Abstract:
:Alpha-inhibin-92 (alpha-IB-92) has been characterized from human seminal plasma and found to be active in suppressing FSH release in vitro and in vivo. In order to determine if smaller fragments of this 92 amino acid peptide would still be active to suppress FSH release, we have evaluated 5 of these fragments for their effects on FSH and LH release in the present study. Five alpha-IB-92 fragments (1-34, 1-46, 35-65, 35-92 and 66-92) were synthesized and injected intravenously (iv) into castrated adult rats (2 days post operation). Only fragments alpha-IB-92-(35-65) and alpha-IB-92-(66-92) significantly lowered plasma FSH, but not LH, at doses of 10 micrograms. These fragments exerted a preferential FSH-suppressing effect, but their activities were less than that of alpha-IB-92. In view of the rapid action of these peptides and the preferential FSH suppressing effect, they could be useful clinically to suppress FSH release. To determine the possible physiologic significance of alpha-IB-92, we injected antiserum raised against alpha-IB-92 into immature male rats and evaluated its effects on FSH and LH release. Normal rabbit serum (NRS) or anti-alpha-IB-92 serum was injected iv through indwelling jugular catheters into conscious, unrestrained 18 day-old male rats. Blood samples (0.2 ml) were collected at various intervals. Intravenous injection of alpha-IB-92 antiserum (0.1 ml/rat) selectively elevated plasma levels of FSH but not LH from 2-8 h post-injection in 18 day-old male rats (P < 0.01). Since immunoneutralization of alpha-IB-92 significantly elevated FSH release in immature rats, alpha-IB-92 has a physiological inhibiting role in control of FSH but not LH release at this stage of development.
journal_name
Life Scijournal_title
Life sciencesauthors
Yu WH,Riedel M,Yamashiro D,Ramasharma K,McCann SMdoi
10.1016/0024-3205(94)90100-7subject
Has Abstractpub_date
1994-01-01 00:00:00pages
93-102issue
2eissn
0024-3205issn
1879-0631pii
0024-3205(94)90100-7journal_volume
55pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117994
更新日期:2020-09-15 00:00:00
abstract::The Sertoli cells play an essential role in the maintenance and control of spermatogenesis. The ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) and 5'-nucleotidase activities can modulate the extracellular adenine nucleotide levels, controlling nucleotide-mediated signaling events in Sertoli cells. Since t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.08.020
更新日期:2006-12-03 00:00:00
abstract:AIMS:Hypertension is one of the leading causes of cardiovascular mortality and morbidity. It is associated with severe cardiac and vascular dysfunction. Double-stranded RNA-dependent protein kinase (PKR), is a known inducer of inflammation and apoptosis. However, no research has been done to elucidate the role of the P...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118436
更新日期:2020-12-01 00:00:00
abstract::The use of more than one drug to achieve a desired effect has been a common practice in pharmacologic testing and in clinical practice. For example, combinations of analgesics are frequently prescribed with a view to enhancing pain relief and reducing adverse effects. It is also well established that administration of...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(89)90148-3
更新日期:1989-01-01 00:00:00
abstract::Plasma and urinary levels of MHPG were determined in six normal volunteers. Samples were obtained at 3-hour intervals for plasma and at 12-hour intervals for urine. Acrophase, amplitude and period were determined for plasma MHPG levels. A sinusoidal pattern was obtained for diurnal plasma MHPG with a peak at 15:00 hrs...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90302-9
更新日期:1985-11-04 00:00:00
abstract:AIM:MicroRNAs (miRNAs) function as oncogenes or tumor suppressors in an extensive variety of human cancers, including prostate cancer (PCa). Herein, the aim of this study is to investigate the effect of miR-381 on autophagy and apoptosis of PCa cells through the reelin (RELN)-mediated the PI3K/AKT/mTOR signaling pathwa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117672
更新日期:2020-08-01 00:00:00
abstract::The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00495-e
更新日期:1995-01-01 00:00:00
abstract::We examined, in young adult women, the association between current low dose oral contraceptive (OC) use and plasma levels of C-reactive protein (CRP), an acute phase reactant predictive of cardiovascular disease risk. We conducted a cross-sectional analysis of 30 healthy, non-smoking, non-obese women (18 OC users and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00425-9
更新日期:2003-07-25 00:00:00
abstract::The purpose of this present study was to develop a method for stimulation of acid secretion by the isolated perfused rat stomach. Rat stomachs were perfused in situ via the abdominal aorta and celiac axis with Krebs-Ringer bicarbonate buffer in the presence or absence of 10% ovine erythrocytes. The gastric lumen was p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90289-3
更新日期:1984-06-18 00:00:00
abstract:AIMS:Antenatal glucocorticoid therapy has been shown to prevent acute diseases including infant respiratory distress syndrome and reduce mortality, although little is known about the effects on cardiac function-related proteins in the fetus or neonate. We investigated whether cardiac function-related proteins were alte...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.06.017
更新日期:2009-10-21 00:00:00
abstract::The role of Na+ and Ca2+ channels in glutamate-mediated hypoxic injury was investigated in slices of the rat cerebral cortex. Hypoxic injury was determined by mitochondrial reduction of 3-(4,5-dimethyl-2-thiazol)-2,5-diphenyltetrazolium bromide after exposure of brain slices to 30-min of hypoxia/glucose deprivation fo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00814-6
更新日期:2000-09-29 00:00:00
abstract::Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90356-9
更新日期:1983-06-06 00:00:00
abstract:AIMS:Stroke-prone spontaneously hypertensive rats (SHRSP) show significantly lower body weight than normotensive Wistar-Kyoto rats (WKY). Our hypotheses are as follows: weight loss of the skeletal muscle is related to hypertension-related diseases, and muscle hypotrophy is useful as a therapeutic target for hypertensio...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116919
更新日期:2019-11-15 00:00:00
abstract::Excessive fibrosis and extracellular matrix deposition resulting from upregulation of target genes expression mediated by transforming growth factor-beta (TGF-β)/SMAD and hypoxia inducible factor-1 (HIF-1) signaling pathways are the main mechanisms that drive keloid formation. Sumoylation is a protein posttranslationa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117859
更新日期:2020-08-15 00:00:00
abstract::The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different ag...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90416-8
更新日期:1984-08-20 00:00:00
abstract::Using Sokoloff's 2-deoxyglucose (2-DG) autoradiographic technique, the psychotomimetic drug, phencyclidine (PCP, "angel dust") dramatically increased metabolism in diencephalic and telencephalic brain regions known to be rich in high affinity PCP receptors. These effects were greatest in the limbic circuit described i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90116-6
更新日期:1988-01-01 00:00:00
abstract:AIMS:Uric acid nephropathy (UAN) is due to excessive uric acid, which leads to hyperuricemia and kidney damage via the deposition of urate microcrystals in the kidneys. Iridoid glycosides of Paederia scandens (IGPS) is a major active component isolated from the traditional Chinese herb P. scandens (LOUR.) MERRILL (Rubi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.08.013
更新日期:2012-10-05 00:00:00
abstract::Several serotonin (5-HT) receptor antagonists with varying specificities for the 5-HT receptor types, were studied with regard to their effects on blood glucose levels in mice. The non-selective antagonists, metergoline and methysergide, proved to be hyperglycemic at doses commonly used to antagonize 5-HT receptors. I...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90023-5
更新日期:1991-01-01 00:00:00
abstract::The study was designed to investigate the role of molybdenum iron-sulfur flavin hydroxylases in the pathogenesis of liver injuries induced by structurally and mechanistically diverse hepatotoxicants. While carbon tetrachloride (CCl4), thioacetamide (TAA) and chloroform (CHCl3) inflict liver damage by producing free ra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.01.011
更新日期:2008-03-26 00:00:00
abstract::The ability of 2-chloroadenosine (2Cl Ado) to modulate lymphocyte function was examined in culture and in vivo. Mitogenic stimulation of B cell DNA synthesis was antagonized by 2Cl Ado while adenosine produced both stimulations and inhibitions. In culture, 2Cl Ado was found to suppress antibody production to sheep ery...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90648-4
更新日期:1985-07-22 00:00:00
abstract::Puromycin is an experimental anti-tumor antibiotic acting through inhibition of protein synthesis. Because of its untoward side effects (as inner ear and renal lesions) the antibiotic was not approved for clinical trials. The mechanism underlying the organ specificity of the side effect is not understood. In view of t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.10.070
更新日期:2005-06-17 00:00:00
abstract::Asthma is a chronic inflammatory and allergic disease that is mainly characterized by reversible airway obstruction and bronchial hyperresponsiveness. The incidence of asthma is increasing with more than 350 million people worldwide are affected. Up to now, there is no therapeutic option for asthma and most of the pre...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118452
更新日期:2020-11-01 00:00:00
abstract::Gastrin is mitogenic for several colon cancers and is postulated as an autocrine growth factor for colon cancer cells. In the present study we report the development of a simple competitive polymerase chain reaction (PCR) method for measuring relative abundance of gastrin gene expression in colon cancer cells. Primers...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00550-8
更新日期:1994-01-01 00:00:00
abstract::The influence of oral administration of rare earth element cerium (Ce) was studied in relation to metallothionein (MT) and glutathione (GSH) content in the organs of ICR mice, which were administered heavy metal cadmium (Cd) for comparison. Male ICR mice were divided into 9 groups: 1 control group, 4 cerium groups and...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.02.004
更新日期:2005-07-08 00:00:00
abstract::Chymase is an important enzyme for the generation of angiotensin (Ang) II and in the activation of transforming growth factor (TGF)-beta1. Therefore, chymase may be involved in the hemodialysis access dysfunction, which is caused by intimal hyperplasia that occurs after polytetrafluoroethylene (PTFE) graft implantatio...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.09.004
更新日期:2007-09-29 00:00:00
abstract::Macrophages and osteoclasts derive from related cell lines. In osteopetrotic mutants the function of osteoclasts is greatly reduced compared to that in normal animals or children and macrophage function is variably affected depending upon the mutation. To further explore macrophage function in osteopetrosis we examine...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90575-4
更新日期:1989-01-01 00:00:00
abstract::Vascular endothelial cells have been found to produce a relaxant mediator, identified as nitric oxide (NO) and implicated in numerous physiological functions. Subsequently, there has been an intensive search for accurate and specific detection methods to measure biological NO production. In the present study, we compa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00661-9
更新日期:1997-01-01 00:00:00
abstract::The requirement for calcium in the serotonin-mediated aldosterone secretion was investigated using rat adrenal capsular cells. In the calcium-free medium both basal as well as serotonin-stimulated aldosterone secretion (at concentrations of 10(-7) M and 10(-8) M of serotonin) were significantly impaired. The effects o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90053-0
更新日期:1985-04-15 00:00:00
abstract:AIMS:In this study, we conducted a meta-analysis to systematically compare the diagnostic accuracy of IGRAs performed for extrasanguinous body fluids with that performed for blood in the diagnosis of TB. MAIN METHODS:Multiple English and Chinese databases were searched up to November 2017. Studies that complied with t...
journal_title:Life sciences
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.lfs.2018.02.004
更新日期:2018-03-15 00:00:00
abstract::Single unit recordings were obtained from putative dopaminergic neurons in the substantia nigra of awake, freely moving rats. The cells exhibited waveforms, range of firing rates and types of firing patterns identical to those of identified DA neurons of anesthetized or paralyzed rats. Two firing patterns were observe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90448-5
更新日期:1985-05-20 00:00:00