Abstract：
:There is an augmented platelet intracellular calcium response to serotonin stimulation in major depression. The role that calcium influx has in this process is not known. The objective of this study was to determine platelet calcium influx in response to serotonin by two methods, Mn2+ influx and 45Ca2+ uptake, in order to observe if the uptake response to serotonin was augmented in major depression by comparing the response to normal controls. The use of the two methods of calcium influx showed that serotonin stimulates calcium uptake into platelets. Furthermore, patients with major depression have significantly augmented platelet calcium uptake in response to serotonin. The interesting finding was that calcium uptake into platelets is biphasic, occurring immediately and after five minutes. These results may support the two pool model for calcium oscillations within cells whereby extracellular calcium is needed for intracellular calcium release, and for replenishment of depleted stores once intracellular calcium is released.
journal_name
Life Scijournal_title
Life sciencesauthors
Plein H,Berk M,Eppel S,Butkow Ndoi
10.1016/s0024-3205(99)00608-6subject
Has Abstractpub_date
2000-01-01 00:00:00pages
425-31issue
5eissn
0024-3205issn
1879-0631pii
S0024320599006086journal_volume
66pub_type
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