Abstract:
:Rats were exposed for ten months to 60 ppm of lead (Pb, as acetate) in drinking water to further assess cardiovascular effects of chronic Pb exposure. At the end of the treatment, mean blood Pb was 3.1+/-0.3 microg/dL in the control rats and 22.8+/-1.2 microg/dL in the Pb-exposed rats (means+/-SE, n=12 in each group); these values were not comparable to those of humans. Pb greatly increased plasma levels of noradrenaline (NA) and adrenaline (A), but not those of L-DOPA and dopamine; monoaminoxidase activity was augmented by Pb, mostly in the aorta and in the liver; the aorta, liver, heart and kidney showed discrete histopathological alterations in the Pb-exposed rats, in which plasma levels of nitric oxide (NO, determined as L-citrulline) were reduced. Pb was able to induce blood hypertension, resulting from increase of cardiac inotropism and, mostly, total peripheral resistance. These data were discussed also in relation to those obtained in our previous studies carried out in rats exposed to Pb in drinking water (15-60 ppm) for periods ranging from five to eighteen months. Pb appeared to increase both sympathetic nerve activity by central mechanisms (thus increasing plasma NA and A) and cyclic adenosine monophosphate (cAMP)-dependent availability of calcium ions (Ca++) for contractile mechanisms in the vascular and cardiac myocells (also through an increased vascular alpha2- and myocardial beta1-adrenoreceptor reactivity). The reduction of plasma NO, contributing to increase vascular resistance and cardiac inotropism, was explained as a result of actions of Pb on enzyme activities concerned with the kallikrein-kinin (KK) and renin-angiotensin-aldosterone (RAA) systems. It was concluded that chronic Pb exposure is able to affect selective neuroendocrine (i.e., catecholamine), au- tacoidal (i.e., KK and RAA) and transductional pathways (i.e., cAMP, NO, Ca++) involved in the cardiovascular function.
journal_name
Life Scijournal_title
Life sciencesauthors
Carmignani M,Volpe AR,Boscolo P,Qiao N,Di Gioacchino M,Grilli A,Felaco Mdoi
10.1016/s0024-3205(00)00954-1subject
Has Abstractpub_date
2000-12-15 00:00:00pages
401-15issue
4eissn
0024-3205issn
1879-0631pii
S0024320500009541journal_volume
68pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The effects of (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of tea, on Ca(2+)-permeable non-selective cation currents (NSCC) and voltage-operated Ca(2+) channels (VOCC) have been investigated in cultured rat aortic smooth muscle cells using the whole-cell voltage-clamp technique. Under the Cs(+)/t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.04.005
更新日期:2007-05-16 00:00:00
abstract::6-mercaptopurine (6-MP) has been used clinically for 40 years to maintain remission in patients with acute lymphoblastic leukemia (ALL). However, central nervous system (CNS) relapses frequently occur in patients with ALL who continuously receive anticancer drugs, including 6-MP, during remission maintenance therapy. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00637-2
更新日期:2000-01-01 00:00:00
abstract::The effects of isolation and water scheduling on mitogen induced lymphocyte proliferation were investigated. Isolated rats were animals which had been raised in group-housed conditions and then transferred to individual cages with ad lib access to water for a 1 or 2 week period. Water scheduled rats were maintained in...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90472-9
更新日期:1988-01-01 00:00:00
abstract:AIMS:The present study aimed to investigate the mechanism of bone repair mediated by recombination BMP-2 (rhBMP-2)/recombination CXC chemokine ligand-13 (rhCXCL13)-loaded hollow hydroxyapatite (HA) microspheres/chitosan (CS) composite. MATERIALS AND METHODS:Firstly, the biological activity of rhBMP-2 and rhCXCL13 rele...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116743
更新日期:2019-10-01 00:00:00
abstract::Guinea pig ileum longitudinal muscle/myenteric plexus preparations contain functional mu- and kappa-opioid receptors. A preparation with blocked kappa receptors was obtained by pretreating guinea pigs with 0.1-10.0 mg/kg intraperitoneal doses of a new kappa-selective affinity label, DIPPA (2-(3,4-dichlorophenyl)-N-met...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00076-3
更新日期:1997-01-01 00:00:00
abstract::The application of acetic acid to the hind leg of a frog will induce a spinally mediated wiping reflex only if the acetic acid concentration is above a certain threshold. By using this reflex as the basis of a test for nociception, we show that morphine sulfate is a potent analgesic in the frog when injected into the ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90333-8
更新日期:1983-11-21 00:00:00
abstract::Incubation of unfixed, frozen sections of rat pancreas with tritiated guanidinoethylmercaptosuccinic acid (GEMSA) resulted in a localization of [3H]-GEMSA autoradiographic grains over the islets of Langerhans, suggesting that a carboxypeptidase H-like enzyme occurs in the islet. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90072-5
更新日期:1987-06-29 00:00:00
abstract::Down syndrome (DS) is the most common chromosomal abnormality and is associated with an extra copy of the chromosome 21. Although several markers are commonly used during pregnancy for the screening of DS, the definitive diagnosis is based on karyotype after amniocentesis, which is an expensive and laborious analysis....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.09.003
更新日期:2004-12-10 00:00:00
abstract:AIMS:The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco), (α-L-gulurono-β-D mannurono), β-D-gluco-β-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.11.014
更新日期:2011-02-28 00:00:00
abstract::This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00043-6
更新日期:1995-02-17 00:00:00
abstract:AIMS:Sickle cell disease (SCD) pathogenesis leads to recurrent vaso-occlusive and hemolytic processes, causing numerous clinical complications including renal damage. As vasoconstrictive mechanisms may be enhanced in SCD, due to endothelial dysfunction and vasoactive protein production, we aimed to determine whether th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.08.021
更新日期:2014-11-04 00:00:00
abstract::Alpha-inhibin-92 (alpha-IB-92) has been characterized from human seminal plasma and found to be active in suppressing FSH release in vitro and in vivo. In order to determine if smaller fragments of this 92 amino acid peptide would still be active to suppress FSH release, we have evaluated 5 of these fragments for thei...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90100-7
更新日期:1994-01-01 00:00:00
abstract::The effects of melatonin treatment and pituitary transplants on serum total and free cholesterol levels, cholesterol esterification index, phospholipid levels and prolactin, thyroid-stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3) levels were examined in rats. Male rats were grafted an anterior pitu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00613-9
更新日期:1997-01-01 00:00:00
abstract::The effect of continuous treatment with the selective 5-HT1A agonist gepirone upon 5-HT2-mediated behavior and cortical 5-HT2 receptor binding sites was examined in naive rats or rats receiving noradrenergic (DSP4) or serotonergic (5,7-DHT) lesions. Continuous administration of gepirone in non-lesioned rats for 3, 7, ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90478-t
更新日期:1991-01-01 00:00:00
abstract:AIMS:We investigated the involvement of the renin angiotensin system (RAS) on the cardiorespiratory control in rats from dams fed with a low-protein diet. MAIN METHODS:Male offspring were obtained from dams fed a normoprotein diet (NP, 17% casein) and low-protein diet (LP, 8% casein) during pregnancy and lactation. Di...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118574
更新日期:2020-12-15 00:00:00
abstract::In order to capture hepatocellular carcinoma (HCC) cells in circulating peripheral blood, we made analysis to see if alpha-fetoprotein (AFP) mRNA exists in the peripheral blood obtained from patients with HCC and also, as a control, from hepatitis-viral-marker-positive patients without HCC and a healthy volunteer. As ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02138-9
更新日期:1995-01-01 00:00:00
abstract::The aim of the present study was to assess the effects of peanut (Arachis hypogaea L.) shell extracts (PSE) on lipases and to evaluate its potential development for the treatment of obesity. The peanut shells were extracted in 95% ethanol, and the extracts were screened for inhibitory effects on pancreatic lipase (PL)...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.11.012
更新日期:2006-05-08 00:00:00
abstract::Anorexia is induced by injection of alpha 1-adrenergic receptor agonists into the hypothalamic paraventricular nucleus (PVN) in rats. Of the agonists tested to date, cirazoline is the most potent when administered either into the PVN or systemically. The present experiments assess the effects of systemically administe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90057-v
更新日期:1992-01-01 00:00:00
abstract::The behavioral response induced by the intravesical instillation of capsaicin has been investigated in catheter-implanted, freely moving, conscious male and female rats. Intravesical instillation of capsaicin (25 nmol/rat in 0.5 ml) evoked an intense licking directed toward the lower abdominal and perineal skin which ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90054-x
更新日期:1994-01-01 00:00:00
abstract:AIM:Beta asarone is the major constituent of oil obtained from Acorus calamus, the Indian traditional medicine plant. Several studies have shown that beta asarone causes liver and cardiac damages but the reproductive toxicity is not well understood. The present study was initiated to investigate whether beta asarone ha...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.08.021
更新日期:2017-03-15 00:00:00
abstract::The influence of different neuropeptides related to pro-opiomelanocortin were tested on acquisition of heroin self-administration in rats. The animals were allowed to self-administer heroin intravenously on a continuous reinforcement schedule during 6 h daily sessions on 5 consecutive days. Treatment was performed sub...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90261-8
更新日期:1983-12-05 00:00:00
abstract::In a partially depolarized guinea pig papillary muscle preparation, BAY K8644 stimulated voltage-operated calcium channels, promoting slow action potentials; this effect was dose-dependent over a concentration range of 3 X 10(-7) M to 3 X 10(-6) M. Isoproterenol and histamine also induced slow action potentials by sti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90651-x
更新日期:1986-07-28 00:00:00
abstract:AIMS:We elucidated the therapeutic potential of human umbilical vein endothelial cells (HUVECs) for ameliorating progressive heart failure in a myocardial infarction (MI) rat model. MAIN METHODS:MI was induced by ligation of left anterior descending artery, and HUVEC was transplanted 1week after MI. Cardiac function w...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.02.009
更新日期:2014-04-17 00:00:00
abstract:AIMS:The objective of this study is to investigate glucosamine (GlcN) as a transcriptional regulator of iNOS and other genes in association with the dynamic O-GlcNAcylation of RNA polymerase II (RNAPII). MAIN METHODS:The LPS- and/or GlcN-stimulated transcriptional activities of various Gal4-binding site/TATA-box-conta...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.06.011
更新日期:2014-08-21 00:00:00
abstract::This study was designed to document possible changes in bupivacaine and its main metabolite, des-butyl-bupivacaine (PPX) kinetics in mice after a single 5 mg/kg injection of diltiazem. After a single 20 mg/kg i.p. dose of bupivacaine, kinetic parameters of bupivacaine were not statistically different but the ratio AUC...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00601-6
更新日期:1994-01-01 00:00:00
abstract::It was possible to assess that ACE inhibitors bound to two different sites on the enzymes which consist in two homologous domains. Accordingly, it was also shown that testis ACE which consists in a single domain exhibits only one site for inhibitors. The common binding site of both enzymes contains Zn2+, bears the enz...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90489-c
更新日期:1992-01-01 00:00:00
abstract::The present investigation was aimed at comparing the influence of the partial dopamine (DA) receptor agonist (-)-3-PPP (preclamol) on prolactin release in acutely hyperprolactinemic but otherwise intact female rats and female rats subjected to chronic DA depletion. One group of animals received daily vehicle injection...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90100-2
更新日期:1988-01-01 00:00:00
abstract::The effect of the three forms (CANP1, CANP2 & CANP3) of calf brain calcium activated neutral protease (CANP) on the hydrolysis of purified neurofilament triplet proteins was investigated. It was observed that: each of the purified neurofilament proteins, was hydrolyzed slowly by CANP2 whereas the hydrolysis of 150 KDa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90331-0
更新日期:1986-10-13 00:00:00
abstract::We investigated the inhibition of human cholinesterases by galanthamine, an alkaloid of the common snowdrop (galanthus nivalis). In vitro, the compound showed potent enzyme inhibition and 50-fold selectivity for acetylcholinesterase (EC 3.1.1.7) as opposed to butyrylcholinesterase (EC 3.1.1.8). There was no difference...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90429-u
更新日期:1990-01-01 00:00:00
abstract::Evidence for the ability of the opiate antagonist naloxone to block a variety of metabolic effects exerted by morphine and non-opiate drugs is reviewed. Naloxone prevents or reverses the following effects in the rat: (a) the chronic morphine-induced increase in liver [NADPH]; (b) the consequent chronic morphine-induce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90608-2
更新日期:1983-01-01 00:00:00