Abstract：
:The effects of aporphines and secoaporphines on glucose uptake by isolated intestinal brush-border membrane vesicles (BBMV) or basolateral membrane vesicles (BLMV) and glucose absorption during in situ intestinal perfusion were studied. Of the tested compounds, N-allylsecoboldine was the most potent glucose uptake inhibitor, with IC50 values of 159 microM and 121 microM, respectively, for uptake by BBMV and BLMV. While thaliporphine competitively inhibited glucose uptake by both membrane preparations, inhibition by N-allylsecoboldine was competitive using BBMV and noncompetitive using BLMV. In addition, N-allylsecoboldine significantly reduced both glucose absorption during in situ intestinal perfusion and blood glucose levels in the oral glucose tolerance test. The results demonstrate that levels of both aporphines and secoaporphines achievable by oral administration have an inhibitory effect on intestinal glucose uptake and suggest that the hypoglycemic effects of these compounds merit attention.
journal_name
Life Scijournal_title
Life sciencesauthors
Lin CJ,Chen CH,Liu FW,Kang JJ,Chen CK,Lee SL,Lee SSdoi
10.1016/j.lfs.2005.12.031subject
Has Abstractpub_date
2006-06-06 00:00:00pages
144-53issue
2eissn
0024-3205issn
1879-0631pii
S0024-3205(05)01277-4journal_volume
79pub_type
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