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Comparison of the effects of amino acid mixture and placebo on plasma tryptophan to large neutral amino acid ratio.

Abstract：

:To assess the possible role of altered central serotonin function in psychiatric disorders, investigators have utilized pharmacological challenge testing with an amino acid mixture to decrease blood tryptophan concentration and, indirectly, brain serotonin levels. The aim of this pilot study was to assess the effectiveness of a modified amino mixture, administered in capsule form, in decreasing plasma tryptophan levels. Studies were conducted in six healthy, medication-free female volunteers. Following double-blind, randomized, cross-over design, subjects received on separate days capsules containing a tryptophan-free amino acid mixture (31.5 grams) or lactose placebo. Over the six hours following amino acid administration, plasma tryptophan concentrations decreased to 21% of baseline values, while the tryptophan/large neutral amino acid ratio decreased to 6% of baseline. Subjects reported minimal symptoms of nausea or other side effects following amino acid administration. The results suggest that the modified amino acid mixture may be useful in assessing behavioral responses to acute tryptophan depletion challenge testing.

journal_name

Life Sci

journal_title

Life sciences

authors

Wolfe BE,Metzger ED,Jimerson DC

doi

10.1016/0024-3205(95)00103-4

subject

Has Abstract

pub_date

1995-03-17 00:00:00

pages

1395-400

issue

17

eissn

0024-3205

issn

1879-0631

pii

0024320595001034

journal_volume

56

pub_type

临床试验,杂志文章,随机对照试验

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