Effect of taurine on cholesterol metabolism in hamsters: up-regulation of low density lipoprotein (LDL) receptor by taurine.

abstract：AIM:Diabetic nephropathy is the leading cause of end stage renal disease in developed countries throughout the world. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system is the main problem that is responsible for the progression of diabetic kidney disease. In this s...

journal_title：Life sciences

authors： Kuo CW,Shen CJ,Tung YT,Chen HL,Chen YH,Chang WH,Cheng KC,Yang SH,Chen CM

更新日期：2015-08-15 00:00:00

abstract：:The aim of this study was to assess the anxiolytic effect of berberine (abbrev. BER) using two experimental anxiety models in the mouse. In the black and white test of anxiety, berberine (100, 500 mg/kg) produced an increase in the first time entry, time spent in the white section, and total changes between two compar...

journal_title：Life sciences

authors： Peng WH,Wu CR,Chen CS,Chen CF,Leu ZC,Hsieh MT

更新日期：2004-10-01 00:00:00

abstract：:Two breeds of rats, Charles River Wistar [Crl(Wi)Br.] and HSD Wistar [Wistar per LATI (Budapest) Br.], with remarkable difference in learning performance were selected. The rats were trained in the shuttle box with 100 trials per day and the number of conditioned avoidance responses (CARs), the escape failures (EFs) t...

journal_title：Life sciences

authors： Knoll J,Knoll B,Miklya I

更新日期：1996-01-01 00:00:00

abstract：AIMS:Naturally-derived farnesol has been reported for its chemopreventive and chemotherapeutic efficacy in various cancers. However, the mechanism of action of farnesol is still to be elucidated. The present study demonstrates the chemopreventive potential of farnesol on 9,10-dimethylbenz(a)anthracene (DMBA)-initiated ...

journal_title：Life sciences

authors： Chaudhary SC,Alam MS,Siddiqui MS,Athar M

更新日期：2009-07-31 00:00:00

abstract：:Propentofylline (PPF) is a xanthine derivative with pharmacological effects that are distinct from those of classic methylxanthines. It depresses the activation of microglial cells and astrocytes, which is associated with neuronal damage during neural inflammation and hypoxia. Our previous studies showed that PPF impr...

journal_title：Life sciences

authors： Martins-Júnior JL,Bernardi MM,Bondan EF

更新日期：2016-03-01 00:00:00

abstract：:Adenylate cyclase activity in pancreatic acinar cell membranes was determined in rats that had undergone a treatment with pentagastrin (250 micrograms/kg, intraperitoneal three times daily) for 1 week or that had undergone small bowel resection (90%) and were sacrified at 2 weeks, 1 month and 6 months after interventi...

journal_title：Life sciences

authors： Alvaro-Alonso I,Boyano-Adánez MC,Martín-Espinosa A,Arilla E

更新日期：1995-01-01 00:00:00

abstract：AIMS:Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids. To date, preclinical studies have only examined the eff...

journal_title：Life sciences

authors： Lacy RT,Strickland JC,Brophy MK,Witte MA,Smith MA

更新日期：2014-10-02 00:00:00

abstract：:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten. We have recently shown that GE-B5 stimulates prolactin (PRL) secretion in rats; this effect is abolished by preadministration of the opioid receptor antagonist naloxone. However, since the structure of naloxone allows it...

journal_title：Life sciences

authors： Fanciulli G,Dettori A,Demontis MP,Tomasi PA,Anania V,Delitala G

更新日期：2005-02-25 00:00:00

abstract：AIMS:Endoplasmic reticulum stress (ERS) as an emerging factor is involved in insulin resistance (IR), which is the pathological basis of diabetes mellitus. Accumulation of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase is associated with IR, but the underlying mechanisms have not b...

journal_title：Life sciences

authors： Qiu N,Wei XM,Zhang ZJ,He YL,Zhou XK,Xiong Y

更新日期：2020-11-01 00:00:00

abstract：:Histamine is a biogenic amine that plays an essential role in controlling many physiological functions, both in the central nervous system (CNS) and the peripheral nervous system (PNS). Most of these physiological effects are mediated through interactions with four histamine receptor subtypes, all of which are members...

journal_title：Life sciences

authors： Micallef S,Stark H,Sasse A

更新日期：2013-10-10 00:00:00

abstract：AIMS:Ischemia/reperfusion injury (IRI), resulting from hypoxic damage within a graft, is the leading cause of cell death and graft rejection. In this study, we investigated whether a HIF-1α inhibitor or various antioxidants were able to prevent ischemic injury in a cellular model in which experimental hypoxia was induc...

journal_title：Life sciences

authors： Song H,Han IY,Kim Y,Kim YH,Choi IW,Seo SK,Jung SY,Park S,Kang MS

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...

journal_title：Life sciences

authors： Hossein-Khannazer N,Hashemi SM,Namaki S,Ghanbarian H,Sattari M,Khojasteh A

更新日期：2019-01-01 00:00:00

abstract：AIMS:We investigated the pathophysiological changes in mice lacking α2-antiplasmin (α2-AP) and plasminogen activator inhibitor type-1 (PAI-1) genes, and elucidated the involvement of these inhibitors for fibrinolysis in immune response. MAIN METHODS:The pathophysiological changes induced by a lack of both α2-AP and PA...

journal_title：Life sciences

authors： Okada K,Ueshima S,Kawao N,Yano M,Tamura Y,Tanaka M,Sakamoto A,Hatano M,Arima M,Miyata S,Nagai N,Tokuhisa T,Matsuo O

更新日期：2013-07-30 00:00:00

abstract：AIM:Renin-angiotensin system has a role in inflammation and also involves in learning and memory. In the present study, the effects of captopril on lipopolysaccharide (LPS) induced learning and memory impairments, hippocampal cytokine levels and brain tissues oxidative damage was investigated. MATERIALS AND METHODS:Th...

journal_title：Life sciences

authors： Abareshi A,Hosseini M,Beheshti F,Norouzi F,Khazaei M,Sadeghnia HR,Boskabady MH,Shafei MN,Anaeigoudari A

更新日期：2016-12-15 00:00:00

abstract：:Calcium ionophores, such as the A23187, cause endothelium-dependent relaxation of arterial strips with intact endothelium, whereas the effect of the ionophore should result from the combination of a relaxation caused by the endothelium-dependent factors and of a contraction of the smooth muscles. In addition, the appl...

journal_title：Life sciences

authors： Budel S,Beny JL

更新日期：2000-06-23 00:00:00

abstract：:It is well known that the immune function can be compromised by stress. To investigate immune function in mice stressed by experimental restraint or unavoidable and opioid dependent stress, we evaluated the changes in total body weight and in organ weights (liver, spleen and thymus) of these animals, as well as the ph...

journal_title：Life sciences

authors： Teshima H,Sogawa H,Kihara H,Kubo C,Mori K,Nakagawa T

更新日期：1990-01-01 00:00:00

abstract：:This study examined the effects of chronic treatment of a new phosphodiesterase type 5 inhibitor, DA-8159, on endothelial dysfunction in stroke-prone spontaneously hypertensive rats (SHR-SP). Six-week-old male SHR-SP were divided into 4 groups; vehicle control, DA-8159 1, 3, and 10 mg/kg/day. During a 32-week experime...

journal_title：Life sciences

authors： Choi SM,Kim JE,Kang KK

更新日期：2006-02-09 00:00:00

abstract：:Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS). In the present study, the involvement of secondary signaling molecules in CYP1A1-mediated augmentation of iNOS expression in benzo(a)pyrene-t...

journal_title：Life sciences

authors： Kumar A,Upadhyay G,Modi DR,Singh MP

更新日期：2007-11-30 00:00:00

abstract：:Thermodynamic analysis of pharmacologic data potentially offers an insight into the molecular events underlying drug-receptor interactions not obtainable by other techniques. Embodied in thermodynamics are the laws governing the interconvertibility of heat and work and, hence, it is a particularly apt framework for th...

journal_title：Life sciences

authors： Raffa RB,Porreca F

更新日期：1989-01-01 00:00:00

abstract：:When s-triazolo[3,4-a]phthalazine (Tri-P) was orally administered in rats, a more lipophilic metabolite M-1 than the parent compound was isolated from the urine. The metabolite M-1 was identified as 7-methylthio Tri-P by means of high resolution MS and two-dimensional NMR spectrometry. Furthermore, the 7-methylthio co...

journal_title：Life sciences

authors： Imamura Y,Noda A,Imamura T,Ono Y,Okawara T,Noda H

更新日期：2003-11-21 00:00:00

abstract：:Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) we...

journal_title：Life sciences

authors： Berrettini WH,Nurnberger JI Jr,Gold PW,Chretien M,Chrousos GP,Chan JS,Goldin LR,Gershon ES

更新日期：1985-09-30 00:00:00

abstract：OBJECTIVE:To explore the correlation of the viscus fat area (VFA) with the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus (T2DM). METHODS:A total of 202 patients with T2DM were divided into two groups based on VFA (a VFA ≥ 100 cm2 group and a VFA < 100 cm2 group), or f...

journal_title：Life sciences

authors： Xu L,Song P,Xu J,Zhang H,Yu C,Guan Q,Zhao M,Zhang X

更新日期：2019-03-01 00:00:00

abstract：:The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of flavonols and their glycosides (FOHs), i.e., myricetin (MY), quercetin (Q), morin (MO), kaempferol (K), rutin (R), quercetin galactopyranosi...

journal_title：Life sciences

authors： Dai F,Miao Q,Zhou B,Yang L,Liu ZL

更新日期：2006-04-18 00:00:00

abstract：:Patients with neurogenic orthostatic hypotension due to multiple system atrophy (MSA) or pure autonomic failure (PAF) excrete lower amounts of homovanillic acid (HVA) than do normal subjects. There is a highly significant correlation between the rates of excretion of HVA and norepinephrine metabolites. The regression ...

journal_title：Life sciences

authors： Kopin IJ,Oliver JA,Polinsky RJ

更新日期：1988-01-01 00:00:00

abstract：:Hydroxyethyl starch (HES) found in rat serum and spleen after single and daily administrations of 0.9 g/kg for 1 week was characterized by gas-liquid chromatography. There was very little difference in the degree of substitution (D.S.) and molar substitution (M.S.) of HES in serum samples obtained at 1 hour and 57 day...

journal_title：Life sciences

authors： Sum CY,Lai CM,Yacobi A,Kalhorn TF

更新日期：1983-11-14 00:00:00

abstract：UNLABELLED:Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS:Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen to bind to nuclear receptors. MATERIALS AND METHODS:In silico screening predicted t...

journal_title：Life sciences

authors： Zloh M,Perez-Diaz N,Tang L,Patel P,Mackenzie LS

更新日期：2016-02-01 00:00:00

abstract：:This study was designed to evaluate the synergistic cytotoxicity of herb prescription, Palgin, in adriamycin-treated cancer cells. The combination of Palgin and adriamycin synergistically augmented the cytotoxicity of Chang and HL-60 cells, but not in Hep3B and Alexander cells. The cytotoxicity of two drugs was reveal...

journal_title：Life sciences

authors： Lim YS,So HS,Kim MS,Moon G,Won JH,Baek SW,Moon SR,Yang SH,Kim BJ,Ko CB,Park R

更新日期：2002-10-04 00:00:00

abstract：:The role of the autonomic nervous system in the modulation of the immune response to emotional stimuli, was established in rats subjected to the passive avoidance test. An increase in splenic primary antibody response directed against SRBC was found after exposure of rats to the passive avoidance apparatus (novelty). ...

journal_title：Life sciences

authors： Croiset G,Heijnen CJ,van der Wal WE,de Boer SF,de Wied D

更新日期：1990-01-01 00:00:00

abstract：:In order to further elucidate a possible role of neuropeptides and GABA in the pathogenesis of febrile convulsions, we studied changes of immunoreactive-arginine vasopressin (IR-AVP), IR-somatostatin (IR-SRIF) and gamma-aminobutyric acid (GABA) in the rat brain after febrile convulsions induced by ultra-red light (UR)...

journal_title：Life sciences

authors： Nagaki S,Nagaki S,Minatogawa Y,Sadamatsu M,Kato N,Osawa M,Fukuyama Y

更新日期：1996-01-01 00:00:00

abstract：AIMS:We tested the hypothesis that an in vivo gene delivery of the pro-survival protein XIAP (X-chromosome linked inhibitor of apoptosis protein) protects against myocardial apoptosis and infarction following ischemia/reperfusion. MAIN METHODS:Nineteen rabbits were chronically instrumented with a hydraulic occluder pl...

journal_title：Life sciences

authors： Kim SJ,Kuklov A,Crystal GJ

更新日期：2011-03-28 00:00:00