当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Scopolamine prevents the development of sensitization to methamphetamine.

Scopolamine prevents the development of sensitization to methamphetamine.

Abstract：

:The cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. The present study examined the effects of scopolamine, a muscarinic cholinergic antagonist, on the development of behavioral sensitization to methamphetamine (MA). Rats treated with MA (1 mg/kg, sc) for 10 days indicated significantly enhanced motor activity when tested with MA (0.5 mg/kg) after a 7-8 day withdrawal, indicating the development of behavioral sensitization. Pretreatment with scopolamine (3 mg/kg) prior to MA administration prevented the development of the phenomenon. Rats treated with scopolamine alone showed no difference in the motor activity compared to those treated with saline. These results suggest that stimulation of muscarinic cholinergic receptors plays a role in the development of behavioral sensitization.

journal_name

Life Sci

journal_title

Life sciences

authors

Ohmori T,Abekawa T,Koyama T

doi

10.1016/0024-3205(95)00062-b

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

1223-9

issue

14

eissn

0024-3205

issn

1879-0631

pii

002432059500062B

journal_volume

56

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Treatment with polyamines can prevent monosodium glutamate neurotoxicity in the rat retina.

    abstract：:It has been previously shown that treatment of newborn rats with the polyamines putrescine, spermidine and spermine can rescue sympathetic neurons from naturally occurring cell death and from induced death after axotomy or immunosympathectomy. The present study demonstrates that polyamine treatment can also prevent th...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90409-8

    authors： Gilad GM,Gilad VH

    更新日期：1989-01-01 00:00:00

  • Protein glycation: effects upon protein recognition by the proximal tubule.

    abstract：:Reabsorption of 125I labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different exp...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90335-m

    authors： Kowluru A,Kowluru RA,Solomon S,Martinez L

    更新日期：1992-01-01 00:00:00

  • Agmatine attenuates intestinal ischemia and reperfusion injury by reducing oxidative stress and inflammatory reaction in rats.

    abstract：AIMS:Oxidative stress and inflammatory response are major factors causing several tissue injuries in intestinal ischemia and reperfusion (I/R). Agmatine has been reported to attenuate I/R injury of various organs. The present study aims to analyze the possible protective effects of agmatine on intestinal I/R injury in ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.08.032

    authors： Turan I,Ozacmak HS,Ozacmak VH,Barut F,Araslı M

    更新日期：2017-11-15 00:00:00

  • Ruthenium red-sensitive cation channels, but not calcitonin gene-related peptide or substance P-mediated mechanisms, protect duodenal villi against acid-induced damage.

    abstract：:Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the protective mesenteric hyperemia after intraduodenal acidification. Mechanisms associated the sensory neuropeptides, e.g. calcitonin gene-related peptide (CGRP), substance P, and ruthenium red-sensitive cation channels contribute to acid-induc...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)02106-9

    authors： Leung FW,Iwata F,Kao J,Seno K,Itoh M,Leung JW

    更新日期：2002-10-18 00:00:00

  • NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in mice.

    abstract：:The purpose of this study was to characterize behavioral interactions between glutamatergic and serotonergic 5-HT2 receptors. Both competitive (AP-5 [D-2-amino-5-phosphovalerate] and D-CPP [3-(2carboxypiperazine-4yl)-propylphosphonate]) and noncompetitive (MK-801 [dizocilpine], ketamine, dextrorphan and dextromethorph...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00519-0

    authors： Kim HS,Park IS,Park WK

    更新日期：1998-01-01 00:00:00

  • The antidepressant effects of rosiglitazone on rats with depression induced by neuropathic pain.

    abstract：:A growing number of studies reported that rosiglitazone (a PPARgamma agonist) could ameliorate the painful state and prevent stress-induced depression. However, whether rosiglitazone can prevent pain-induced depression is unclear. This study aimed to explore the antidepressant effects of rosiglitazone in L5 spinal ner...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.04.057

    authors： Zong J,Liao X,Ren B,Wang Z

    更新日期：2018-06-15 00:00:00

  • Pituitary adenylate cyclase activating polypeptide (PACAP) potently enhances tyrosine hydroxylase (TH) expression in adrenal chromaffin cells.

    abstract：:In primary cultured bovine adrenal chromaffin cells (BACC), pituitary adenylate cyclase activating polypeptide 1-38 (PACAP) produced a dose related increase in tyrosine hydroxylase (TH) Vmax when measured 48 hours after the beginning of the treatment; a significant increase was observed with 0.5 nM and the maximal ind...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00614-8

    authors： Rius RA,Guidotti A,Costa E

    更新日期：1994-01-01 00:00:00

  • Evaluation of tissue ascorbic acid status in different hormonal states of female rat.

    abstract：:The distribution pattern of ascorbic acid in the endocrine organs and/or tissues was investigated during various sexual states of female rats to demonstrate a correlation between ascorbic acid concentration and sex hormone activity. The concentration of ascorbic acid was estimated in the plasma, liver, pancreas, thyro...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90111-f

    authors： Das PC,Das KP,Bagchi K,Dey CD

    更新日期：1993-01-01 00:00:00

  • GPER agonist dilates mesenteric arteries via PI3K-Akt-eNOS and potassium channels in both sexes.

    abstract：AIM:The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.06.020

    authors： Peixoto P,Aires RD,Lemos VS,Bissoli NS,Santos RLD

    更新日期：2017-08-15 00:00:00

  • In vitro interaction of premazepam with benzodiazepine receptors in rat brain regions.

    abstract：:Premazepam (PRZ) in vitro competitively displaced 3H-diazepam (DIA), 3H-flunitrazepam (FLU) and 3H-RO 15-1788 from their binding sites on rat brain synaptosomes, with a potency intermediate to other benzodiazepines (BDZs), and Hill coefficients near 1 in different brain regions. Incubation at 37 degrees C reduced prem...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90646-5

    authors： Barone D,Colombo G,Glasser A,Luzzani F,Mennini T

    更新日期：1984-07-23 00:00:00

  • Proteomics analysis of the actions of grape seed extract in rat brain: technological and biological implications for the study of the actions of psychoactive compounds.

    abstract：:Grape seed extract (GSE) is a commonly available dietary supplement taken for the anti-oxidant activity that's attributed to its proanthocyanidin (oligomers of monomeric polyphenols) content. Similar polyphenol-enriched preparations from blueberries and soy have shown protection against ovariectomy-induced or age-rela...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.12.008

    authors： Kim H,Deshane J,Barnes S,Meleth S

    更新日期：2006-03-27 00:00:00

  • Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice.

    abstract：AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible u...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.11.018

    authors： Sahu BD,Kumar JM,Kuncha M,Borkar RM,Srinivas R,Sistla R

    更新日期：2016-01-01 00:00:00

  • Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats: Role of PI3K-Akt-eNOS pathway.

    abstract：OBJECTIVE:A deficiency in hydrogen sulfide (H2S) and nitric oxide (NO) contributes to the development of type 2 diabetes (T2D). An inhibitory effect on liver gluconeogenesis has been reported in rats with T2D with co-administration of sodium nitrite and sodium hydrosulfide (NaSH); the underlying mechanisms have however...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118770

    authors： Jeddi S,Gheibi S,Carlström M,Kashfi K,Ghasemi A

    更新日期：2021-01-15 00:00:00

  • Synergistic interaction between alpha- and beta-adrenergic receptors in rat brain slices: possible site for antidepressant drug action.

    abstract：:Experiments were undertaken to examine the characteristics of the adrenergic receptor-coupled cAMP system in rat brain slices. It was found that the potentiation of isoproterenol-stimulated cAMP accumulation by 6-fluoronorepinephrine, an alpha-adrenergic agonist, is largely dependent upon the degree of beta-receptor o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90129-8

    authors： Pilc A,Enna SJ

    更新日期：1985-09-30 00:00:00

  • Hypoxic preconditioning enhances cell hypoxia tolerance and correlated lncRNA and mRNA analysis.

    abstract：AIMS:Hypoxia makes cells death but it is not always true. Short term anoxia can boost remaining cells activities and promote tissue repair. This study is to explore the effects of hypoxic preconditioning (HP) on osteoblasts and analyze the involved lncRNA and mRNA. MAIN METHODS:Human osteoblast was used. Normoxic cont...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.07.014

    authors： Wang D,Liu Y,Yang X,Zhou J

    更新日期：2018-09-01 00:00:00

  • Evidence that endogenous 6-(ARG or LYS)-opioid peptides can interact with kappa-receptors as agonists.

    abstract：:Evidence is provided for the abilities of endogenous 6-(Arg or Lys)-opioid peptides to interact with kappa-receptors as agonists. Dynorphin-(1-17) and -(1-8), alpha- and beta-neo-endorphin, [Met5]-enkephalin-Arg6-Phe7 and des acetyl salmon endorphin I significantly inhibited the electrically-evoked contractions of rab...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90191-6

    authors： Oka T,Negishi K

    更新日期：1982-10-18 00:00:00

  • Effects of dopamine metabolites on locomotor activities and on the binding of dopamine: relevance to the side effects of L-dopa.

    abstract：:L-dopa is the major treatment for Parkinson's disease (PD), but its efficacy is limited by the presence of dyskinesia. The dyskinesia develops over a period of exposure to L-dopa and is related to the dosage, therefore, the cause may involve inductive changes that produce toxic levels of metabolites, interfering with ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00543-9

    authors： Charlton CG,Crowell B Jr

    更新日期：2000-04-21 00:00:00

  • Recent developments in the understanding of bradykinin receptors.

    abstract：:The dramatic activities of bradykinin and related peptides as mediators of pain, inflammation and hypotension have been intensely studied for several decades. More recently, the involvement of bradykinin in regulation of ion transport by epithelia, hormone release from endocrine organs, energy metabolism, tissue growt...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(92)90201-y

    authors： Burch RM,Kyle DJ

    更新日期：1992-01-01 00:00:00

  • The patterns of prolactin release by ECT and TRH compared.

    abstract：:The patterns of prolactin release after bilateral ECT and after 0.4 mg TRH i.v. were studied in 11 female melancholic patients in a 5-min sampling protocol. Mean prolactin peaking times were 10.2 min after ECT and 20.5 min after TRH. The elimination rate coefficients were significantly lower--and the corresponding hal...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90206-2

    authors： Markianos M,Papakostas Y,Stefanis C

    更新日期：1987-09-07 00:00:00

  • CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4.

    abstract：HEADING AIMS:Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdomi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117533

    authors： Yue J,Zhu T,Yang J,Si Y,Xu X,Fang Y,Fu W

    更新日期：2020-07-15 00:00:00

  • Effect of repeated allogeneic bone marrow mononuclear cell transplantation on brain injury following transient focal cerebral ischemia in rats.

    abstract：AIMS:Transplantation of bone marrow mononuclear cells (BMMCs) exerts neuroprotection against cerebral ischemia. We examined the therapeutic timepoint of allogeneic BMMC transplantation in a rat model of focal cerebral ischemia, and determined the effects of repeated transplantation outside the therapeutic window. MAIN...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2013.12.016

    authors： Kamiya F,Ueda M,Nito C,Kamiya N,Inaba T,Suda S,Saito T,Muraga K,Katayama Y

    更新日期：2014-01-24 00:00:00

  • High affinity peptide histidine isoleucine-preferring receptors in rat liver.

    abstract：:Peptide Histidine Isoleucine (PHI) is generally considered a low affinity agonist for Vasoactive Intestinal Peptide (VIP) receptors. In this study, we investigated the presence and characteristics of [125I]PHI binding sites on rat liver membranes. Detergents at nonsolubilizing concentrations (1 mM CHAPS or 0.01% Tween...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90661-8

    authors： Paul S,Chou J,Kubota E

    更新日期：1987-11-23 00:00:00

  • Ontogeny of endothelin and its receptors in rat brain.

    abstract：:The ontogeny of endothelin (ET) system in rats was studied in preterm (18 days of gestation), term (21 days of gestation) and 1 week post term rats. Brains were dissected out and (1) processed for the estimation of endogenous ET-1 by RIA and (2) membranes were prepared for radioreceptor binding. Receptor characteristi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90300-e

    authors： Gulati A,Rebello S,Chari G,Bhat R

    更新日期：1992-01-01 00:00:00

  • D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs.

    abstract：:Monocyte chemoattractant protein-1 (MCP-1) is a 76-amino-acid chemokine thought to be the major chemotactic factor for monocytes. MCP-1 is found in macrophage-rich areas of atherosclerotic lesions. Recent report indicates that MCP-1 is induced by glucose-stimulation, raising the important link between diabetes mellitu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.06.019

    authors： Murao K,Yu X,Cao WM,Imachi H,Chen K,Muraoka T,Kitanaka N,Li J,Ahmed RA,Matsumoto K,Nishiuchi T,Tokuda M,Ishida T

    更新日期：2007-07-26 00:00:00

  • Effect of taurine on cholesterol metabolism in hamsters: up-regulation of low density lipoprotein (LDL) receptor by taurine.

    abstract：:The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)01507-2

    authors： Murakami S,Kondo Y,Toda Y,Kitajima H,Kameo K,Sakono M,Fukuda N

    更新日期：2002-04-05 00:00:00

  • Comparative ability of chicken and mammalian LHRH to release LH from rooster pituitary cells in vitro.

    abstract：:Biological properties of homogeneous solutions of chicken (c) and mammalian (m) LHRH were compared by their ability to release LH, in vitro, from a rooster pituitary cell incubation system. Homogeneity of the two LHRH species was confirmed by High Performance Liquid Chromatography (HPLC) using linear gradients of acet...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90678-7

    authors： Johnson AL,Dickerman RW,Advis JP

    更新日期：1984-05-07 00:00:00

  • Interleukin-18 induces serum amyloid A (SAA) protein production from rheumatoid synovial fibroblasts.

    abstract：:Interleukin-18 (IL-18) is a novel proinflammatory cytokine that was recently found in synovial fluids and synovial tissues from patients with rheumatoid arthritis (RA). To investigate the role of IL-18 in rheumatoid synovitis, the levels of IL-18 and serum amyloid A (SAA) were measured in synovial fluids from 24 patie...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2003.08.025

    authors： Tanaka F,Migita K,Kawabe Y,Aoyagi T,Ida H,Kawakami A,Eguchi K

    更新日期：2004-02-13 00:00:00

  • Functional role of M2 muscarinic receptors in the guinea pig ileum.

    abstract：:Muscarinic agonists elicit contraction in the standard guinea pig ileum bioassay through activation of M3 muscarinic receptors that are also linked to phosphoinositide hydrolysis. Surprisingly, the most abundant muscarinic receptor in the ileum is the M2 which causes a specific inhibition of cyclic AMP accumulation el...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(94)00035-q

    authors： Ehlert FJ,Thomas EA

    更新日期：1995-01-01 00:00:00

  • The role of non-critical binding proteins in the sensitivity of acetylcholinesterase from different species to diisopropyl fluorophosphate (DFP), in vitro.

    abstract：:In vitro studies showed that organophosphate insecticides have different IC50 values (i.e., concentration of inhibitor required to inhibit 50% enzyme activity) for acetylcholinesterases (AChE's) from different species. Since previous reports indicated that the binding of active cholinesterase inhibitors to non-critica...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90426-x

    authors： Wang C,Murphy SD

    更新日期：1982-07-12 00:00:00

  • Cardioprotective effects of baicalein on heart failure via modulation of Ca(2+) handling proteins in vivo and in vitro.

    abstract：AIMS:Baicalein is a widely used Chinese herbal medicine extracted from Labiatae plants Scutellaria baicalensis Georgi's dry root, which has multiple pharmacological activities. However, the precise mechanism of baicalein against myocardial remodeling remains poorly understood. The aim of our study was to investigate th...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2015.12.036

    authors： Zhao F,Fu L,Yang W,Dong Y,Yang J,Sun S,Hou Y

    更新日期：2016-01-15 00:00:00