当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor.

The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor.

Abstract：

AIMS:The aims of the present study were to investigate the effect of crebanine on memory and cognition impairment in mice and to elucidate the underlying molecular mechanisms. MAIN METHODS:The memory-enhancing effects of crebanine were assessed with a water maze test using scopolamine-induced amnesic mice. The molecular mechanism was explored in silico by docking crebanine against acetylcholine binding proteins (AChBPs) and in vitro with a radioligand competition assay using (±)-[(3)H]-epibatidine. The pharmacological behavior was assessed by observing changes to the functional activity of α7-nAChRs expressed in Xenopus oocytes and by fluorescent assays on recombinant ligand gated ion channel (LGIC) receptors expressed in mammalian cells. KEY FINDINGS:The administration of crebanine significantly improved the cognitive deficits induced by scopolamine, as measured by the water maze test. The docking results demonstrated that crebanine bound to the active binding site of the AChBP template with a good docking energy. Crebanine significantly inhibited the binding of (±)-[(3)H]-epibatidine to AChBPs with K(i) values of 179 nM and 538 nM for Ls and Ac, respectively. Further functional assays performed using two separate protocols indicated that crebanine is an antagonist of the α7-nAChR with an IC(50) of 19.1μM. SIGNIFICANCE:The observed actions of crebanine against amnesia and its effect on α7-nAChRs will be beneficial for target-based drug design; crebanine or its scaffold can be used as the starting point to develop a drug for Alzheimer's disease. The cognition-enhancing effects of crebanine and the underlying mechanism based on α7-nAChRs are consistent with its traditional use. These findings demonstrate the potential utility of crebanine in the development of neurodegenerative therapy.

journal_name

Life Sci

journal_title

Life sciences

authors

Rojsanga P,Boonyarat C,Utsintong M,Nemecz Á,Yamauchi JG,Talley TT,Olson AJ,Matsumoto K,Vajragupta O

doi

10.1016/j.lfs.2012.06.017

subject

Has Abstract

pub_date

2012-08-21 00:00:00

pages

107-14

issue

3-4

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(12)00325-6

journal_volume

91

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Effect of ipriflavone on glucocorticoid-induced osteoporosis in rats.

    abstract：:Ipriflavone, 7-isopropoxy-3-phenyl-4H-1-benzopyran-4-one, was administered orally for 12 weeks to male rats with prednisolone-induced osteoporosis. Microdensitometric analysis of a roentgenograph of the femurs revealed that ipriflavone increased the density of the distal metaphysis dose-dependently and tended to incre...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90265-1

    authors： Yamazaki I,Shino A,Shimizu Y,Tsukuda R,Shirakawa Y,Kinoshita M

    更新日期：1986-03-10 00:00:00

  • Role of alpha 1-adrenoceptor subtypes which mediate positive chronotropy in neonatal rat cardiac myocytes.

    abstract：:We investigated the involvement of alpha 1-adrenoceptor subtypes in the positive chronotropic response to norepinephrine (NE) in neonatal rat cardiac myocytes at day 3 of culture. The cardiac myocytes at day 3 of culture exhibited a dose-dependent positive chronotropic response to NE in the presence of propranolol, a ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)90155-4

    authors： Kimura H,Kawana S,Kanaya N,Sakano S,Miyamoto A,Ohshika H

    更新日期：1994-01-01 00:00:00

  • Decreases in repetitive extrasystole threshold in the conscious pig with myocardial infarct were reversed by tyrosine.

    abstract：:Reports indicate that the administration of tyrosine, the precursor amino acid for catecholaminergic neurotransmitters, may be beneficial under conditions of physiologic stress. We studied the effects of tyrosine on vulnerability to ventricular arrhythmia in conscious pigs with healing myocardial infarcts, and sham op...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90583-w

    authors： Pinto JM,Kirby DA,Maher TJ,Lown B

    更新日期：1991-01-01 00:00:00

  • Arachidonic acid inhibits Cl secretion in cultures of dog tracheal epithelium.

    abstract：:We studied the effects of arachidonic acid (AA) on Cl secretion across primary cultures of dog tracheal epithelium. Cell sheets showed mean values for baseline short-circuit current (Isc) and transepithelial resistance of 33.8 muA/cm2 and 360 omega.cm2 (n = 44). AA (5 x 10(-5) M) added to both sides increased Isc by 2...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90350-x

    authors： Mochizuki H,Chao AC,Widdicombe JH

    更新日期：1992-01-01 00:00:00

  • The effects of noribogaine and harmaline in rats trained with ibogaine as a discriminative stimulus.

    abstract：:In the present investigation, Fischer-344 rats were trained to discriminate 10.0 mg/kg of ibogaine from water using a pretreatment time of 60 minutes. Analysis of dose response data generated an ED50 of 4.6 mg/kg. The time course of the ibogaine (10.0 mg/kg) cue was also determined. The stimulus reached a maximum leve...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(96)00703-5

    authors： Helsley S,Rabin RA,Winter JC

    更新日期：1997-01-01 00:00:00

  • Production of human UDP-glucuronosyltransferases 1A6 and 1A9 using the Semliki Forest virus expression system.

    abstract：:Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detected by metabolic labeling, Western blot analyses and immunofluorescence...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00831-6

    authors： Forsman T,Lautala P,Lundström K,Monastyrskaia K,Ouzzine M,Burchell B,Taskinen J,Ulmanen I

    更新日期：2000-10-06 00:00:00

  • Isoflurane postconditioning with cardiac support promotes recovery from early brain injury in mice after severe subarachnoid hemorrhage.

    abstract：AIMS:Neurocardiac dysfunction is a life-threatening systemic consequence of subarachnoid hemorrhage (SAH) that contributes to triggering delayed cerebral ischemia (DCI). This study aimed to determine the impact of dobutamine cardiac support during isoflurane postconditioning on post-SAH DCI. MAIN METHODS:Male C57BL/6 ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.04.020

    authors： Mutoh T,Mutoh T,Sasaki K,Yamamoto Y,Tsuru Y,Tsubone H,Ishikawa T,Taki Y

    更新日期：2016-05-15 00:00:00

  • Validation of a behavioral recording automated system in the elevated plus-maze test.

    abstract：:The elevated plus-maze test has been widely used for screening of anxiolytic drugs and for exploring neurobiological bases of anxiety. In this study, we validated a new automated system that enables to record exploratory behavior in the elevated plus-maze test. This system, called cyberplus, consisted of ten pairs of ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)01476-5

    authors： Torres C,Escarabajal MD

    更新日期：2002-03-01 00:00:00

  • Glucose gradient differences in subcutaneous tissue of healthy volunteers assessed with ultraslow microdialysis and a nanolitre glucose sensor.

    abstract：:The abdominal subcutaneous interstitium is easily accessible for monitoring glucose for Diabetes Mellitus research and management. The available glucose sensing devices demand frequent blood sampling by finger pricking for calibration. Moreover, there is controversy about the exact relationship between the levels of g...

    journal_title：Life sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0024-3205(02)01515-1

    authors： Tiessen RG,Rhemrev-Boom MM,Korf J

    更新日期：2002-04-21 00:00:00

  • Inhibition by talipexole, a thiazolo-azepine derivative, of dopaminergic neurons in the ventral tegmental area.

    abstract：:A microiontophoretic study using rats anesthetized with chloral hydrate and immobilized with gallamine triethiodide was carried out to compare the effect of talipexole (B-HT 920 CL2:2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo [4,5-d]-azepine-dihydrochloride), a dopamine autoreceptor agonist, on dopaminergic neurons...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90071-i

    authors： Momiyama T,Sasa M,Takaori S

    更新日期：1991-01-01 00:00:00

  • The synovial-like membrane at the bone interface in loose total hip replacements contains high levels of extracellular group II phospholipase A2.

    abstract：:Progressive lysis of bone in loose total hip replacement has been ascribed to the capacity of the synovial-like membrane present at the bone interface to produce prostaglandin E2 and cytokines such as tumor necrosis factor (TNF alpha). Phospholipase A2 (PLA2) produces rate limiting precursor i.e. arachidonic acid in t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00342-6

    authors： Cirino G,Misasi M,Loffredo A,Sorrentino L,Caivano P,Bucci M,Cicala C

    更新日期：1996-01-01 00:00:00

  • Minireview. Evidence that dopamine is a neurotransmitter in peripheral tissues.

    abstract：:In the CNS, dopamine (DA) is a recognized neurotransmitter as well as a precursor for norepinephrine (NE) and epinephrine (EPI). In contrast to the CNS, DA has been assumed to be only a precursor in peripheral tissues. There is now, however, considerable evidence to support the hypothesis that it may function as a neu...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(83)90827-5

    authors： Lackovic Z,Neff NH

    更新日期：1983-04-11 00:00:00

  • Urantide attenuates myocardial damage in atherosclerotic rats by regulating the MAPK signalling pathway.

    abstract：OBJECTIVE:To explore the effect of urantide on atherosclerotic myocardial injury by antagonizing the urotensin II/urotensin II receptor (UII/UT) system and regulating the mitogen-activated protein kinase (MAPK) signalling pathway. METHODS:Atherosclerosis (AS) was established in rats by administering a high-fat diet an...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118551

    authors： Zhao J,Miao G,Wang T,Li J,Xie L

    更新日期：2020-12-01 00:00:00

  • Contribution of sulfate-reducing bacteria to homeostasis disruption during intestinal inflammation.

    abstract：:Alteration in microbial populations and metabolism are key events associated with disruption of intestinal homeostasis and immune tolerance during intestinal inflammation. A substantial imbalance in bacterial populations in the intestine and their relationships with the host have been observed in patients with inflamm...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2018.11.009

    authors： Figliuolo VR,Coutinho-Silva R,Coutinho CMLM

    更新日期：2018-12-15 00:00:00

  • The endocrine disruptor nonylphenol preferentially blocks cyclooxygenase-1.

    abstract：:The anthropogenic chemicals nonylphenol, bisphenol A, phthalic acid benzyl n-butyl ester, phthalic acid di-n-butyl ester and phthalic acid di(2-ethylhexyl) ester have been shown to possess sex hormone-like activity. To explore the possible actions of these chemicals on the autacoid synthesis in the body, we investigat...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01538-7

    authors： Fujimoto Y,Sakuma S,Inoue T,Uno E,Fujita T

    更新日期：2002-03-29 00:00:00

  • The role of the ventromedial hypothalamic area in periprandial glucoregulation.

    abstract：:There is a great deal of evidence that the ventromedial hypothalamic area (VMH) plays a significant role in glucoregulation. The present review synthesizes new and existing data in a coherent model of a hypothalamic glucoregulatory control system whose function is to stabilize blood glucose levels in the face of disco...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(85)90631-9

    authors： Storlien LH

    更新日期：1985-02-11 00:00:00

  • The utility of 2-hydroxypropyl-beta-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs.

    abstract：:The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or intrathecal (IT) routes. In ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90537-l

    authors： Yaksh TL,Jang JD,Nishiuchi Y,Braun KP,Ro SG,Goodman M

    更新日期：1991-01-01 00:00:00

  • Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors.

    abstract：:The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0024-3205(99)00282-9

    authors： Pertwee RG

    更新日期：1999-01-01 00:00:00

  • U50,488H postconditioning reduces apoptosis after myocardial ischemia and reperfusion.

    abstract：AIMS:Evidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to t...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2010.10.018

    authors： Tong G,Sun Z,Wei X,Gu C,Kaye AD,Wang Y,Li J,Zhang Q,Guo H,Yu S,Yi D,Pei J

    更新日期：2011-01-03 00:00:00

  • Inhibiting Rab27a in renal tubular epithelial cells attenuates the inflammation of diabetic kidney disease through the miR-26a-5p/CHAC1/NF-kB pathway.

    abstract：:The effect of exosomes on receptor cells participating in intercellular communication has been extensively studied, but the effect of exosomes on donor cells remains unclear. It has been reported that exosomes secreted by renal proximal tubular epithelial cells (PTECs) under different stimuli accelerate acute and chro...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118347

    authors： Li S,Jia Y,Xue M,Hu F,Zheng Z,Zhang S,Ren S,Yang Y,Si Z,Wang L,Guan M,Xue Y

    更新日期：2020-11-15 00:00:00

  • Dual in vitro effects of cortisol on cell turnover in the medaka esophagus via the glucocorticoid receptor.

    abstract：AIMS:Cortisol is a glucocorticoid in mammals, but has both gluco- and mineralocorticoid activities in teleost fish. Our previous in vivo studies on osmoregulatory esophagi of euryhaline fish showed that epithelial apoptosis for the simple epithelium in seawater and cell proliferation for the stratified epithelium in fr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2010.11.017

    authors： Takagi C,Takahashi H,Kudose H,Kato K,Sakamoto T

    更新日期：2011-01-31 00:00:00

  • Vitamin E, membrane fluidity, and blood pressure in hypertensive and normotensive rats.

    abstract：:Vitamin E treatment was found to lower blood pressure, and increase membrane fluidity in rats. The objectives of this study were to investigate the effects of the antioxidant, vitamin E, on the blood pressure and erythrocyte membrane fluidity in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Membrane fl...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00775-x

    authors： Pezeshk A,Derick Dalhouse A

    更新日期：2000-09-01 00:00:00

  • Evodiamine inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells via the Hippo-Yes-Associated Protein signaling pathway.

    abstract：AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117424

    authors： Zhao S,Xu K,Jiang R,Li DY,Guo XX,Zhou P,Tang JF,Li LS,Zeng D,Hu L,Ran JH,Li J,Chen DL

    更新日期：2020-06-15 00:00:00

  • Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes.

    abstract：:We used a sensitive and specific radioimmunoassay for acetylcholine (ACh), and detected significant amounts of ACh in the blood of various mammals, including humans. About 60% of human blood ACh was localized in mononuclear leukocytes. Human leukemic T-cell lines, used as T-lymphocyte models, contained both ACh and ch...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0024-3205(98)00131-3

    authors： Kawashima K,Fujii T,Watanabe Y,Misawa H

    更新日期：1998-01-01 00:00:00

  • Developmental and hormonal regulation of meltrin beta (ADAM19) expression in mouse testes during embryonic and postnatal life.

    abstract：:More than half of ADAM (a disintegrin and metalloprotease) family members are expressed in mammalian male reproductive organs such as testis and epididymis. The ADAM19 gene identified in mouse is a member of the ADAM family and is highly enriched in testes of a newborn mouse. The present study was performed to determi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.07.002

    authors： Bu SM,Yang YJ,Miao CL,Li HJ,Newcomer RG,Sang QX,Duan EK

    更新日期：2006-10-26 00:00:00

  • 23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells.

    abstract：:23-Hydroxybetulinic acid, a derivative of betulinic acid, was investigated for its apoptotic effect and the associated telomerase activity in human leukemia HL-60 cells. Apoptosis and bcl-2 were determined by flow cytometry analysis. A PCR-based telomeric repeat amplification protocol assay was used to detect telomera...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)02176-8

    authors： Ji ZN,Ye WC,Liu GG,Hsiao WL

    更新日期：2002-11-22 00:00:00

  • Characterization of quinone reductase, glutathione and glutathione S-transferase in human myeloid cell lines: induction by 1,2-dithiole-3-thione and effects on hydroquinone-induced cytotoxicity.

    abstract：:In this study, we have characterized quinone reductase (QR), glutathione (GSH), glutathione S-transferase (GST) and their induction by a chemoprotector, 1,2-dithiole-3-thione (D3T), in the human myeloid cell lines ML-1 and HL-60. In addition, we also examined the toxicity of hydroquinone (HQ), a benzene metabolite, to...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00626-1

    authors： Li Y,Lafuente A,Trush MA

    更新日期：1994-01-01 00:00:00

  • Variations in concentration of oxytocin and vasopressin in the paraventricular nucleus of the hypothalamus during the estrous cycle in rats.

    abstract：:Oxytocin (OT) and arginine-8-vasopressin (AVP) were measured by radioimmunoassay in micropunched hypothalamic neurosecretory nuclei of estrous cycling female Sprague-Dawley rats. In the paraventricular nucleus (PVN): the concentration (pg/microgram protein) of OT was significantly higher in rats in diestrus than durin...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90638-7

    authors： Greer ER,Caldwell JD,Johnson MF,Prange AJ Jr,Pedersen CA

    更新日期：1986-06-23 00:00:00

  • Centrally acting endogenous hypotensive substances in rats subjected to endotoxic shock.

    abstract：:Cerebroventricular perfusate (CVP) from rats subjected to endotoxic shock was infused into the lateral ventricle of the naive rat. This procedure produced a hypotensive response in the recipient rat which could be reversed by the intravenous injection of the opioid antagonist naltrexone. The degree of endotoxemic hypo...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90053-r

    authors： Xu T,Wang T,Han JS

    更新日期：1992-01-01 00:00:00

  • Melatonin treatment protects against sepsis-induced functional and biochemical changes in rat ileum and urinary bladder.

    abstract：:Sepsis is commonly associated with enhanced generation of reactive oxygen metabolites, which lead to multiple organ dysfunction. The aim of this study was to examine the role of melatonin, a potent antioxidant, in protecting the intestinal and bladder tissues against damage in a rat model of sepsis. Sepsis was induced...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2003.07.038

    authors： Paskaloğlu K,Sener G,Kapucu C,Ayanoğlu-Dülger G

    更新日期：2004-01-16 00:00:00