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Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat.

Abstract：

:There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and alpha-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drugs in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, alpha-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat.

journal_name

Life Sci

journal_title

Life sciences

authors

Jalil JE,Ebensperger R,Meléndez J,Acevedo E,Sapag-Hagar M,González-Jara F,Gálvez A,Pérez-Montes V,Lavandero S

doi

10.1016/s0024-3205(99)00097-1

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

1603-12

issue

18

eissn

0024-3205

issn

1879-0631

pii

S0024320599000971

journal_volume

64

pub_type

杂志文章

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