinal homeostasis and immune tolerance during intestinal inflammation. A substantial imbalance in bacterial populations in the intestine and their relationships with the host have been observed in patients with inflamm...

journal_title：Life sciences

authors： Figliuolo VR,Coutinho-Silva R,Coutinho CMLM

更新日期：2018-12-15 00:00:00

abstract：:Subcutaneous administration of naloxone at 1 to 10 mg/kg produced a dose-related decrease in feed intake of broiler chicks. Food deprivation for 3, 6, 12, and 24 hours produced a significant increase in feed intake compared to non-food deprived birds. Subcutaneous administration of naloxone at 1 to 10 mg/kg failed to ...

journal_title：Life sciences

authors： Sangiah S,Alavi FK,Teeter RG,Amouzadeh HR,Mauromoustakos A

更新日期：1988-01-01 00:00:00

abstract：:In this study, we investigated the effects of zinc L-carnosine, an anti-ulcer drug, on acetic acid-induced colonic mucosal injury and the correlation of these effects with expression of 72-kDa heat shock proteins (HSP72) and nuclear factor kappa B (NF-kappaB) activation in rat colonic mucosa in vivo. After intrarectal...

journal_title：Life sciences

authors： Odashima M,Otaka M,Jin M,Wada I,Horikawa Y,Matsuhashi T,Ohba R,Hatakeyama N,Oyake J,Watanabe S

更新日期：2006-11-10 00:00:00

abstract：:In the present study, we elucidated the possible role of hemodynamic parameters and chemical factors in the development of ventricular hypertrophy (VH) following chronic nitric oxide (NO) deprivation with Nomega-nitro-L-arginine methyl ester (L-NAME). Impedance spectral analysis was used to obtain the arterial hemodyn...

journal_title：Life sciences

authors： Hu CT,Chang HR,Hsu YH,Liu CJ,Chen HI

更新日期：2005-11-26 00:00:00

abstract：AIMS:Individual susceptibility to develop obesity may impact the development of cardio-metabolic risk factors that lead to obesity-related comorbid conditions. Obesity-prone Osborne-Mendel (OM) rats expressed higher levels of visceral adipose inflammation than obesity-resistant, S5B/Pl (S5B) rats. However, the consumpt...

journal_title：Life sciences

authors： Poret JM,Battle C,Mouton AJ,Gaudet DA,Souza-Smith F,Gardner JD,Braymer HD,Harrison-Bernard L,Primeaux SD

更新日期：2019-04-15 00:00:00

abstract：:Toll-like receptors (TLRs) play important roles in the pathogenesis of atherosclerosis. On the other hand, serum high sensitivity C-reactive protein (hsCRP) is known as an independent coronary risk factor, but cardiovascular events do occur even in low hsCRP levels. We investigated whether the TLR4 expression levels o...

journal_title：Life sciences

authors： Shiraki R,Inoue N,Kobayashi S,Ejiri J,Otsui K,Honjo T,Takahashi M,Hirata K,Yokoyama M,Kawashima S

更新日期：2006-12-03 00:00:00

abstract：:An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...

journal_title：Life sciences

authors： Gambacciani M,Yen SS,Rasmussen DD

更新日期：1988-01-01 00:00:00

abstract：AIM:This study investigated the effect of voluntary motor effort during a low-intensity (30% maximal voluntary contraction [MVC]) muscle exercise training program on increasing muscle strength. MATERIALS AND METHODS:Eighteen young and healthy individuals were randomly assigned to one of three groups: high mental effor...

journal_title：Life sciences

authors： Jiang CH,Ranganathan VK,Siemionow V,Yue GH

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION AND AIM:Polycystic ovary syndrome is one of the most common causes of female infertility, affecting 5-10% of the population. Women with PCOS manifest hyperandrogenism, hyperinsulinemia, low-grade systemic inflammation, and polycystic ovaries. Unfortunately, current available medications are only symptomati...

journal_title：Life sciences

authors： Khaled N,El-Bahy AA,Radwan R,Handoussa H,AbdelMaksoud S

更新日期：2019-09-01 00:00:00

abstract：AIM:Muscle atrophy is a common symptom after nerve denervation. Myostatin propeptide, a precursor of myostatin, has been documented to improve muscle growth. However, the mechanism underlying the muscle atrophy attenuation effects of myostatin propeptide in muscles and the changes in gene expression are not well establ...

journal_title：Life sciences

authors： Tsai SW,Tung YT,Chen HL,Yang SH,Liu CY,Lu M,Pai HJ,Lin CC,Chen CM

更新日期：2016-02-01 00:00:00

abstract：:The temperature effects of naloxone and naltrexone (1-30 mg/kg) were examined in well habituated male rats. These drugs had a similar time course and potency, producing a dose-dependent hypothermia followed several hours later by a hyperthermia. A subsequent study found that not only did 30 mg/kg of naloxone or naltre...

journal_title：Life sciences

authors： Eikelboom R

更新日期：1987-03-16 00:00:00

abstract：:Substrate stiffness is essential for cell functions, but the mechanisms by which cell sense mechanical cues are still unclear. Here we show that the frequency and the amplitude of spontaneous Ca2+ oscillations were greater in chick cardiomyocytes cultured on the stiff substrates than that on the soft substrates. The s...

journal_title：Life sciences

authors： Liu S,Gao X,Wu X,Yu Y,Yu Z,Zhao S,Zhao H

更新日期：2019-10-15 00:00:00

abstract：AIMS:Chemo-resistance still was the main obstacle for AML patients, more effective and less toxic forms of therapies were desperately needed. Metformin, a classic hypoglycemic drug for diabetes recently delivered us a new identity that it exerted anti-tumor activity through suppressing mTOR in various tumors. But the a...

journal_title：Life sciences

authors： Yuan F,Cheng C,Xiao F,Liu H,Cao S,Zhou G

更新日期：2020-02-15 00:00:00

abstract：:Isolated myocytes for biochemical experiments must be homogeneous and highly enriched in viable cells. For cardiac myocytes, isolation of Ca2+-tolerant cells in high yield and with good viability has been possible from rat. This paper describes myocyte isolation and enrichment procedures which are effective for severa...

journal_title：Life sciences

authors： Stemmer P,Akera T,Brody TM,Rardon DP,Watanabe AM

更新日期：1989-01-01 00:00:00

abstract：:Responses to synthetic human adrenomedullin, a novel hypotensive peptide localized in several organ systems, including the lung, and the carboxy terminal 15-52 amino acid fragment of adrenomedullin (ADM15-52) were investigated in the pulmonary vascular bed of the intact-chest cat. Under constant flow conditions when b...

journal_title：Life sciences

authors： Cheng DY,DeWitt BJ,Wegmann MJ,Coy DH,Bitar K,Murphy WA,Kadowitz PJ

更新日期：1994-01-01 00:00:00

abstract：:Pretreatment with a low dose of 3-nitropropionic acid (3-NPA) has been shown to induce ischemic tolerance in the gerbil hippocampus. It is well known that sublethal (2-min) ischemia also induces ischemic tolerance. To investigate the acquisition of ischemic tolerance with 3-NPA, we examined the protein expression afte...

journal_title：Life sciences

authors： Kato K,Shimazaki K,Kamiya T,Amemiya S,Inaba T,Oguro K,Katayama Y

更新日期：2005-10-21 00:00:00