Glaucoma: Current treatment and impact of advanced drug delivery systems.

abstract：:In this study, we have characterized quinone reductase (QR), glutathione (GSH), glutathione S-transferase (GST) and their induction by a chemoprotector, 1,2-dithiole-3-thione (D3T), in the human myeloid cell lines ML-1 and HL-60. In addition, we also examined the toxicity of hydroquinone (HQ), a benzene metabolite, to...

journal_title：Life sciences

authors： Li Y,Lafuente A,Trush MA

更新日期：1994-01-01 00:00:00

abstract：:DL-alpha-difluoromethylornithine (DFMO), 4-deoxypyridoxine (4-DOP), and methylglyoxal bis (guanylhydrazone) (MGBG) were tested as inhibitors of acute skin graft rejection. Proximal full thickness tail skins were exchanged between C57BL/6 and Balb/C mice. Distal autografts were placed to monitor healing. Inhibitors wer...

journal_title：Life sciences

authors： Campbell RA,Kurtz GL,Norton-Reel DJ

更新日期：1991-01-01 00:00:00

abstract：:Ocimum sanctum, the Indian holy basil, has significant ability to scavenge highly reactive free radicals. Shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. Both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low...

journal_title：Life sciences

authors： Geetha RK,Vasudevan DM

更新日期：2004-11-19 00:00:00

abstract：:The conversion of beta-carotene to retinal and the succeeding metabolic process of the retinal leading to production of retinol and retinyl esters are the prerequisite for the utilization of beta-carotene as a provitamin A. These processes are participated by beta-carotene cleavage enzyme, retinal reductase and retino...

journal_title：Life sciences

authors： Tajima S,Goda T,Takase S

更新日期：1999-01-01 00:00:00

abstract：AIMS:In this study, we investigated the combined effect of Neurotropin® and pregabalin for L5-spinal nerve ligation (L5-SNL) model in rats and thiopental-induced sleep in mice. MAIN METHODS:The left fifth lumbar nerve of rats was tightly ligated with silk sutures under pentobarbital anesthesia. The hindpaw withdrawal ...

journal_title：Life sciences

authors： Okazaki R,Namba H,Yoshida H,Okai H,Taguchi K,Kawamura M

更新日期：2013-03-12 00:00:00

abstract：:An enzyme partially purified from bovine lung membranes appears to be endothelin converting enzyme (ECE). This enzyme specifically cleaves big endothelin-1 (big ET-1) at the proper site, between Trp21 and Val22, with maximum activity at pH 7.5 and with a Km of roughly 3 microM, to produce endothelin-1 (ET-1) and C-ter...

journal_title：Life sciences

authors： Kundu GC,Wilson IB

更新日期：1992-01-01 00:00:00

abstract：:Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone re...

journal_title：Life sciences

authors： Porreca F,Dray A

更新日期：1984-06-25 00:00:00

abstract：:Lymphocyte apoptosis occurs in response to stressors such as thermal injury, trauma, sepsis, and surgery. This study evaluated the effect of a single bout of physical exercise stress on the induction of apoptosis in murine thymocytes and splenic lymphocytes. Female C57BL/6 mice, treadmill exercised at a submaximal int...

journal_title：Life sciences

authors： Hoffman-Goetz L,Zajchowski S,Aldred A

更新日期：1999-01-01 00:00:00

abstract：:Castration increases the central nervous system (CNS) sensitivity to hexobarbital as measured by an EEG-threshold method. Testosterone treatment in doses from 1 to 5 mg/kg/day decreases CNS-sensitivity and restores threshold values in castrated rats to a level found in normal young adult male rats. ...

journal_title：Life sciences

authors： Bolander HG,Kourtopoulos H

更新日期：1985-03-11 00:00:00

abstract：:The ontogeny and regulation by isoproterenol of type II thyroxine 5'-deiodinase, N-acetyltransferase, and hydroxyindole-O-methyltransferase activities were studied in the rat Harderian gland. Both 5'-deiodinase and N-acetyltransferase activities exhibited maximal values at the first week of age. These activities gradu...

journal_title：Life sciences

authors： Osuna C,Rubio A,Goberna R,Guerrero JM

更新日期：1990-01-01 00:00:00

abstract：:Hypoxic preconditioning (HPC) has been well demonstrated to have potent protective effects in many cell types; however, the mechanisms responsible for this phenomenon are not fully understood. Recently, glucose-regulated protein 78 (GRP78), an inducible molecular chaperon, was indicated to be associated with ischemic ...

journal_title：Life sciences

authors： Pan YX,Ren AJ,Zheng J,Rong WF,Chen H,Yan XH,Wu C,Yuan WJ,Lin L

更新日期：2007-09-08 00:00:00

abstract：:Deficiencies in cellular cyclic AMP (cAMP) and nitric oxide (NO) production are thought to be involved in the pathogenesis of diabetic neuropathy. We used a human neuroblastoma cell line, SH-SY5Y, to investigate the effect of cilostazol, a specific cAMP phosphodiesterase inhibitor, on NO production and Na+, K+-ATPase ...

journal_title：Life sciences

authors： Inada H,Shindo H,Tawata M,Onaya T

更新日期：1999-01-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1) is a 76-amino-acid chemokine thought to be the major chemotactic factor for monocytes. MCP-1 is found in macrophage-rich areas of atherosclerotic lesions. Recent report indicates that MCP-1 is induced by glucose-stimulation, raising the important link between diabetes mellitu...

journal_title：Life sciences

authors： Murao K,Yu X,Cao WM,Imachi H,Chen K,Muraoka T,Kitanaka N,Li J,Ahmed RA,Matsumoto K,Nishiuchi T,Tokuda M,Ishida T

更新日期：2007-07-26 00:00:00

abstract：:CYP2J2 is one of the cytochrome P450 epoxygenases involved in the metabolism of arachidonic acid. CYP2J2 has been identified in several tissues, especially cardiovascular tissues. CYP2J2 has cardiovascular effects, as epoxyeicosatrienoic acid, one of its metabolites, has anti-inflammatory and vasodilative activities. ...

journal_title：Life sciences

authors： Nakayama K,Nitto T,Inoue T,Node K

更新日期：2008-08-29 00:00:00

abstract：AIMS:Lung cancer represents as the most prevalent tumor globally, among which non-small cell lung cancer (NSCLC) takes up for more than 80%. Lysine demethylase 4A (KDM4A) was dysregulated in NSCLC, but its role on the tumorigenesis in NSCLC cells and the mechanisms of actions are unclear. In this work, we evaluated its...

journal_title：Life sciences

authors： Sun S,Yang F,Zhu Y,Zhang S

更新日期：2020-12-01 00:00:00

abstract：:The cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. The present study examined the effects of scopolamine, a muscarinic cholinergic antagonist, on the development of behavioral sensitization to methamphetamine (MA). Rats treated with MA (1 mg/kg, s...

journal_title：Life sciences

authors： Ohmori T,Abekawa T,Koyama T

更新日期：1995-01-01 00:00:00

abstract：:The existence of a new factor (AF) in mice acting synergistically with known proaggregatory stimuli has been suggested by the present study in the plasma of mice challenged with intravenous collagen and adrenaline. Indomethacin, nordihydroguaretic acid (NDGA), BW 755C, phentolamine, cimetidine and ketanserin could not...

journal_title：Life sciences

authors： Dikshit M,Srimal RC

更新日期：1990-01-01 00:00:00

abstract：:The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...

journal_title：Life sciences

authors： Pertwee RG

更新日期：1999-01-01 00:00:00

abstract：:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visu...

journal_title：Life sciences

authors： Olgiati V,Quirion R,Bowen WD,Pert CB

更新日期：1982-10-18 00:00:00

abstract：:YM-09151-2(cis-N-(1-benzyl-2-methylpyrrolidin-3-yl) -5-chloro-2-methoxy-4-methylaminobenzamide) is a new benzamide which has been reported to be an antagonist of dopamine (DA) at D1-type DA receptors. In the present study, we have examined the extent of the interaction of YM-09151-2 with D2-type DA receptors in the an...

journal_title：Life sciences

authors： Meltzer HY,Mikuni M,Simonovic M,Gudelsky GA

更新日期：1983-02-28 00:00:00

abstract：AIMS:Acetylcholine (ACh) has been shown to increase ion and water excretion in the kidneys, resulting in hypotension. However, no evidence of renal parasympathetic innervation has been shown, and the source of ACh acting on nephrons is still unknown. The aim of the present study was to identify ACh-producing cells in t...

journal_title：Life sciences

authors： Maeda S,Jun JG,Kuwahara-Otani S,Tanaka K,Hayakawa T,Seki M

更新日期：2011-09-12 00:00:00

abstract：:Mechanisms by which opiates alter neuronal functions, including neuroendocrine functions, are not well defined. We have previously demonstrated that morphine rapidly and transiently increases expression of the proto-oncogene c-fos in the rat caudate-putamen. This regulation of the c-fos gene by morphine may represent ...

journal_title：Life sciences

authors： Chang SL,Harlan RE

更新日期：1990-01-01 00:00:00

abstract：:Methotrexate was found to stimulate asparagine synthetase activity in vivo by approximately six-fold in rat liver. The maximum effect of methotrexate on hepatic asparagine synthetase activity was observed sixteen hours after intraperitoneal injection of the drug. Cycloheximide, like methotrexate, is a protein synthesi...

journal_title：Life sciences

authors： Maul DM,Schuster SM

更新日期：1982-03-22 00:00:00

abstract：AIMS:We explored the effect of aerobic exercise on renal sinus adipose (RSA) accumulation and RSA accumulation-related renal injury in obese mice. MAIN METHODS:C57BL/6J male mice (n = 30) were evenly divided into three groups: control group (CON, n = 10), obese group (OB, n = 10; given high-fat diet) and obese + aerob...

journal_title：Life sciences

authors： Wang SS,Gu Q,Liu N,Li J,Liu X

更新日期：2021-01-23 00:00:00

abstract：:The beta adrenoceptor antagonist radioligand [3H] dihydroalprenolol (DHA) has been used to characterise beta adrenoceptors in membranes prepared from rat renal glomeruli. Association of the ligand was rapid and had reached equilibrium within 10 mins at 37 degrees C. Dissociation occurred in two distinct phases, a rapi...

journal_title：Life sciences

authors： McPherson GA,Summers RJ

更新日期：1983-07-04 00:00:00

abstract：:Retinoic acids and their cognate nuclear receptors exert a substantial regulatory role in cell growth and development as well as in the neuroendocrine system. These effects are primarily mediated by all-trans retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor superfamily of ligand inducibl...

journal_title：Life sciences

authors： Brtko J,Knopp J,Kvetnanský R

更新日期：2000-03-24 00:00:00

abstract：AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible u...

journal_title：Life sciences

authors： Sahu BD,Kumar JM,Kuncha M,Borkar RM,Srinivas R,Sistla R

更新日期：2016-01-01 00:00:00

abstract：AIMS:To determine whether ginsenoside Rg1 is involved in scratch wound healing through altered expression of related molecules in astrocytes and improved functional recovery after spinal cord injury (SCI). MATERIALS AND METHODS:Astrocytes were isolated from rats, followed by Rg1 treatment. The wound healing test was p...

journal_title：Life sciences

authors： Xu L,Tang YY,Ben XL,Cheng MH,Guo WX,Liu Y,Lu ZF,Deng JL

更新日期：2020-07-01 00:00:00

abstract：AIMS:Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and inward rectifi...

journal_title：Life sciences

authors： Li W,Dong M,Guo P,Liu Y,Jing Y,Chen R,Zhang M

更新日期：2019-03-15 00:00:00

abstract：:The aims of this study were to determine whether endothelin-1 (ET-1), a positive inotropic agent, altered the production of cyclic AMP (cAMP) in adult feline cardiac myocytes and to characterize the effect with respect to G-protein-coupling and calcium regulation of adenylyl cyclase. ET-1 inhibited basal and/or stimul...

journal_title：Life sciences

authors： Jones LG

更新日期：1996-01-01 00:00:00