Abstract：
:Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymatic activity of glutathione reductase is rapidly destroyed. Implications of these findings for a regulatory role of hemin in cell biology are discussed.
journal_name
Life Scijournal_title
Life sciencesauthors
Aft RL,Mueller GCdoi
10.1016/0024-3205(85)90312-1subject
Has Abstractpub_date
1985-06-03 00:00:00pages
2153-61issue
22eissn
0024-3205issn
1879-0631pii
0024-3205(85)90312-1journal_volume
36pub_type
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