Abstract：
:The effect of silymarin on different functions of mitochondria isolated from rat kidneys was studied. Addition of silymarin to mitochondria oxidizing succinate, induced stimulation of the respiratory State 4; while in mitochondria oxidizing NAD-dependent substrates, the drug produced inhibition of the oxygen consumption. It is also shown that silymarin induces mitochondrial swelling, a drop in the transmembrane potential, as well as Ca2+ release. It is proposed that due to its hydrophobic character, silymarin produces an alteration in the lipidic milieu of the inner membrane which is conductive to an inhibition of the electron transport in the NAD-CoQ span of the respiratory chain, as well as to the loss of the energy dependent accumulated Ca2+.
journal_name
Life Scijournal_title
Life sciencesauthors
Chávez E,Bravo Cdoi
10.1016/0024-3205(88)90542-5subject
Has Abstractpub_date
1988-01-01 00:00:00pages
975-81issue
12eissn
0024-3205issn
1879-0631pii
0024-3205(88)90542-5journal_volume
43pub_type
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