Presence of immunoreactive atrial natriuretic peptide in follicular fluid, ovary and ovarian perfusates.

abstract：:The anticonvulsant effects and duration of protective action of midazolam against Metrazol induced seizures were studied in 528 rats aged 7,12,18,25 and 90 days. The doses of 0.025, 0.05, 0.25, 0.5 and 1.0 mg/kg were administered immediately before Metrazol (100 mg/kg in all but 18-day-old animals where 90 mg/kg were ...

journal_title：Life sciences

authors： Kubová H,Mares P

更新日期：1992-01-01 00:00:00

abstract：:Rhesus monkeys were trained to discriminate injections of saline from those of beta-carboline-3-carboxylic acid ethyl ester (beta-CCE), a compound that binds to the benzodiazepine receptor, but often has actions opposite to those of the benzodiazepines. A benzodiazepine agonist midazolam and low doses of a specific be...

journal_title：Life sciences

authors： Takada K,Winger G,Cook J,Larscheid P,Woods JH

更新日期：1986-03-17 00:00:00

abstract：:There is a significant need to evaluate the therapeutic potential of natural products and other compounds purported to be hepatoprotective. Acetaminophen-induced liver injury, especially in mice, is an attractive and widely used model for this purpose because it is both clinically relevant and experimentally convenien...

journal_title：Life sciences

authors： Jaeschke H,McGill MR,Williams CD,Ramachandran A

更新日期：2011-04-25 00:00:00

abstract：AIMS:To design and screen a potent GLP-1/GIP/Gcg receptors triagonist with therapeutic potential in rodent animals with diabetes and obesity. MAIN METHODS:First, we obtained a 12-mer dual GIP/Gcg receptor agonist from a large combinatorial peptide library via high-throughput screening technique and then fused to the E...

journal_title：Life sciences

authors： Cui J,Shang A,Wang W,Chen W

更新日期：2020-11-01 00:00:00

abstract：:Virgin, male Sprague-Dawley rats were used to study the production of cardiac failure by a single subcutaneous injection of 85 mg/kg dl-isoproterenol (ISO) and the possible preservation of cardiac function by a pre-treatment of 50 mg/kg verapamil (VER) 5 min prior to 85 mg/kg ISO. At 24 hrs after drug injections cardi...

journal_title：Life sciences

authors： Yeager JC,Whitehurst ME

更新日期：1982-01-18 00:00:00

abstract：:Interactions of the synthetic pyrethroid allethrin with the nicotinic acetylcholine (ACh) receptor/channel were studied in membranes from Torpedo electric organ. Allethrin did not inhibit binding of [3H]ACh to the receptor sites, but inhibited noncompetitively binding of [3H]perhydrohistrionicotoxin ([3H]H12-HTX) to t...

journal_title：Life sciences

authors： Abbassy MA,Eldefrawi ME,Eldefrawi AT

更新日期：1982-10-11 00:00:00

abstract：AIMS:This study aims to explore the effect and underlying mechanism of zoledronic acid (ZA) on the incidence of thyroid cancer (TC) tumorigenesis. MATERIALS AND METHODS:Human mononuclear cells THP-1 were differentiated into M2-like tumor associated macrophages (TAMs) by incubation with PMA followed by additional incub...

journal_title：Life sciences

authors： Lv J,Chen FK,Liu C,Liu PJ,Feng ZP,Jia L,Yang ZX,Hou F,Deng ZY

更新日期：2020-09-01 00:00:00

abstract：:Activated hepatic stellate cells (HSC; lipocytes; Ito cells) proliferate and are responsible for extracellular matrix synthesis during hepatic fibrogenesis. During activation, HSC undergo transdifferentiation into myofibroblasts expressing alpha-smooth muscle actin (alpha-SMA). Adenosine 3', 5'-cyclic monophosphate (c...

journal_title：Life sciences

authors： Shimizu E,Kobayashi Y,Oki Y,Kawasaki T,Yoshimi T,Nakamura H

更新日期：1999-01-01 00:00:00

abstract：:In frog brain membranes, equilibrium saturation binding of the opiate agonist: 3H-etorphine and of the opiate antagonist: 3H-diprenorphine is biphasic. In the presence of sodium ions (120 mM), "kinetic conversions" (unchanged Bmax) are observed: high affinity binding of the 3H-agonist is decreased while high affinity ...

journal_title：Life sciences

authors： Puget A,Jauzac P,Meunier JC

更新日期：1983-01-01 00:00:00

abstract：:The elevated plus-maze test has been widely used for screening of anxiolytic drugs and for exploring neurobiological bases of anxiety. In this study, we validated a new automated system that enables to record exploratory behavior in the elevated plus-maze test. This system, called cyberplus, consisted of ten pairs of ...

journal_title：Life sciences

authors： Torres C,Escarabajal MD

更新日期：2002-03-01 00:00:00

abstract：:The binding of norepinephrine (NE) to plasma proteins of fresh human blood obtained from healthy volunteers was studied by ultrafiltration at different NE concentrations and incubation times at 37 degrees C. At 1.7 nM L-[3H]-NE binding was approximately 25%. The binding was rapid and was not influenced by the incubati...

journal_title：Life sciences

authors： de Vera N,Cristófol RM,Rodríguez Farré E

更新日期：1988-01-01 00:00:00

abstract：:The influence of oral administration of rare earth element cerium (Ce) was studied in relation to metallothionein (MT) and glutathione (GSH) content in the organs of ICR mice, which were administered heavy metal cadmium (Cd) for comparison. Male ICR mice were divided into 9 groups: 1 control group, 4 cerium groups and...

journal_title：Life sciences

authors： Kawagoe M,Hirasawa F,Cun Wang S,Liu Y,Ueno Y,Sugiyama T

更新日期：2005-07-08 00:00:00

abstract：:The traditional Chinese medicines have been used clinically for a long time in some Asian countries, however, very few studies have been done to demonstrate the working mechanisms of these medicines using recently developed biochemical methodologies. In this study, we examined the anti-inflammatory effect of Huang-Lia...

journal_title：Life sciences

authors： Dai Y,Miki K,Fukuoka T,Tokunaga A,Tachibana T,Kondo E,Noguchi K

更新日期：2000-01-01 00:00:00

abstract：:The effect of psychoactive agents with different clinical actions: three sedative neuroleptics (trifluoperazine, alimemazine tartrate, chlorpromazine), an anticholinergic agent (trihexyphenidyl hydrochloride), two tricyclic antidepressants (imipramine, desipramine) and lithium carbonate on the rotational correlation f...

journal_title：Life sciences

authors： Lejoyeux M,Daveloose D,Mazière JC,Adès J,Viret J

更新日期：1993-01-01 00:00:00

abstract：:The effect of continuous treatment with the selective 5-HT1A agonist gepirone upon 5-HT2-mediated behavior and cortical 5-HT2 receptor binding sites was examined in naive rats or rats receiving noradrenergic (DSP4) or serotonergic (5,7-DHT) lesions. Continuous administration of gepirone in non-lesioned rats for 3, 7, ...

journal_title：Life sciences

authors： Yocca FD,Eison AS,Hyslop DK,Ryan E,Taylor DP,Gianutsos G

更新日期：1991-01-01 00:00:00

abstract：AIMS:Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery. M...

journal_title：Life sciences

authors： Yousefvand S,Hadjzadeh MA,Vafaee F,Dolatshad H

更新日期：2020-12-15 00:00:00

abstract：AIMS:Proton Nuclear Magnetic Resonance (NMR) based metabolomics analysis is extensively used to explore the metabolic profiling of biofluids. This approach was used for the analysis of metabolites in serum of patients with major types of muscular dystrophy in early phase of the disease. MATERIAL AND METHODS:Proton NMR...

journal_title：Life sciences

authors： Srivastava NK,Annarao S,Sinha N

更新日期：2016-04-15 00:00:00

abstract：:Much evidence has gathered that nitric oxide (NO) signaling, via cGMP-dependent mechanisms, may activate pro-survival pathways in hippocampal neurons and inhibit apoptosis. Past research has revealed that the enhancement of monoaminergic neurotransmission via exercise or treatment with antidepressant medications leads...

journal_title：Life sciences

authors： Chen MJ,Russo-Neustadt AA

更新日期：2007-09-29 00:00:00

abstract：:Losartan, a recently developed nonpeptide angiotensin II (Ang II) receptor antagonist, was administered orally to 10-week-old spontaneously hypertensive rats (SHR) for 2 weeks. Cardiac weight and tissue Ang II, as well as plasma renin activity (PRA) and Ang II, were determined. Treatment with Losartan (10 mg/kg per da...

journal_title：Life sciences

authors： Mizuno K,Tani M,Hashimoto S,Niimura S,Sanada H,Watanabe H,Ohtsuki M,Fukuchi S

更新日期：1992-01-01 00:00:00

abstract：:In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the b...

journal_title：Life sciences

authors： Theobald RJ Jr,Hoffman V

更新日期：1986-04-28 00:00:00

abstract：:Although effects of a metastasis suppressor gene, KiSS-1, have been postulated to be mediated by its receptor, hOT7T175, the mechanism of such effects remains unknown. This study was designed to evaluate the mechanism of how KiSS-1 works and to assess effects of a synthesized truncated KiSS-1 protein on the invasive a...

journal_title：Life sciences

authors： Yoshioka K,Ohno Y,Horiguchi Y,Ozu C,Namiki K,Tachibana M

更新日期：2008-08-29 00:00:00

abstract：:This study was undertaken to investigate whether or not alpha 2-adrenergic pathways would negatively modulate the hypothalamic somatostatin release in rats. To induce pharmacological changes in SS release, three groups of male Sprague-Dawley rats (n = 30/group) were separately anesthetized by ip administration of uret...

journal_title：Life sciences

authors： Lima L,Arce V,Tresguerres JA,Devesa J

更新日期：1993-01-01 00:00:00

abstract：:An increased level of melanin is characteristic of a large number of skin diseases, including acquired hyperpigmentation conditions such as melasma, post inflammatory melanoderma, and solar lentigo. Thus, there is an increasing need for the development of depigmenting agents. In order to evaluate the depigmenting capa...

journal_title：Life sciences

authors： Lee J,Jung K,Kim YS,Park D

更新日期：2007-06-27 00:00:00

abstract：:The present study is undertaken to investigate whether the phospholipase A(2) (PLA(2)) influences mRNA nucleocytoplasmic transport evaluated by nucleoside triphosphatase (NTPase) activity and mRNA export in isolated hepatic nuclear envelope. Isolated hepatic nuclei from rat liver were exposed to PLA(2) (10(-5) approxi...

journal_title：Life sciences

authors： Li JX,Li ZQ,Pang YZ,Tang CS

更新日期：2003-07-11 00:00:00

abstract：:We have confirmed that hypoxia elicits a substantial rise in blood choline levels in young adult rats. An intravenous infusion of tracer quantities of [2H4]-Ch, serial measurements of blood [2H0]-Ch and [2H4]-Ch, and a simple pharmacokinetic model were used to assess the bidirectional flux of choline between the centr...

journal_title：Life sciences

authors： Jenden DJ,Scremin OU,Roch M,Li G

更新日期：1996-01-01 00:00:00

abstract：:The regulation of the production of platelet-derived growth factor (PDGF) and the influence of high glucose concentration, eicosapentaenoic acid (EPA) were studied in cultured human umbilical vein endothelial cells (HUE). The PDGF production of HUE increased markedly depending on glucose concentration. However, EPA (3...

journal_title：Life sciences

authors： Mizutani M,Okuda Y,Suzuki S,Sawada T,Soma M,Yamashita K

更新日期：1995-01-01 00:00:00

abstract：:Increase of intracellular reactive oxygen species (ROS) has been proposed to cause endothelial injury, and oxidized LDL (oxLDL) actions are associated with an early increase of ROS. Estrogen protects vascular cells partly via its antioxidant effects and by preventing lipid peroxidation. However, whether it can inhibit...

journal_title：Life sciences

authors： Yen CH,Hsieh CC,Chou SY,Lau YT

更新日期：2001-12-14 00:00:00

abstract：:Effects of amphetamine on concentrations of dopamine, norepinephrine and serotonin in several monoamine-containing cell body and terminal regions were examined left and right separately in rats. Results suggest that amphetamine reduced the L-R asymmetry of most of these measures, and this effect is more significant in...

journal_title：Life sciences

authors： Lee EH,Huang SL,Chai CY

更新日期：1987-04-06 00:00:00

abstract：:To determine whether rat retinal photoreceptor cells produce inhibin, a molecule closely related to activin, a multifunctional growth factor in the transforming growth factor beta superfamily (TGF beta), we have conducted immunohistochemistry using specific antibodies for inhibin which were raised against a synthetic ...

journal_title：Life sciences

authors： Ying SY,Li SQ,Zhang Z

更新日期：1995-01-01 00:00:00

abstract：:[3H]ET (etorphine), which is considered either as an "universal" ligand or a mu agonist, interacts with identical affinities KD = 0.33-0.38 nM to hybrid cells and rabbit cerebellum, pure delta and mu-enriched opioid receptor preparations, respectively. In rat brain tissue, [3H]ET binding is inhibited by DAGO (Tyr-D-Al...

journal_title：Life sciences

authors： Delay-Goyet P,Roques BP,Zajac JM

更新日期：1987-08-10 00:00:00