CRISPR-cas9 genome editing delivery systems for targeted cancer therapy.

abstract：:Three distinct peptidyldipeptidases (exopeptidases releasing carboxyl terminal dipeptide residues) can be solubilized from nerve terminal membrane fractions from whole rat brain or striatum, and separated by ion exchange chromatography. Brain angiotensin-converting enzyme (PDP-1) cleaves Hip-His-Leu, but not 80 nM [3H...

journal_title：Life sciences

authors： Cushman DW,Gordon EM,Wang FL,Cheung HS,Tung R,Delaney NG

更新日期：1983-01-01 00:00:00

abstract：:Alpha2-adrenoceptor (alpha2-AR)-regulated binding of the labelled GTP analog, guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS), to guanine-nucleotide-binding proteins (G proteins) was studied in human platelet membranes. Under optimal conditions, the potent alpha2-AR agonist, 5-bromo-6-(2-imidazolin-2-ylamino...

journal_title：Life sciences

authors： Gessi S,Campi F,Varani K,Borea PA

更新日期：1999-01-01 00:00:00

abstract：AIM:This study investigated the effect of voluntary motor effort during a low-intensity (30% maximal voluntary contraction [MVC]) muscle exercise training program on increasing muscle strength. MATERIALS AND METHODS:Eighteen young and healthy individuals were randomly assigned to one of three groups: high mental effor...

journal_title：Life sciences

authors： Jiang CH,Ranganathan VK,Siemionow V,Yue GH

更新日期：2017-06-01 00:00:00

abstract：:The effect of diabetes mellitus on serum cholesterol and aortic microsomal prostanoid synthesis was studied in cholesterol fed male Lewis rats. Normal, diabetic and diabetic rats treated with pancreatic islets were divided into three diet subgroups, control diet, control +2% cholesterol for 8 weeks and control +2% cho...

journal_title：Life sciences

authors： Myers SI,Bartula L,Linzel M,Phan T,Jung PJ,Merrell RC

更新日期：1990-01-01 00:00:00

abstract：:We investigated lithium-induced changes in norepinephrine (NE) catabolism. NE and its major metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenyl glycol (DHPG), ions such as lithium (Li(+)), magnesium (Mg(2+)), and potassium (K(+)) were measured in rat plasma and cerebral cortex using an HPLC meth...

journal_title：Life sciences

authors： Sastre E,Nicolay A,Bruguerolle B,Portugal H

更新日期：2005-07-01 00:00:00

abstract：:Muscarinic receptors can be pharmacologically classified into 3 types at the present time, however, five genes for the receptor have been identified. The muscarinic receptor types have unique antagonist selectivity, distribution and are linked to specific second messenger systems. The interaction between the muscarini...

journal_title：Life sciences

authors： Mei L,Roeske WR,Yamamura HI

更新日期：1989-01-01 00:00:00

abstract：:The effect of the vasopressin neuropeptide des-glycinamide (Arg8)-vasopressin (DGAVP) on reducing the acquisition of intravenous heroin self-administration in rats was analyzed. When rats reduced in body weight were allowed to self-administer heroin for 1 h per day in the presence of a fixed time, non contingent food ...

journal_title：Life sciences

authors： van Ree JM,Burbach-Bloemarts EM,Wallace M

更新日期：1988-01-01 00:00:00

abstract：AIMS:We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1 receptor antagonism or glycemic contro...

journal_title：Life sciences

authors： Abdelsaid M,Kaczmarek J,Coucha M,Ergul A

更新日期：2014-11-24 00:00:00

abstract：:Female white-footed mice (Peromyscus leucopus) were injected twice daily with 5, 10, 50, 100 micrograms melatonin (MEL) or saline. Injections were given for 7 weeks at 2 and 12 hours after lights-on under a long day (LD 16:8) photoperiod. Afternoon administration of MEL induced gonadal regression, although a dose of 5...

journal_title：Life sciences

authors： Hall ES,Lynch GR

更新日期：1985-08-26 00:00:00

abstract：:The reproductive system effects of cocaine were studied in male rats. The analysis included measurements of circulating levels of luteinizing hormone (LH) and testosterone (T) by radioimmunoassay (RIA). The weights of the testes and sex accessory organs were also assessed and compared with control animals. Dosage leve...

journal_title：Life sciences

authors： Berul CI,Harclerode JE

更新日期：1989-01-01 00:00:00

abstract：AIMS:Excessive production of nitric oxide (NO) and reactive oxygen species (ROS) in sepsis modulates different cell functions. Since the sepsis severity is associated with the degree of platelet activation, we decided to investigate the role of systemic generation of NO and ROS in modulating the platelet adhesion of li...

journal_title：Life sciences

authors： Casarin AL,Lopes-Pires ME,Morganti RP,Antunes E,Marcondes S

更新日期：2011-11-21 00:00:00

abstract：AIMS:This study was performed to examine whether hypertension affects the sympathetic transmission to resistance vessels of pithed rats via inhibitory presynaptic cannabinoid CB1 receptors and whether endocannabinoids are involved in this response. MATERIALS AND METHODS:We compared uninephrectomised rats rendered hype...

journal_title：Life sciences

authors： Toczek M,Schlicker E,Grzęda E,Malinowska B

更新日期：2015-10-01 00:00:00

abstract：:The structure of a new crystal form of leucine-enkephalin has been determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and both have extended peptide backbone conformations with side-chains arranged alternately above and below the backbone planes. The two pentapeptides are hydro...

journal_title：Life sciences

authors： Mastropaolo D,Camerman A,Ma LY,Camerman N

更新日期：1987-05-18 00:00:00

abstract：:Triiodothyronine (T3) increases phosphoglycerate mutase (PGAM) specific activity in rat skeletal and cardiac muscles. This increase is concomitant with an increase in the proportion of phosphoglycerate mutase isozymes which contain type-M subunit. Propylthiouracil (PTU), an anti-hormone, not only decreases phosphoglyc...

journal_title：Life sciences

authors： Esteller M,Ureña J,Carreras J,Martelly I,Climent F

更新日期：1994-01-01 00:00:00

abstract：AIMS:Chemo-resistance still was the main obstacle for AML patients, more effective and less toxic forms of therapies were desperately needed. Metformin, a classic hypoglycemic drug for diabetes recently delivered us a new identity that it exerted anti-tumor activity through suppressing mTOR in various tumors. But the a...

journal_title：Life sciences

authors： Yuan F,Cheng C,Xiao F,Liu H,Cao S,Zhou G

更新日期：2020-02-15 00:00:00

abstract：:S-adenosylmethionine and adenosine levels in the rat pineal gland were determined by high-performance liquid chromatography after fractionation of the pineal extracts. The concentration of S-adenosylmethionine follows a circadian rhythm and is about three times higher during the day (2.5 nmol/gland) than the night (1....

journal_title：Life sciences

authors： Chabannes B,Sarda N,Cronenberger L,Pacheco H

更新日期：1984-08-06 00:00:00

abstract：AIMS:Steroid hormones and steroid receptors (SRs) play a crucial role in spermatogenesis. Steroid receptor coregulators are the major determinants of SR functioning, and any alteration in their expression is known to be associated with impaired spermatogenesis. Since Bisphenol A (BPA) exposure leads to an impairment of...

journal_title：Life sciences

authors： Salian S,Doshi T,Vanage G

更新日期：2009-07-03 00:00:00

abstract：:The addition of the tumor-promoting phorbol ester 12-O-tetradecanoyl phorbol-13-acetate resulted in activation of calcium-sensitive phospholipid-dependent protein kinase which was dependent on the presence of phospholipid but was essentially independent of calcium. Fluphenazine, which is an effective inhibitor of the ...

journal_title：Life sciences

authors： Donnelly TE Jr,Jensen R

更新日期：1983-11-28 00:00:00

abstract：:Somatostatin (SS) acts as a universal endocrine off-swich, and also inhibits the growth of neuroendocrine tumors through its specific receptors. Small cell lung cancer (SCLC) demonstrates some neuroendocrine characteristics and has been proposed as a candidate for treatment with SS and its analogues. In the present st...

journal_title：Life sciences

authors： Fujita T,Yamaji Y,Sato M,Murao K,Takahara J

更新日期：1994-01-01 00:00:00

abstract：AIMS:Fenofibrate is a peroxisome proliferator-associated receptor alpha agonist (PPARα) used clinically for the management of dyslipidemia and is a myocardial fatty acid oxidation stimulator. It has also been shown to have cardiac anti-hypertrophic properties but the effects of fenofibrate on the development of eccentr...

journal_title：Life sciences

authors： Dhahri W,Couet J,Roussel É,Drolet MC,Arsenault M

更新日期：2013-01-17 00:00:00

abstract：AIMS:Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are...

journal_title：Life sciences

authors： Cui YL,Xue RQ,Xi He,Ming Zhao,Yu XJ,Liu LZ,Wu Q,Si Yang,Li DL,Zang WJ

更新日期：2019-04-01 00:00:00

abstract：:The present work aims to document, in a previously described animal model of Parkinson (double bilateral striatal injection of 6-OHDA), the possible modifications of circadian markers rhythms i.e. temperature (T), heart rate (H) and locomotor activity (A) registered continuously by telemetry, in order to evaluate a po...

journal_title：Life sciences

authors： Ben V,Bruguerolle B

更新日期：2000-08-18 00:00:00

abstract：:This study examined the role of marijuana smoking in the pathogenesis of human lung cancer by measuring DNA damage in alveolar macrophages (AM). The alkaline unwinding method was used to determine DNA single-strand breaks in AM lavaged from non-smokers [NS] and smokers of marijuana [MS], tobacco [TS] or cocaine [CS], ...

journal_title：Life sciences

authors： Sherman MP,Aeberhard EE,Wong VZ,Simmons MS,Roth MD,Tashkin DP

更新日期：1995-01-01 00:00:00

abstract：AIMS:Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right ventricular (RV) function and may mediate RVF. MATERIALS AND METHODS:We analyzed mRNA of human non-failing...

journal_title：Life sciences

authors： Williams JL,Cavus O,Loccoh EC,Adelman S,Daugherty JC,Smith SA,Canan B,Janssen PML,Koenig S,Kline CF,Mohler PJ,Bradley EA

更新日期：2018-03-01 00:00:00

abstract：:It is known that K(ATP) channel openers inhibit the release and refilling of Ca(2+) from intracellular stores. The present study was designed to test the effects of levcromakalim in human umbilical artery (HUA) rings stimulated by serotonin (5-HT) and KCl in Ca-free medium. Umbilical cords were obtained at vaginal or ...

journal_title：Life sciences

authors： Tufan H,Ayan-Polat B,Tecder-Unal M,Polat G,Kayhan Z,Oğüş E

更新日期：2003-02-07 00:00:00

abstract：:Vascular endothelial cells have been found to produce a relaxant mediator, identified as nitric oxide (NO) and implicated in numerous physiological functions. Subsequently, there has been an intensive search for accurate and specific detection methods to measure biological NO production. In the present study, we compa...

journal_title：Life sciences

authors： Privat C,Lantoine F,Bedioui F,Millanvoye van Brussel E,Devynck J,Devynck MA

更新日期：1997-01-01 00:00:00

abstract：:Synthetic human pancreatic Growth Hormone-Releasing Factor (hpGRF) elevated the plasma concentration of growth hormone (GH) in young and adult domestic fowl. This in vivo effect of hpGRF appeared to be largely similar for both the 32 amino-acid (hpGRF 1-32) or 40 amino-acid (hpGRF 1-40) polypeptide, although the effec...

journal_title：Life sciences

authors： Scanes CG,Carsia RV,Lauterio TJ,Huybrechts L,Rivier J,Vale W

更新日期：1984-03-19 00:00:00

abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...

journal_title：Life sciences

authors： Chu FF,Esworthy RS,Shen B,Gao Q,Doroshow JH

更新日期：2019-12-15 00:00:00

abstract：AIMS:Interleukin-22 (IL-22) promotes thymus recovery and improves T-cell recovery in preclinical allogeneic hematopoietic cell transplant models. However, the correlation between IL-22 and thymus recovery is unknown in human transplant. MATERIALS AND METHODS:In this study, plasma IL-22 levels of transplanted humans we...

journal_title：Life sciences

authors： Shang L,Duah M,Xu Y,Liang Y,Wang D,Xia F,Li L,Sun Z,Yan Z,Xu K,Pan B

更新日期：2021-01-15 00:00:00

abstract：:The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced af...

journal_title：Life sciences

authors： Flórez J,Hurlé MA,Mediavilla A

更新日期：1982-11-15 00:00:00