Abstract：
:Advanced chronic kidney disease is associated with high rates of cardiovascular disease. Considering the crucial role of capillaries in renal function, our study aimed to evaluate microparticles related to vascular physiology examining the link between stages of chronic kidney disease with circulating endothelial (EMP), platelet (PMP) and monocytic (MMP) microparticles. Cross-sectional study with blinded endpoints included subjects of both sexes, aged 40-75 years (n = 247), with established cardiovascular disease (coronary heart disease, ischemic stroke, or peripheral artery disease). They were stratified 1:1 by the presence or absence of decreased glomerular filtration rate (GFR < 60 mL/min/1.73 m2) estimated by the CKD-EPI criteria, and according to the stages of CKD. Microparticles were quantified by flow-cytometry using specific antibodies to identify endothelial, platelet, and monocytic derived microparticles. Higher percentages of circulating MMP (p = 0.036), but not for EMP or PMP, were observed in subjects with reduced GFR. Circulating MMP were also related to the stages of chronic kidney disease (trend analysis across renal stages, p = 0.038). Higher percentages of circulating MMP were found in subjects with reduced GFR, and their percentages were progressively higher according to the stage of chronic renal function.
journal_name
Life Scijournal_title
Life sciencesauthors
Fonseca F,Ballerini AP,Izar MC,Kato J,Ferreira CE,Fonzar W,do Amaral J,Rezende P,Machado-Santelli G,França Cdoi
10.1016/j.lfs.2020.118295subject
Has Abstractpub_date
2020-11-01 00:00:00pages
118295eissn
0024-3205issn
1879-0631pii
S0024-3205(20)31047-Xjournal_volume
260pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:A simple and sensitive method using high performance liquid chromatography with fluorometric detection has been developed for the identification and quantitation of the endogeneous tryptamine metabolites, indoleacetic acid (IAA) and tryptophol (TOL) in the normal mouse brain. The limits of sensitivity are 5pg for both...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90744-0
更新日期：1983-11-14 00:00:00
abstract：:Oxidative stress induced cell injury is reported to contribute to the pathogenesis of cerebral ischemia. Reactive oxygen species such as hydrogen peroxide (H2O2) and superoxide radical along with nitric oxide and peroxynitrite generated during ischemia-reperfusion injury, causes the overactivation of poly (ADP-ribose)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.07.034
更新日期：2006-11-10 00:00:00
abstract：:The effect of silymarin on different functions of mitochondria isolated from rat kidneys was studied. Addition of silymarin to mitochondria oxidizing succinate, induced stimulation of the respiratory State 4; while in mitochondria oxidizing NAD-dependent substrates, the drug produced inhibition of the oxygen consumpti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90542-5
更新日期：1988-01-01 00:00:00
abstract：:Asthma is a chronic inflammatory and allergic disease that is mainly characterized by reversible airway obstruction and bronchial hyperresponsiveness. The incidence of asthma is increasing with more than 350 million people worldwide are affected. Up to now, there is no therapeutic option for asthma and most of the pre...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118452
更新日期：2020-11-01 00:00:00
abstract：AIM:Beta asarone is the major constituent of oil obtained from Acorus calamus, the Indian traditional medicine plant. Several studies have shown that beta asarone causes liver and cardiac damages but the reproductive toxicity is not well understood. The present study was initiated to investigate whether beta asarone ha...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.08.021
更新日期：2017-03-15 00:00:00
abstract：:The N-terminus portion of the POMC leader sequence (signal peptide) was synthesized, and an antiserum was raised against it. A radioimmunoassay was developed which is effective at a dilution of 1:500,000, and sensitive at less than 1 fmole/tube. Since leader sequences often exhibit structural homologies, and since syn...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90135-7
更新日期：1982-11-15 00:00:00
abstract：:We reported previously that acetylcholine (ACh)-induced endothelium-dependent relaxation of rat mesenteric microvessels depended both on nitric oxide (NO) and on a charybdotoxin (CTX)-sensitive endothelium-derived hyperpolarizing vasodilator. Cytochrome P450 (CYP)-dependent arachidonic acid metabolites act in some sys...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00413-6
更新日期：2000-02-11 00:00:00
abstract：AIMS:Gastric cancer (GC) is one of the most common malignant tumors in the world. Anti-angiogenic therapy is a useful strategy for the treatment of advanced GC. This study was aimed to systemically compare the anti-angiogenesis, anti-cancer efficacy, as well as the safety of four known anti-angiogenic drugs, namely ram...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117402
更新日期：2020-04-15 00:00:00
abstract：AIMS:The effects of chronic administration of Ferutinin (phytoestrogen found in the plants of genus Ferula), compared with those elicited by estradiol benzoate, were evaluated, following ovariectomy, on the uterus of ovariectomized rats as regard weight, size, structure and histomorphometry. MAIN METHODS:The experimen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.11.001
更新日期：2012-01-16 00:00:00
abstract：:Grape seed extract (GSE) is a commonly available dietary supplement taken for the anti-oxidant activity that's attributed to its proanthocyanidin (oligomers of monomeric polyphenols) content. Similar polyphenol-enriched preparations from blueberries and soy have shown protection against ovariectomy-induced or age-rela...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.12.008
更新日期：2006-03-27 00:00:00
abstract：:Rats were exposed for ten months to 60 ppm of lead (Pb, as acetate) in drinking water to further assess cardiovascular effects of chronic Pb exposure. At the end of the treatment, mean blood Pb was 3.1+/-0.3 microg/dL in the control rats and 22.8+/-1.2 microg/dL in the Pb-exposed rats (means+/-SE, n=12 in each group);...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00954-1
更新日期：2000-12-15 00:00:00
abstract：:NSAIDs can elevate blood pressure through mechanisms such as renal vasoconstriction and sodium retention. These effects are particularly evident in hypertensive individuals. Nitric oxide-releasing NSAID derivatives have been shown to have greatly reduced toxicity in the gastrointestinal tract and kidney. We therefore ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00072-1
更新日期：1998-01-01 00:00:00
abstract：:Propentofylline (PPF) is a xanthine derivative with pharmacological effects that are distinct from those of classic methylxanthines. It depresses the activation of microglial cells and astrocytes, which is associated with neuronal damage during neural inflammation and hypoxia. Our previous studies showed that PPF impr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.028
更新日期：2016-03-01 00:00:00
abstract：:Elevated levels of serum free fatty acids (FFA) may be the metabolic alteration in obesity that leads to insulin resistance (IR) and type 2 diabetes mellitus (DM). The obese Zucker rat (ZR) is a genetic model of juvenile-onset obesity and type 2 DM. Compared with its lean sibling, the obese ZR is hyperinsulinemic, hyp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01345-5
更新日期：2001-10-19 00:00:00
abstract：AIMS:Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period. MAIN METHODS:A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.033
更新日期：2018-09-15 00:00:00
abstract：:The secretagogue action of lipophilic, GABA-mimetic, beta-(p-chlorophenyl)-gamma-aminobutyric acid (PCPGABA) was studied in the rat in relation to body temperature. PCPGABA (2 to 8 mg/kg s.c.) stimulated acid output in the urethane-anesthetized rat whose core temperature ranged between 28 to 30 degrees C. However, thi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90144-g
更新日期：1990-01-01 00:00:00
abstract：:Administration of ovine-prolactin (O-PRL) stimulated Ca2+ uptake in isolated duodenal cells prepared from vitamin D-deficient rats. The time course of this effect was biphasic: uptake activity reached a peak in 2.5 hrs followed by a decrease at 5 hrs to original levels. This stimulatory effect of O-PRL was observed in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90568-c
更新日期：1990-01-01 00:00:00
abstract：:It has been shown that the main psychoactive component of marihuana, delta9-tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its s...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(99)00292-1
更新日期：1999-01-01 00:00:00
abstract：:The present report investigated whether percentages of circulating natural killer (NK) cells and NK cell activity (NKCA) are associated with psychological variables. Subjects (n = 95) were selected, based on a combination of low or high scores on questionnaires on daily hassles and self-reported symptoms, to create fo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90002-k
更新日期：1993-01-01 00:00:00
abstract：:In this study, we evaluated whether butein can inhibit the effects of tumor necrosis factor alpha (TNF-alpha), an inflammatory mediator, in intestinal epithelial HT-29 cells. Butein significantly inhibited TNF-alpha-induced interleukin 8 (IL-8) secretion and mRNA expression. Moreover, butein suppressed the expression ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.09.024
更新日期：2007-11-10 00:00:00
abstract：:The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90076-8
更新日期：1988-01-01 00:00:00
abstract：:The lymphatic vessels have been implicated in maintenance of interstitial fluid homeostasis and immune responses, and pathological conditions including inflammation, wound healing, lymphedema and tumor progression. The knowledge about the lymphatic structure and function in muscles, especially in muscular disorders, r...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.09.043
更新日期：2018-10-15 00:00:00
abstract：:The human eye being a complex and a very sensitive organ makes the drug delivery task challenging. An increase in the intra-ocular pressure at the aqueous humour leads to glaucoma which is not only indecipherable but can also be the reason of blindness for many. The presently available marketed formulations using anti...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2019.02.029
更新日期：2019-03-15 00:00:00
abstract：:Using a dipole tracing method based on the two-dipole model, the purpose of the present study was to investigate alcohol-induced changes in the alpha band of electroencephalogram (EEG) and its equivalent current dipoles (ECDs) in 12 healthy male volunteers, who were genetically typed for mitochondrial aldehyde dehydro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00707-4
更新日期：2000-01-01 00:00:00
abstract：:The loss of osteoblast function in aging bone is one of the major causes of osteopenia, or loss of bone mass. In this study, this loss of function was investigated by examining the proliferative response of rat long bone periosteal osteoblasts to TGF(beta1) and 1,25-dihydroxy vitamin D(3) (1,25-D(3)) as a function of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01548-5
更新日期：2002-05-10 00:00:00
abstract：:This work explored cellular trapping and extrusion of Cd and Hg in epithelial cells, with special emphasis on the jejunal mucosa. Important determinants of these processes are the concentration, diffusibility and relative metal affinities of a variety of cellular metal-binding compounds including metallothionein (MT)....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90042-2
更新日期：1993-01-01 00:00:00
abstract：:The effects of GABA antagonists, picrotoxin and bicuculline were studied on hyperphagia caused by insulin in free feeding rats. It was found that peripheral administration of GABA antagonists inhibited this hyperphagia. These agents were administered in the VMH and LH through stereotaxically implanted cannulae. It was...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90220-0
更新日期：1984-06-04 00:00:00
abstract：:Aminoalkylindoles (AAIs) are structurally dissimilar from the classical cannabinoids (CCs), however, both AAIs and CCs appear to bind at the same site on the cannabinoid receptor. To obtain better insights on the structural correlation between AAIs and CCs, we have studied the conformational properties of the potent c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00177-8
更新日期：1995-01-01 00:00:00
abstract：:Rats were given the basic lipophilic drug, phenoxybenzamine, in single i.v. doses of 0.4 and 30 mg/kg. The drug was determined in plasma and 7 tissues by a new HPLC method. Adipose tissue reached peak levels after 30 minutes. At that time levels in heart, kidney, and brain were higher than in subcutaneous, epididymal,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90478-4
更新日期：1987-10-26 00:00:00
abstract：:The ability of 2-chloroadenosine (2Cl Ado) to modulate lymphocyte function was examined in culture and in vivo. Mitogenic stimulation of B cell DNA synthesis was antagonized by 2Cl Ado while adenosine produced both stimulations and inhibitions. In culture, 2Cl Ado was found to suppress antibody production to sheep ery...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90648-4
更新日期：1985-07-22 00:00:00
