Abstract：
:Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone reversible inhibition of the micturition reflex. Cross-tolerance was demonstrated between motilin and morphine in this respect. These data suggest a physiological role for motilin within CNS to alter urinary bladder motility, possibly through an enkephalinergic or naloxone-sensitive link.
journal_name
Life Scijournal_title
Life sciencesauthors
Porreca F,Dray Adoi
10.1016/0024-3205(84)90043-2subject
Has Abstractpub_date
1984-06-25 00:00:00pages
2577-81issue
26eissn
0024-3205issn
1879-0631pii
0024-3205(84)90043-2journal_volume
34pub_type
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