Steroidogenic effect of ent-kaur-16-en-15 beta-ol (kaurenol) on isolated rat adrenal cells.

abstract：:In a series of in vitro experiments we characterised the relationship between DNA distribution in the G1, S and G2/M phases of cell cycle and PDE and GST activity in CaCo-2 cells. The DNA distribution in CaCo-2 cells, was assessed by flow cytometry, with fluorescent dyes at different time points of culture. The expone...

journal_title：Life sciences

authors： Savini F,Berardi S,Tatone D,Spoto G

更新日期：1995-01-01 00:00:00

abstract：:Withania somnifera (ashwagandha, Indian ginseng) is an immunostimulant herbal medicine used to improve overall health and prevent diseases, particularly in the elderly. However, the mechanisms underlying its immunostimulant effect is poorly understood. To elucidate the mechanism of Withania somnifera, we investigated ...

journal_title：Life sciences

authors： Iuvone T,Esposito G,Capasso F,Izzo AA

更新日期：2003-02-21 00:00:00

abstract：:The effects of 100 microM norepinephrine (NE), GABA, aspartate, glutamate, and carbachol on the release of endogenous NE, GABA, aspartate, and glutamate from slices of rat cerebellum were examined. The 35 mM K+-stimulated release of NE was potentiated by GABA (136% of control), glutamate (123%), and carbachol (123%); ...

journal_title：Life sciences

authors： Flint RS,McBride WJ

更新日期：1986-01-20 00:00:00

abstract：:The effects of muscarinic and alpha-adrenergic receptor stimulation on phosphoinositide turnover in rat atria have been compared. Despite the similar densities of muscarinic receptors in rat left and right atria, 0.1 mM carbachol increased [32P]phosphate incorporation into phosphatidylinositol (PI) by 35% (p less than...

journal_title：Life sciences

authors： Sekar MC,Roufogalis BD

更新日期：1984-10-01 00:00:00

abstract：AIMS:Head and neck squamous cell carcinoma (HNSCC) is an highly aggressive tumor with heterogeneous prognosis. We here report that immune-related genes (IRGs) could effectively distinguish prognostically different HNSCC patients. MATERIALS AND METHODS:MRNA levels of 1333 IRGs that from ImmPort database in HNSCC sample...

journal_title：Life sciences

authors： Yang J,Xie K,Li C

更新日期：2020-09-01 00:00:00

abstract：AIMS:Smooth muscle cells (SMCs) play a role in medial vascular calcification, which can be stimulated by high levels of serum phosphate and inflammatory mediators. The aim of this study was to investigate whether mitogen-activated protein kinases (MAPKs) (p38 MAPK, ERK1/2, and JNK) and protein kinase A (PKA) can partic...

journal_title：Life sciences

authors： Toita R,Otani K,Kawano T,Fujita S,Murata M,Kang JH

更新日期：2018-09-15 00:00:00

abstract：:The purpose of this investigation was to determine the effects of experimental dicrocoeliosis on bile formation in the hamster. Studies were carried out at 120 days after infection with an oral dose of 40 metacercariae of Dicrocoelium dendriticum. A significant elevation in bile flow (+20%) and in the biliary output o...

journal_title：Life sciences

authors： Sánchez-Campos S,Tuñón MJ,González P,Marín JJ,González-Gallego J

更新日期：1998-01-01 00:00:00

abstract：:Nephrotoxicity is a limiting factor in the use of ifosfamide in children. Despite the co-administration of uroprotective agents such as sodium 2-mercaptoethanesulfonate (mesna), ifosfamide chemotherapy is associated with nephropathy characterized by glomerular toxicity and Fanconi syndrome in many children treated wit...

journal_title：Life sciences

authors： Woodland C,Ito S,Granvil CP,Wainer IW,Klein J,Koren G

更新日期：2000-11-24 00:00:00

abstract：:A response in heat shock protein 70 (hsp 70) expression in the beta-naphthoflavone (BNF) treated rainbow trout (Oncorhynchus mykiss) corresponded to altered metabolic status of the liver as evidenced by the lower phosphoenolpyruvate carboxykinase (PEPCK), lactate dehydrogenase and 3-hydroxyacylcoA dehydrogenase activi...

journal_title：Life sciences

authors： Vijayan MM,Pereira C,Forsyth RB,Kennedy CJ,Iwama GK

更新日期：1997-01-01 00:00:00

abstract：:The scientific interest in irisin, a myokine discovered in 2012, has grown exponentially in recent years. Irisin, which is mainly produced in skeletal muscle, influences the browning process of adipose tissue and lipid and energy metabolism. Recent discoveries highlight that the potential of this hormone may have been...

journal_title：Life sciences

authors： Flori L,Testai L,Calderone V

更新日期：2021-02-15 00:00:00

abstract：:The opioid peptides [Met] enkephalin-Arg6-Phe7, [Met]-enkephalin-Arg6-Gly7-Leu8, and BAM-12P were identified in various ares of human brain by use of a combination of radioimmunoassay (RIA), gel filtration, and high performance liquid chromatography (HPLC). The highest levels of each peptide were found in striatum, fo...

journal_title：Life sciences

authors： Pittius CW,Seizinger BR,Mehraein P,Pasi A,Herz A

更新日期：1983-01-01 00:00:00

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...

journal_title：Life sciences

authors： Hossein-Khannazer N,Hashemi SM,Namaki S,Ghanbarian H,Sattari M,Khojasteh A

更新日期：2019-01-01 00:00:00

abstract：:The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-day...

journal_title：Life sciences

authors： McDougall SA,Neisewander JL,Bardo MT,Zolman JF

更新日期：1989-01-01 00:00:00

abstract：:Previous investigations showed that chronic metabolic acidosis (CMA) increased the paracellular permeability of ion and neutral hydrophilic molecules in the duodenum of rats and small intestinal-like cell lines. Since proteins of the claudin family have been known to regulate the paracellular transport in several epit...

journal_title：Life sciences

authors： Charoenphandhu N,Wongdee K,Tudpor K,Pandaranandaka J,Krishnamra N

更新日期：2007-04-17 00:00:00

abstract：:The relative potencies of the in vivo vasodilating effect on the arterioles of the hamster cheek pouch of morphine and beta-endorphin decreased significantly after chronic morphine injection, indicating the existence of tolerance to morphine and cross tolerance between morphine and beta-endorphin. The apparent pA2 val...

journal_title：Life sciences

authors： Koo A,Wong TM

更新日期：1983-01-31 00:00:00

abstract：AIMS:To potentiate the well-documented tumor protecting ability of paullones, literatures demand for rational modifications in paullone ring structure and exploration of a precise mechanism underlying their antitumor effects. Thus, recently we synthesized novel paullone-like scaffold, 5H-benzo [2, 3][1,4]oxazepino[5,6-...

journal_title：Life sciences

authors： Singh AK,Bhadauria AS,Kumar U,Raj V,Maurya V,Kumar D,Maity B,Prakash A,De A,Samanta A,Saha S

更新日期：2018-05-15 00:00:00

abstract：:Acetylcholine (ACh) may be an ovarian signaling molecule, since ACh is produced by non-neuronal granulosa cells (GCs) derived from the antral follicle, and likely also by their in vivo counterparts in the growing follicle. Furthermore, muscarinic ACh receptors (MR) are present in GC membranes and in cultured human GCs...

journal_title：Life sciences

authors： Kunz L,Roggors C,Mayerhofer A

更新日期：2007-05-30 00:00:00

abstract：:Cultured adult skin fibroblasts were studied for binding and functional evidence of muscarinic receptors in order to assess their utility as a model of cholinergic function in affective illness. Saturable, specific, high affinity binding could be demonstrated in intact cells from some cell lines with [3H]-NMS, but not...

journal_title：Life sciences

authors： Kelsoe JR Jr,Gillin JC,Janowsky DS,Brown JH,Risch SC,Lumkin B

更新日期：1986-04-14 00:00:00

abstract：:Ischemia-reperfusion of organs such as the kidney produces reactive oxygen and free radical species in tissues and leads to injury of intracellular molecules critical to cell homeostasis. Ischemia-reperfusion affects the NADPH-dependent monooxygenase system including P450 system, which is also a source of reactive oxy...

journal_title：Life sciences

authors： Tamura Y,Imaoka S,Gemba M,Funae Y

更新日期：1997-01-01 00:00:00

abstract：:The effect of resveratrol, a polyphenolic compound present in grapes and other plants, on proteinuria, hypoalbuminemia and hyperlipidemia was studied in rats with glomerulonephritis. The nephritis was induced by an intravenous injection of anti-rat kidney glomerular basement membrane rabbit antiserum. Nephritic rats w...

journal_title：Life sciences

authors： Nihei T,Miura Y,Yagasaki K

更新日期：2001-05-11 00:00:00

abstract：:Recent studies have demonstrated that the majority of muscarinic receptors in rabbit peripheral lung homogenates bind pirenzepine with high affinity (putative M1 subtype). In experiments of AF-DX 116 inhibiting [3H](-)quinuclidinyl benzilate or [3H]pirenzepine, we found similar inhibitory constants for AF-DX 116 bindi...

journal_title：Life sciences

authors： Bloom JW,Halonen M,Seaver NA,Yamamura HI

更新日期：1987-07-27 00:00:00

abstract：:Uptake of serotonin and 3H-imipramine binding in platelets of depressed patients were investigated simultaneously with changes in clinical state. Both Vmax for serotonin uptake and Bmax for 3H-imipramine binding were significantly lower in unmedicated depressed patients with respect to normal subjects. Successful trea...

journal_title：Life sciences

authors： Suranyi-Cadotte BE,Quirion R,Nair NP,Lafaille F,Schwartz G

更新日期：1985-02-25 00:00:00

abstract：AIMS:Baicalein is a widely used Chinese herbal medicine extracted from Labiatae plants Scutellaria baicalensis Georgi's dry root, which has multiple pharmacological activities. However, the precise mechanism of baicalein against myocardial remodeling remains poorly understood. The aim of our study was to investigate th...

journal_title：Life sciences

authors： Zhao F,Fu L,Yang W,Dong Y,Yang J,Sun S,Hou Y

更新日期：2016-01-15 00:00:00

abstract：:The role of K+ channels in the relaxations induced by bradykinin, lemakalim, an activator of ATP-sensitive K+ channels and sodium nitroprusside (SNP), a nitric oxide (NO) donor was examined in the isolated mouse trachea precontracted by methacholine (1 microM). 4-aminopyridine (4-AP, 0.1-2 mM), an inhibitor of 4-AP se...

journal_title：Life sciences

authors： Li L,Vaali K,Paakkari I,Vapaatalo H

更新日期：1997-01-01 00:00:00

abstract：:Diabetic retinopathy, a common secondary complication of diabetes mellitus, involves extensive damage to the retinal microvasculature. Retina, being a susceptible target, is highly prone to hyperglycemia-induced molecular damages. PPAR receptor, chiefly gamma subtype, mediates numerous responses related to glucose met...

journal_title：Life sciences

authors： Behl T,Kaur I,Goel H,Kotwani A

更新日期：2016-05-15 00:00:00

abstract：:Bile duct ligation (BDL) in rats induces portal fibrosis. This process has been linked to changes in the oxidative state of the hepatic cells and in the production of nitric oxide. Our objective was to find possible temporal connections between hepatic redox state, NO synthesis and liver injury. In this work we have c...

journal_title：Life sciences

authors： Vázquez-Gil MJ,Mesonero MJ,Flores O,Criado M,Hidalgo F,Arévalo MA,Sánchez-Rodríguez A,Tuñón MJ,López-Novoa JM,Esteller A

更新日期：2004-06-25 00:00:00

abstract：:The aims of the current study were: 1) to determine if the epsilonPKC pseudosubstrate peptide (epsilonphi) (NH(2)-RKRQGAVRRRVHQVNG-COOH) could be used as an epsilonPKC-selective inhibitor in neonatal cardiac myocytes (NCMs) and 2) to determine if differences in the alpha and epsilonPKC autoinhibitory pseudosubstrate m...

journal_title：Life sciences

authors： Johnson JA

更新日期：2004-05-07 00:00:00

abstract：:Low pH medium has been shown to activate the 'efferent' function of capsaicin-sensitive primary sensory neurons. Calcitonin gene-related peptide (CGRP) is released from capsaicin-sensitive afferents of guinea-pig superior sagittal and transverse sinuses (SSTS), by capsaicin or bradykinin. Here, we report that low pH m...

journal_title：Life sciences

authors： Fanciullacci M,Tramontana M,Del Bianco E,Alessandri M,Geppetti P

更新日期：1991-01-01 00:00:00

abstract：:Anorexia, nausea/emesis and peripheral sensorial neuropathy are frequent adverse effects associated with chemotherapy. Cannabinoids have been proposed to alleviate these effects, but their preventive properties in long-term experimental models have not been tested. This study was conducted to determine whether or not ...

journal_title：Life sciences

authors： Vera G,Chiarlone A,Cabezos PA,Pascual D,Martín MI,Abalo R

更新日期：2007-07-19 00:00:00