当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > The role of cannabinoid 1 receptor in the nucleus accumbens on tramadol induced conditioning and reinstatement.

The role of cannabinoid 1 receptor in the nucleus accumbens on tramadol induced conditioning and reinstatement.

Abstract：

AIMS:Previous investigations demonstrated that tramadol, as a painkiller, similar to morphine induces tolerance and dependence. Furthermore, the cannabinoid receptor 1 (CB1R) located in the nucleus accumbens (NAc) plays a critical role in morphine-induced conditioning. Therefore, the main objective of this study was to evaluate the role of NAc CB1R in tramadol induced conditioning and reinstatement. MAIN METHODS:In the present experiment, the effect of NAc CB1 receptors on tramadol induced conditioning was tested by microinjecting of arachidonylcyclopropylamide (ACPA, CB1R agonist) and AM 251 (CB1R inverse agonist) in the NAc during tramadol-induced conditioning in the adult male Wistar rats. In addition, the role of NAc CB1R in the reinstatement was also evaluated by injecting ACPA and AM 251 after a 10-days extinction period. KEY FINDINGS:The obtained data revealed that the administration of tramadol (1,2, and 4 mg/kg, ip) dose-dependently produced conditioned place preference (CPP). Moreover, intra-NAc administration of ACPA (0.25, 0.5, and 1 μg/rat) dose-dependently induced conditioning, while the administration of AM-251 (30, 60, and 120 ng/rat) induced a significant aversion. In addition, the administration of a non-effective dose of AM251 during tramadol conditioning inhibited conditioning induced by tramadol. On the other hand, the administration of ACPA after extinction induced a significant reinstatement. Notably, the locomotor activity did not change among groups. SIGNIFICANCE:Previous studies have shown that tramadol-induced CPP occurs through μ-opioid receptors. The data obtained in the current study indicated that CB1R located in the NAc is involved in mediating conditioning induced by tramadol. Besides, CB1R also plays a vital role in the reinstatement of tramadol-conditioned animals. It might be due to the effect of opioids on enhancing the level of CB1R.

journal_name

Life Sci

journal_title

Life sciences

authors

Sadeghi-Adl M,Sadat-Shirazi MS,Shahini F,Akbarabadi A,Khalifeh S,Borzabadi S,Nasehi M,Zarrindast MR

doi

10.1016/j.lfs.2020.118430

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

118430

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(20)31183-8

journal_volume

260

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Specific [3H]-spiroperidol binding sites in human prefrontal cortex: potential site multiplicity and overall serotonin-like selectivity.

    abstract：:[3H]-Spiroperidol specifically binds at sites in human prefrontal cortex. The binding of this ligand is apparently anomalous at 37 degrees C, with a substantial loss of specific binding occurring between 5 and 40 min incubation. However, at 21 degrees C, this loss of binding is not observed even at 60 min. At 21 degre...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90282-0

    authors： Andorn AC,Huang EH,Warren AE

    更新日期：1984-06-18 00:00:00

  • Studies on in vitro effect of free fatty acids on water content and osmotic fragility of rabbit (Lepus cuniculus) erythrocytes.

    abstract：:The effects of free fatty acids in the blood on osmotic fragility and water content of erythrocytes when combined with hyperthermia were investigated. The isotonic buffer, containing the fatty acid, was added to the erythrocyte suspension to a final concentration of 200 microM/L. The samples were kept for one hour in ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)01184-3

    authors： Kogawa H,Yabushita N,Nakajima T,Kageyama K

    更新日期：1998-01-01 00:00:00

  • Pain control by endogenous enkephalins is mediated by mu opioid receptors.

    abstract：:The analgesic effects of bestatin and thiorphan, two enzymatic inhibitors protecting endogenous enkephalins from their degradation, and those of DAGO and deltakephalin, respectively mu and delta opioid peptides, are assessed on the electrical stimulation test of the mouse tail. The relative analgesic potency of DAGO a...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90595-7

    authors： Chaillet P,Coulaud A,Fournié-Zaluski MC,Gacel G,Roques BP,Costentin J

    更新日期：1983-01-01 00:00:00

  • Malic enzyme response to triiodothyronine in the brain of neonatal rats.

    abstract：:Malic enzyme activity in the soluble fraction of the neonatal brain of hypothyroid rats was observed to be lowered as compared to that of the control animals (p less than 0.01). Administration of triiodothyronine to the neonates of control animals resulted in significant enhancement (p less than 0.001) in the activity...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90428-0

    authors： Thakare UR,Vijayan U,Sushila L,Shah DH

    更新日期：1987-12-28 00:00:00

  • Importance of iron location in iron-induced hydroxyl radical production by brain slices.

    abstract：:Iron imbalance has been implicated in oxidative injury associated with many brain diseases. The present study investigated the importance of iron location in hydroxyl radical (.OH) generation and the link between .OH production evaluated by the salicylate method and lipid peroxidation monitored by thiobarbituric acid-...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00638-x

    authors： Demougeot C,Marie C,Beley A

    更新日期：2000-06-16 00:00:00

  • Paradoxical effects of copper and manganese on brain mitochondrial function.

    abstract：:Defects in the mitochondrial genome have been associated with Parkinson's and Alzheimer's disease, and apoptosis can be triggered by the presence of energetically compromised mitochondria. Thus, in this study we have examined whether the divalent cations Cu2+ and Mn2+ could influence mitochondrial function in vitro. M...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)00948-1

    authors： Heron P,Cousins K,Boyd C,Daya S

    更新日期：2001-02-23 00:00:00

  • Evidence that diclofenac and celecoxib are thyroid hormone receptor beta antagonists.

    abstract：UNLABELLED:Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS:Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen to bind to nuclear receptors. MATERIALS AND METHODS:In silico screening predicted t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.01.013

    authors： Zloh M,Perez-Diaz N,Tang L,Patel P,Mackenzie LS

    更新日期：2016-02-01 00:00:00

  • Vitamin D3 attenuates lipopolysaccharide-induced cognitive impairment in rats by inhibiting inflammation and oxidative stress.

    abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117703

    authors： Mokhtari-Zaer A,Hosseini M,Salmani H,Arab Z,Zareian P

    更新日期：2020-07-15 00:00:00

  • Toxic effects of juncusol, a marsh plant phenolic extract, on estuarine fish and shrimp.

    abstract：:Juncusol, phenolic compound, was isolated from the black needlerush, Juncus roemerianus. Different concentrations of this extract were tested for toxicity against selected species of estuarine fish and grass shrimp. Juncusol was ten times more toxic to the various species of fish than to grass shrimp. At 2.0 ppm conce...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90317-4

    authors： de la Cruz AA,Miles DH,Chapatwala KD

    更新日期：1982-05-24 00:00:00

  • Cardiac effects of benzodiazepine receptor agonists and antagonists in the isolated rat heart: a comparative study.

    abstract：:Effects of PK 11195 and flumazenil on cardiac responses to diazepam, clonazepam and zolpidem were compared. Coronary flow rate was increased at relatively low doses of diazepam and decreased at higher doses. Clonazepam induced a dose-dependent increase, and zolpidem a decrease of coronary flow rate. PK 11195 reduced t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00411-1

    authors： Zeegers A,van Wilgenburg H,Leeuwin RS

    更新日期：1998-01-01 00:00:00

  • Differential effects of naloxone on basal and stress-induced release of ACTH and prolactin in the male rat.

    abstract：:The effect of i.v. injection of various doses of naloxone (NAL) on plasma adrenocorticotropin (ACTH) and prolactin (Prl) in conscious animals bearing an indwelling intrajugular catheter was assessed. The effects were evaluated in animals which were left undisturbed and in others subjected to either restraint or ether ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90426-8

    authors： Xu RK,McCann SM

    更新日期：1989-01-01 00:00:00

  • Tumor control by hypoxia-specific chemotargeting of iron-oxide nanoparticle - Berberine complexes in a mouse model.

    abstract：AIM:To evaluate the therapeutic efficacy of hypoxic cell-sensitizer Sanazole (SAN) -directed targeting of cytotoxic drug Berberine (BBN) and Iron-oxide nanoparticle (NP) complexes, to solid tumor in Swiss albino mice. MAIN METHODS:NP-BBN-SAN complexes were characterized by FTIR, XRD, TEM and Nano-size analyzer. This c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.12.036

    authors： Sreeja S,Krishnan Nair CK

    更新日期：2018-02-15 00:00:00

  • Specific binding of atrial natriuretic factor to renal glomeruli during day or night antiorthostatic suspension in the rat.

    abstract：:We observed a significant increase in plasma atrial natriuretic factor (ANF) in antiorthostatic hypokinetic suspension (AOH) rats after 2 h of suspension when the experiment was made during day. Plasma ANF was investigated in relation to renal glomerular ANF receptors during AOH at night. The aim of this study was 1) ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(88)80008-0

    authors： Gauquelin G,Schiffrin EL,Garcia R,Entresangles M,Cantin M,Gharib C

    更新日期：1988-01-01 00:00:00

  • What are the immune responses during the growth of Ehrlich's tumor in ascitic and solid form?

    abstract：:Traditionally, Ehrlich's tumor is used in experimental oncology to investigate the therapeutic capacity of different synthetic chemotherapeutic agents or to evaluate the antitumoral activity of different substances of natural origin. However, the understanding of immune mechanisms during Ehrlich carcinogenesis is stil...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118578

    authors： Feitosa IB,Mori B,Teles CBG,Costa AGD

    更新日期：2021-01-01 00:00:00

  • Alterations in Eukaryotic Elongation Factor complex proteins (EEF1s) in cancer and their implications in epigenetic regulation.

    abstract：AIMS:In the cell, both transcriptional and translational processes are tightly regulated. Cancer is a multifactorial disease characterized by aberrant protein expression. Since epigenetic control mechanisms are also frequently disrupted during carcinogenesis, they have been the center of attention in cancer research wi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116977

    authors： Biterge-Sut B

    更新日期：2019-12-01 00:00:00

  • Inhibition of immune cell proliferation with haloperidol and relationship of tyrosine hydroxylase expression to immune cell growth.

    abstract：:Previous studies indicated that exogenous dopamine and its agonists directly regulated mitogen-induced immune cell proliferation. In this study, we further investigated role of endogenous dopamine in immune cell growth. Haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of T ce...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00170-2

    authors： Tsao CW,Lin YS,Cheng JT

    更新日期：1998-01-01 00:00:00

  • Reverse tolerance to amphetamine evokes reverse tolerance to 5-hydroxytryptophan.

    abstract：:Repeated intermittent administration of amphetamine in mice caused reverse tolerance to 5-hydroxy-L-tryptophan (5-HTP)-induced head twitch, as well as to amphetamine-induced stereotypy. The repeated administration of 5-HTP alone also resulted in reverse tolerance in the head-twitch test. Daily pretreatment with halope...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90141-d

    authors： Karler R,Calder LD,Turkanis SA

    更新日期：1990-01-01 00:00:00

  • Renal glutathione homeostasis in compensatory renal growth.

    abstract：:Glutathione homeostasis was investigated in unilaterally nephrectomized and sham-operated rats. Following twelve days of compensatory renal growth, it was found that the concentrations of glutathione and glutathione disulfide in representative samples of the entire remnant right kidney from the nephrectomized rats wer...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90132-4

    authors： Zalups RK,Veltman JC

    更新日期：1988-01-01 00:00:00

  • Subtypes of the muscarinic receptor in smooth muscle.

    abstract：:Muscarinic receptors are expressed in smooth muscle throughout the body. In most instances, the muscarinic receptor population in smooth muscle is composed of mainly the M2 and M3 subtypes in an 80% to 20% mixture. The M3 subtype mediates phosphoinositide hydrolysis and calcium mobilization, whereas the M2 subtype med...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0024-3205(97)00433-5

    authors： Ehlert FJ,Ostrom RS,Sawyer GW

    更新日期：1997-01-01 00:00:00

  • Ginsenoside Rd promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha.

    abstract：AIMS:Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS:10mg/kg GS-Rd in ovariectomy (OV...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.11.002

    authors： Yan X,Hu G,Yan W,Chen T,Yang F,Zhang X,Zhao G,Liu J

    更新日期：2017-01-01 00:00:00

  • Covalent labeling of opioid receptors with 3H-D-Ala2-Leu5-enkephalin chloromethyl ketone. I. Binding characteristics in rat brain membranes.

    abstract：:The chloromethyl ketone derivative of D-Ala2-Leu5-enkephalin was synthesized in a radioactive form, and the resulting compound (3H-DALECK) was used to label opioid receptors. 3H-DALECK binds with high affinity, specificity and saturability to rat brain membranes. The number of sites labeled is 130 fmoles/mg protein. U...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90491-7

    authors： Szücs M,Belcheva M,Simon J,Benyhe S,Tóth G,Hepp J,Wollemann M,Medzihradszky K

    更新日期：1987-07-13 00:00:00

  • Losartan, a nonpeptide angiotensin II (Ang II) receptor antagonist, inhibits neointima formation following balloon injury to rat carotid arteries.

    abstract：:Angiotensin-converting enzyme inhibitors have been shown to inhibit intimal thickening following balloon catheterization of rat carotid arteries. To assess the role of the renin-angiotensin pathway and the angiotensin type-I (AT1) receptor in this effect, the nonpeptide Ang II antagonist losartan (DuP 753) or vehicle ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90298-p

    authors： Kauffman RF,Bean JS,Zimmerman KM,Brown RF,Steinberg MI

    更新日期：1991-01-01 00:00:00

  • Preventive effect of pyrroloquinoline quinone (PQQ) on biliverdin accumulation of the liver of chick embryo after glucocorticoid administration.

    abstract：:Administration of a high dose of hydrocortisone hemisuccinate sodium (0.25 mumol/egg) to 15-day-old fertilized hen's eggs caused accumulation of biliverdin in the embryonic liver. The responses were 10 to 20-fold higher than controls within 48 hr as a result of stimulation of biliverdin synthesis in the liver and the ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90222-o

    authors： Nishigori H,Ishida O,Ogihara-Umeda I

    更新日期：1993-01-01 00:00:00

  • Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages.

    abstract：:Lipopolysaccharide (LPS) has been known to induce endotoxin shock via production of inflammatory modulators such as tumor necrosis factor alpha (TNF-alpha), or nitric oxide (NO). In this study, we have examined the effect of naringin (NG), one of the flavonoids, on LPS-induced endotoxin shock in mice and NO production...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.04.051

    authors： Kanno S,Shouji A,Tomizawa A,Hiura T,Osanai Y,Ujibe M,Obara Y,Nakahata N,Ishikawa M

    更新日期：2006-01-11 00:00:00

  • Tonic pain response in mice: effects of sex, season and time of day.

    abstract：:Seasonal and diurnal variations in tonic pain reactions were examined in female and male CBA/J mice maintained in a 12/12 dark/light cycle, at controlled temperature and humidity conditions. Animals were injected into the dorsum of one hindpaw with a dilute (20 microl, 1%) formalin solution. Pain-related behaviors wer...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)02344-5

    authors： Perissin L,Facchin P,Porro CA

    更新日期：2003-01-10 00:00:00

  • Crosstalk between transforming growth factor-β1 and endoplasmic reticulum stress regulates alpha-smooth muscle cell actin expression in podocytes.

    abstract：AIMS:Transforming growth factor-β1 (TGF-β1) plays a significant role in epithelial-mesenchymal transition (EMT). Furthermore, endoplasmic reticulum (ER) stress also can induce EMT. However, the relationship among TGF-β1, ER stress and EMT in podocytes is still unclear. Consequently, this study examines the crosstalk ef...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.07.050

    authors： Chen CA,Chang JM,Chang EE,Chen HC,Yang YL

    更新日期：2018-09-15 00:00:00

  • Glucose gradient differences in subcutaneous tissue of healthy volunteers assessed with ultraslow microdialysis and a nanolitre glucose sensor.

    abstract：:The abdominal subcutaneous interstitium is easily accessible for monitoring glucose for Diabetes Mellitus research and management. The available glucose sensing devices demand frequent blood sampling by finger pricking for calibration. Moreover, there is controversy about the exact relationship between the levels of g...

    journal_title：Life sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0024-3205(02)01515-1

    authors： Tiessen RG,Rhemrev-Boom MM,Korf J

    更新日期：2002-04-21 00:00:00

  • The organ distribution of liposome-encapsulated and free cobalt in rats. Liposomes decrease the cardiac uptake of the metal.

    abstract：:Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90092-1

    authors： Szebeni J,Garcia R,Eskelson CD,Chvapil M

    更新日期：1989-01-01 00:00:00

  • Hydroxypropyl-beta-cyclodextrin increases aqueous solubility and stability of anandamide.

    abstract：:Anandamide (arachidonylethanolamide; AEA) is an endogenous ligand for the cannabinoid receptor and its pharmacological effects are under intensive study. However, AEA has a low aqueous solubility and stability which may restrict its use and may eventually endanger the reliability of the obtained results. In the presen...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00024-0

    authors： Jarho P,Urtti A,Järvinen K,Pate DW,Järvinen T

    更新日期：1996-01-01 00:00:00

  • Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats.

    abstract：:Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. In this study the cardio protective effect of Centella asiatica on myocardial marker enzymes and antioxidant enzymes ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.09.009

    authors： Gnanapragasam A,Ebenezar KK,Sathish V,Govindaraju P,Devaki T

    更新日期：2004-12-17 00:00:00