Abstract：
:Endothelin is a vasoconstrictor peptide which has recently been isolated and sequenced from the vascular endothelial cells. It was reported to increase blood pressure in vivo and produce a prolonged contraction with a slow onset in vitro. The purpose of this study was to investigate whether endothelin can lower the portal pressure as another endogenous vasoconstriction peptidevasopressin (AVP) can. Heart rate, systemic blood pressure, portal pressure, and portal vein blood flow were measured. Effects of endothelin on these parameters were compared with those of AVP. Endothelin 10(-10) mol/Kg significantly decreased all of the parameters mentioned. At the higher dose (5 x 10(-10) mol/Kg), however, the portal pressure and blood pressure were increased and portal vein blood flow was unchanged. On the other hand, AVP decreased the portal pressure and portal vein blood flow but elevated the systemic blood pressure. In vitro experiments revealed that endothelin contracted both tail artery and portal vein of rat and vasopressin contracted only tail artery. We concluded that although both are endogenous vasoconstricting peptides, endothelin and AVP affect differently on arterial and venous vascular beds as well as on portal pressure.
journal_name
Life Scijournal_title
Life sciencesauthors
Yang MC,Yu PC,Tu MS,Lay CS,Hong CY,Chou CK,Chen CF,Kuo JSdoi
10.1016/0024-3205(90)90508-osubject
Has Abstractpub_date
1990-01-01 00:00:00pages
1929-36issue
26eissn
0024-3205issn
1879-0631pii
0024-3205(90)90508-Ojournal_volume
46pub_type
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