Abstract：
:Anorexia, nausea/emesis and peripheral sensorial neuropathy are frequent adverse effects associated with chemotherapy. Cannabinoids have been proposed to alleviate these effects, but their preventive properties in long-term experimental models have not been tested. This study was conducted to determine whether or not a cannabinoid agonist (WIN-55,212-2) can prevent anorexia, pica (an indirect marker of nausea in non-vomiting species, consisting of the ingestion of non-nutritive substances such as kaolin) and mechanical allodynia (a marker of peripheral neuropathy) induced by the antineoplastic drug cisplatin chronically administered. Isolated rats with free access to food and kaolin received either saline, cannabinoid vehicle, WIN-55,212-2 (1-2 mg kg(-1)), cisplatin (1-2 mg kg(-1)), or both drugs once per week for five consecutive weeks. Modifications in temperature, body weight gain, food and kaolin intake, and the threshold for mechanical allodynia were recorded. Additionally, the acute psychoactive effects of the cannabinoid (hypomotility, hypothermia, analgesia and catalepsia) were assayed by means of the cannabinoid tetrad. WIN 55,212-2 prevented the development of mechanical allodynia but not anorexia, pica and reduction in weight gain induced by chronic cisplatin. The effect of WIN 55,212-2 was evident even at a dose lacking activity in the cannabinoid tetrad. The preventive effect on cisplatin-induced mechanical allodynia exerted by the cannabinoid could be due to a neuroprotective role, as has been suggested for other conditions. The present results support the interest in the evaluation of cannabinoids for treatment of patients suffering or likely to suffer neuropathic pain.
journal_name
Life Scijournal_title
Life sciencesauthors
Vera G,Chiarlone A,Cabezos PA,Pascual D,Martín MI,Abalo Rdoi
10.1016/j.lfs.2007.06.012subject
Has Abstractpub_date
2007-07-19 00:00:00pages
468-79issue
6eissn
0024-3205issn
1879-0631pii
S0024-3205(07)00476-6journal_volume
81pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：AIMS:To examine the role of trypsin in the immune response of macrophages and to determine whether protease-activated receptors (PARs) are involved in the effects of trypsin. MAIN METHODS:We used RAW264.7 cells and peritoneal macrophages isolated from C57BL/6 wild-type mice, PAR2 knockout mice, and ddY mice. Macrophag...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.06.030
更新日期：2012-08-21 00:00:00
abstract：AIMS:We investigated the involvement of the renin angiotensin system (RAS) on the cardiorespiratory control in rats from dams fed with a low-protein diet. MAIN METHODS:Male offspring were obtained from dams fed a normoprotein diet (NP, 17% casein) and low-protein diet (LP, 8% casein) during pregnancy and lactation. Di...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118574
更新日期：2020-12-15 00:00:00
abstract：AIMS:The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. MAIN METHODS:Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 24h after injection of the sarcoma cells in the hind paw (s.c.). Mice were evaluated for mechanical s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.08.020
更新日期：2014-10-22 00:00:00
abstract：:Prenatal exposure to low concentrations of carbon monoxide (CO, 75 and 150 ppm from day 0 to day 20 of gestation), resulting in maternal blood HbCO concentrations equivalent to those maintained by human cigarette smokers, leads to subtle myelin alterations in the sciatic nerve of male rat offspring. The rapid growth s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00761-x
更新日期：2000-08-25 00:00:00
abstract：:Anandamide (arachidonylethanolamide; AEA) is an endogenous ligand for the cannabinoid receptor and its pharmacological effects are under intensive study. However, AEA has a low aqueous solubility and stability which may restrict its use and may eventually endanger the reliability of the obtained results. In the presen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00024-0
更新日期：1996-01-01 00:00:00
abstract：:The effect of cadmium (Cd2+) was studied in vitro on the flavokinase (ATP : riboflavin 5'-phosphotransferase, EC 2.7.1.26) activity purified from rat liver. Cadmium inhibited flavokinase activity in a concentration-dependent manner and the effect was completely reversed by increasing concentration of zinc (Zn2+), indi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00151-3
更新日期：1997-01-01 00:00:00
abstract：:Glucocorticoid receptors (GR) are ubiquitous molecules and are present also in the hippocampus and in several other nervous and immune tissues. Peripheral blood mononuclear cells (PBMCs) are a good model for studies of GR in humans. Glucocorticoids are important for maintaining cellular and humoral homeostasis and are...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00386-x
更新日期：1997-01-01 00:00:00
abstract：:In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00328-2
更新日期：1998-01-01 00:00:00
abstract：:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90183-7
更新日期：1982-10-18 00:00:00
abstract：:Plasma and urinary levels of MHPG were determined in six normal volunteers. Samples were obtained at 3-hour intervals for plasma and at 12-hour intervals for urine. Acrophase, amplitude and period were determined for plasma MHPG levels. A sinusoidal pattern was obtained for diurnal plasma MHPG with a peak at 15:00 hrs...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90302-9
更新日期：1985-11-04 00:00:00
abstract：:The effects of chronic treatment with antidepressants, verapamil, or lithium on serotonin (5-HT)-induced Ca2+ increase were investigated in single C6BU-1 glioma cells with digital imaging microscopy. Clomipramine and citalopram, at a concentration of 100 nM, decreased the peak values of 5-HT-induced [Ca2+]i changes. V...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00010-6
更新日期：1997-01-01 00:00:00
abstract：:Ketamine, used clinically as an intravenous analgetic and dissociative anaesthetic agent, is a racemate with both pharmacokinetic and pharmacodynamic enantioselectivity. S-ketamine has been found have a higher clearance and greater potency than R-ketamine as well as a greater therapeutic index. We performed a study in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01287-5
更新日期：2001-09-14 00:00:00
abstract：:The O2 affinity of "stripped" (cofactor-free) hemoglobin (Hb) of the elasmobranch, Squalus acanthias is decreased by ATP, the main erythrocytic phosphate cofactor but increased by urea at physiological concentration. When both compounds are present, as in life, urea decreases the ATP sensitivity, indicating that previ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90105-4
更新日期：1983-05-02 00:00:00
abstract：AIMS:The objective of this study was to establish a more accurate analytical model and method for grip strength test of mice and to investigate the beneficial effects of lifelong exercise training to prevent functional decline of muscle during aging. MAIN METHODS:Fifty randomly selected adult male BALB/c mice (24-56 w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117603
更新日期：2020-06-15 00:00:00
abstract：:Hyperglycemia and oxidative stress are the primary stressors that elicit mitochondria specific cell stress in diabetes. Here we hypothesized that elevated level of ROS in high glucose (HG) environment, trigger mitochondrial stress by damaging mitochondrial DNA (mtDNA), altering inflammatory mediators, and neurodegener...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117914
更新日期：2020-09-01 00:00:00
abstract：:We explored the mechanism whereby maltitol causes an increase of calcium absorption in the lower small intestine using everted ileal segments of rats. Under the calcium concentrations tested (1-20mM), which enabled us to assess the diffusional calcium transfer, maltitol in the mucosal-side medium (100mM) caused a 155%...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00430-4
更新日期：1996-01-01 00:00:00
abstract：:In view of the toxicity of cocaine and recent reports on the antimuscarinic properties of cocaine, the present study evaluated the effects of manipulations in cholinergic neurotransmission on the lethal effects of cocaine. Physostigmine pretreatment significantly altered the lethality of cocaine, increasing the LD 50 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90111-2
更新日期：1989-01-01 00:00:00
abstract：:A number of experimental studies report that biological systems can be affected by in vivo exposure to low frequency and extremely low frequency electromagnetic fields. However, attempts to independently replicate some of these studies have shown the reported effects to be elusive. The difficulty in replicating result...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00770-4
更新日期：1997-01-01 00:00:00
abstract：:The effects of morphine-3-glucuronide (M3G) and morphine on the K+-evoked release of [14C]-gamma-aminobutyric acid (GABA) and [3 H]-glutamic acid were investigated in rat brain synaptosomes using superfusion techniques. K+-evoked release of both [14C]-GABA and [3H]-glutamic acid from rat brain synaptosomes was elimina...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02310-0
更新日期：1996-01-01 00:00:00
abstract：:Using a dipole tracing method based on the two-dipole model, the purpose of the present study was to investigate alcohol-induced changes in the alpha band of electroencephalogram (EEG) and its equivalent current dipoles (ECDs) in 12 healthy male volunteers, who were genetically typed for mitochondrial aldehyde dehydro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00707-4
更新日期：2000-01-01 00:00:00
abstract：:Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of L-dihydroxyphenylalanine (L-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00275-6
更新日期：1998-01-01 00:00:00
abstract：AIMS:The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.03.053
更新日期：2016-05-01 00:00:00
abstract：:18-Hydroxycorticosterone (18-OHB) is a precursor of aldosterone and is the only corticosteroid, other than aldosterone, that is synthesized predominantly in the zona glomerulosa. Administration of the dopamine antagonist, metoclopramide results in parallel rises in plasma 18-OHB and aldosterone levels without affectin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90157-1
更新日期：1983-12-19 00:00:00
abstract：AIMS:The purpose of this study was to investigate mechanisms of chronic alcohol-induced cardiac remodeling and dysfunction. We also sought to determine the role of cardiac fibroblasts, which play a dynamic role in cardiac remodeling, in mediating these effects. MAIN METHODS:Adult male Wistar rats were exposed to ethan...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117330
更新日期：2020-03-15 00:00:00
abstract：:The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mix...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00645-5
更新日期：1997-01-01 00:00:00
abstract：AIMS:The natural phenolic oil compound hydroxytyrosol (HTy) is widely studied because of its antioxidant and neuroprotective properties. Nitroderivatives of HTy have been studied in order to evaluate their putative effects on catechol-O-methyltransferase (COMT) activity. MAIN METHODS:To study its effect on dopamine me...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.04.026
更新日期：2015-08-01 00:00:00
abstract：:Dehydroepiandrosterone (DHEA), an adrenal steroid of no known biological function, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). DHEA inhibited the growth of two stains of HeLa and WI-38 cells in culture. One of the HeLa strains, TCRC-2, was about 10x as sensitive to growth inhibition a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90557-6
更新日期：1986-04-21 00:00:00
abstract：:Previous studies have shown that cytochrome P450-Arachidonic Acid (P450-AA) metabolites modify the vascular tone of several vessels and that vasopressin (AVP) stimulates P450-AA metabolism. Thus, in the present study, we decided to investigate if the vasoconstrictor effect of AVP is related to activation of P450-AA me...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00108-i
更新日期：1995-01-01 00:00:00
abstract：:Although exogenous cannabinoid ligands such as delta9-tetrahydrocannabinol (THC) have been implicated in reward-related learning and aversion, the hedonic effects of the endogenous cannabinoid agonist anandamide (arachidonylethanolamide) have never been assessed. Thus, the effects of anandamide were tested in a place ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00226-4
更新日期：1998-01-01 00:00:00
abstract：AIMS:Enhancing myogenesis has been identified as a possible target to improve insulin sensitivity and protect against metabolic diseases. Catalpol, an iridoid glycoside, has been shown to exert a hypoglycaemic effect by improvement of insulin sensitivity; however, the underlying mechanism remains unknown. In this study...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.028
更新日期：2018-09-15 00:00:00
