Abstract：
:Lesions of the serotonergic afferents to the hippocampus, by fimbrial transection or by 5,7-dihydroxytryptamine treatment, produce an increase in the Bmax of [3H]WB4101 to its nanomolar affinity binding site, with no effect on its picomolar affinity binding site or on [3H]prazosin binding. The nanomolar site is serotonergic as the serotonergic agonists, serotonin and 8-hydroxydipropylaminotetraline (8-OH-DPAT) have nanomolar affinity for [3H]WB4101 binding when studied in the presence of a prazosin mask (30 nM) of the alpha-1 component of [3H]WB4101 binding. The serotonin receptor antagonists metergoline, lysergic acid diethylamide and lisuride also have high nanomolar affinities while ketanserin, yohimbine, prazosin and noradrenergic agonists have affinities in the micromolar range. Fimbrial transection or 5,7-dihydroxytryptamine injections produced 32% and 44% increases in the Bmax of [3H]WB4101 binding in the presence of a prazosin mask. Serotonin competition for [3H]WB4101 binding was identical in control and experimental tissue from each lesion experiment. Although specific binding of [3H]WB4101 was increased, there was no change in the affinities or the percentages of the two binding components for serotonin competition with [3H]WB4101. These data suggest that removal of the serotonergic input to the hippocampus produces an increase in the Bmax of serotonin receptor binding sites labeled by [3H]WB4101.
journal_name
Life Scijournal_title
Life sciencesauthors
Morrow AL,Norman AB,Battaglia G,Loy R,Creese Idoi
10.1016/0024-3205(85)90009-8subject
Has Abstractpub_date
1985-11-18 00:00:00pages
1913-22issue
20eissn
0024-3205issn
1879-0631pii
0024-3205(85)90009-8journal_volume
37pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：AIMS:Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and inward rectifi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.02.028
更新日期：2019-03-15 00:00:00
abstract：AIMS:The aims of the study are to investigate whether the combination of adipose-derived stem cells (ADSCs) with decellularized extracellular matrix (dECM) of myocardium can exert synergistic therapeutic effects on acute MI and the underlying mechanism. MAIN METHODS:Myocardial dECM from fresh porcine myocardium was pr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116891
更新日期：2019-12-15 00:00:00
abstract：AIM:Muscle atrophy is a common symptom after nerve denervation. Myostatin propeptide, a precursor of myostatin, has been documented to improve muscle growth. However, the mechanism underlying the muscle atrophy attenuation effects of myostatin propeptide in muscles and the changes in gene expression are not well establ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.12.056
更新日期：2016-02-01 00:00:00
abstract：:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90183-7
更新日期：1982-10-18 00:00:00
abstract：:As a decrease in cholinergic neurons has been observed in Alzheimer's Disease (AD), therapeutic approaches to AD include inhibition of acetylcholinesterase to increase acetylcholine levels. Evidence suggests that acetylcholine release in the CNS is modulated by negative feedback via presynaptic M2 receptors, blockade ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00598-0
更新日期：1999-01-01 00:00:00
abstract：:The effect of naloxone upon neurologic deficit was evaluated in a model of transient forebrain ischemia in rats. Awake male Wistar rats were subjected to a 30 minute ischemia by occluding both common carotid arteries 8 days after cauterizing vertebral arteries. Administration of naloxone 1 or 5 mg/kg iv 10 minutes aft...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90068-8
更新日期：1986-02-03 00:00:00
abstract：:Cumulative damage in cells from aged people could lead to a greater fragility against acute oxidative stress. The effects of acute oxidative stress on cell viability, cAMP and cGMP concentrations, and protein synthesis rates were studied in lymphocytes from 25 young and 26 elderly subjects. Lymphocytes were exposed to...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00231-8
更新日期：1998-01-01 00:00:00
abstract：:In this study, we evaluated whether butein can inhibit the effects of tumor necrosis factor alpha (TNF-alpha), an inflammatory mediator, in intestinal epithelial HT-29 cells. Butein significantly inhibited TNF-alpha-induced interleukin 8 (IL-8) secretion and mRNA expression. Moreover, butein suppressed the expression ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.09.024
更新日期：2007-11-10 00:00:00
abstract：:Female white-footed mice (Peromyscus leucopus) were injected twice daily with 5, 10, 50, 100 micrograms melatonin (MEL) or saline. Injections were given for 7 weeks at 2 and 12 hours after lights-on under a long day (LD 16:8) photoperiod. Afternoon administration of MEL induced gonadal regression, although a dose of 5...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90549-1
更新日期：1985-08-26 00:00:00
abstract：:We developed an experimental model to study the effect of daily cocaine administration on the mucosal immune system during murine acquired immune deficiency syndrome (MAIDS). Mice were infected with LP-BM5 murine leukemia virus, a retrovirus which causes immunosuppression with development of functional murine AIDS. Mi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00874-4
更新日期：1994-01-01 00:00:00
abstract：:Sphinganine (SP) pre-treatment potentiated the retinoic acid (RA)-induced (4-96h exposures) differentiation and increase of alkaline phosphatase (ALP) activity. A higher percentage of SP pre-treated cells in RA exposures resembled mature myelocytes or granulocytes; greater increase in ALP activity was observed. In cel...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90688-y
更新日期：1993-01-01 00:00:00
abstract：:An exclusively milk formula diet stunted the growth of mice immediately following weaning. Milk-fed mice displayed a low-frequency profile of exploratory behavior, while pellet-fed mice showed high-frequency exploration. In contrast to exploratory behavior, feeding behavior did not differ significantly between milk- a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.041
更新日期：2005-11-26 00:00:00
abstract：:Administration of cyclosporine (CS) as an immunosuppressive agent in clinical transplantation is associated with multiple side effects including nephrotoxicity and hypertension. These two effects could be related in that the renal changes may be secondary to alterations in organ blood flow. The present studies investi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90080-4
更新日期：1987-06-29 00:00:00
abstract：:This study examined the effects of chronic treatment of a new phosphodiesterase type 5 inhibitor, DA-8159, on endothelial dysfunction in stroke-prone spontaneously hypertensive rats (SHR-SP). Six-week-old male SHR-SP were divided into 4 groups; vehicle control, DA-8159 1, 3, and 10 mg/kg/day. During a 32-week experime...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.042
更新日期：2006-02-09 00:00:00
abstract：AIMS:The aims of the present study were to investigate the effect of crebanine on memory and cognition impairment in mice and to elucidate the underlying molecular mechanisms. MAIN METHODS:The memory-enhancing effects of crebanine were assessed with a water maze test using scopolamine-induced amnesic mice. The molecul...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.06.017
更新日期：2012-08-21 00:00:00
abstract：:Dehydroepiandrosterone (DHEA), an adrenal steroid of no known biological function, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). DHEA inhibited the growth of two stains of HeLa and WI-38 cells in culture. One of the HeLa strains, TCRC-2, was about 10x as sensitive to growth inhibition a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90557-6
更新日期：1986-04-21 00:00:00
abstract：:The specific binding of 35S-t-butylbicyclophosphorothionate (TBPS) was studied in synaptosomal membranes of rat cerebral cortex. The displacing potencies of eleven CNS depressants and three convulsants were determined in the presence of 1 microM GABA and 10 nM R 5135. GABA enhanced the displacing potencies of depressa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90589-9
更新日期：1988-01-01 00:00:00
abstract：:Almost all diabetic complications are known to be associated with vascular dysfunctions of different tissues. Oxidative stress, on the other hand, has been implicated in the pathogenesis of diabetes mellitus. Therefore in the present study we have investigated the correlation between redox status and oxidative stress ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00662-3
更新日期：2003-10-03 00:00:00
abstract：:Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.117891
更新日期：2020-09-01 00:00:00
abstract：AIMS:Hepatocyte growth factor (HGF) modulates intestinal epithelial cell proliferation and migration. We previously reported that systemic administration of recombinant human HGF (rh-HGF) ameliorated experimental colitis. However, an increase in serum HGF concentrations may induce undesired systemic effects, limiting t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.06.019
更新日期：2011-08-15 00:00:00
abstract：AIMS:Uric acid nephropathy (UAN) is due to excessive uric acid, which leads to hyperuricemia and kidney damage via the deposition of urate microcrystals in the kidneys. Iridoid glycosides of Paederia scandens (IGPS) is a major active component isolated from the traditional Chinese herb P. scandens (LOUR.) MERRILL (Rubi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.08.013
更新日期：2012-10-05 00:00:00
abstract：:Ginkgo biloba extract (GBE) has been used clinically for improving peripheral vascular diseases in France and Germany. In the present study, to clarify the pharmacological properties of vasodilation produced by GBE, we examined the effect of GBE and quercetin, one of the ingredients in GBE, on the thoracic aorta isola...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01303-0
更新日期：2001-10-05 00:00:00
abstract：AIMS:In myocardial ischemia-reperfusion (MI/R) injury, impaired autophagy function worsens cardiomyocyte death. AMP-activated protein kinase (AMPK) is a heterotrimeric protein that plays an important role in cardioprotection and myocardial autophagic function. AMPKα1 and α2 are localized primarily in the cytoplasm and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.04.002
更新日期：2019-05-15 00:00:00
abstract：:We determined whether two naturally occurring steroids, cortisol and 17beta-estradiol (E2), can rapidly modulate the activity of an important membrane protein, human erythrocyte (RBC) Na+,K+-ATPase, an enzyme that does not bind either hormone directly. We also determined the membrane binding locations for cortisol and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00360-4
更新日期：1999-01-01 00:00:00
abstract：:Histidine decarboxylase (HDC) activity and histamine content were measured in endoscopic gastric biopsy specimens of 19 control subjects with normogastrinemia and 6 patients with hypergastrinemia. In controls, the HDC activity was 3 fold higher in fundic mucosa (120 +/- 13 fmol/min/mg protein, mean +/- S.E.) than in a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90424-a
更新日期：1991-01-01 00:00:00
abstract：:The present study examined the discriminative stimulus and response rate-decreasing effects of kappa opioids in pigeons trained to discriminate a 0.017 mg/kg dose of bremazocine from saline. Bremazocine, spiradoline, CI977, U69,593 and U50,488 substituted completely for the bremazocine stimulus in a dose-dependent and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90115-5
更新日期：1994-01-01 00:00:00
abstract：:Radio-binding assay, bioassay and HPLC detection were used to observe the antagonistic effects of dextrorphan on PCP's actions. Dextrorphan displayed high affinity to PCP receptor in the rabbit mesenteric blood vessels. It had weak PCP-like bioactivity, but could antagonize PCP's action dose-dependently in vitro study...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90502-9
更新日期：1987-06-15 00:00:00
abstract：:An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (> 50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sir...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90109-0
更新日期：1994-01-01 00:00:00
abstract：:Immunoreactive atrial natriuretic peptide (ir-ANP) was measured in the follicular fluid of pig ovarian follicle, and rabbit ovarian homogenates and perfusates using a specific radioimmunoassay (RIA). Serial dilution curves made with the extracts of follicular fluid, ovarian homogenates and perfusates using SepPak C18 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90425-6
更新日期：1989-01-01 00:00:00
abstract：AIMS:Dorsal root ganglia contain heterogeneous populations of primary afferent neurons that transmit various sensory stimuli. This functional diversity may be correlated with differential expression of voltage-gated K(+) (Kv) channels. Here, we examine cellular distributions of Kv4 pore-forming and ancillary subunits t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.07.007
更新日期：2012-09-17 00:00:00
