Endogenous opioids, circadian rhythms, nutrient deprivation, eating and drinking.

Abstract:

:Immunoreactive (ir) beta-endorphin (b-END) and dynorphin (DYN) in rat brain and pituitary were measured after food and water deprivation and from brains taken during either day or night. In other rats, eating and drinking were measured following lesions in the arcuate n. Ir-DYN levels are higher in hypothalamus and lower in pituitary at night. Deprivation, particularly water deprivation, increases hypothalamic, day-time ir-DYN. Water deprivation decreases pituitary levels of ir-DYN. Arcuate-lesions, depleting both ir-b-END and ir-DYN, do not modify total daily intake of water or food but does modify circadian rhythmicity of eating and drinking. These data support the conclusion that b-END and DYN are involved in maintaining day-night patterns of eating and drinking.

journal_name

Life Sci

journal_title

Life sciences

authors

Reid LD,Konecka AM,Przewłocki R,Millan MH,Millan MJ,Herz A

doi

10.1016/0024-3205(82)90221-1

subject

Has Abstract

pub_date

1982-10-18 00:00:00

pages

1829-32

issue

16-17

eissn

0024-3205

issn

1879-0631

pii

0024-3205(82)90221-1

journal_volume

31

pub_type

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