Abstract：
:14C-Imipramine was administered to male and female Sprague-Dawley rats and animals were sacrificed at 4, 8, 12, and 20 hours later. At all time points, total radioactivity in female lung was several-fold higher than in males. In addition, female lungs had a higher concentration of desmethylimipramine (DMI) as compared to imipramine than did male rat lungs. This was reflected by a higher conversion of imipramine to DMI by hepatic and pulmonary microsomes from female rats. Finally male rats cleared both imipramine and DMI from their lungs at a slower rate than did female rats.
journal_name
Life Scijournal_title
Life sciencesauthors
Ginsburg E,Hirokata Y,Gram TEdoi
10.1016/0024-3205(82)90610-5subject
Has Abstractpub_date
1982-03-01 00:00:00pages
757-60issue
9eissn
0024-3205issn
1879-0631pii
0024-3205(82)90610-5journal_volume
30pub_type
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