Abstract:
:The addition of the tumor-promoting phorbol ester 12-O-tetradecanoyl phorbol-13-acetate resulted in activation of calcium-sensitive phospholipid-dependent protein kinase which was dependent on the presence of phospholipid but was essentially independent of calcium. Fluphenazine, which is an effective inhibitor of the ability of this phorbol ester to stimulate proliferation in calcium-deprived non-neoplastic cells, inhibited the enzyme in the absence or presence of the phorbol ester (Ki = 16 microM). Fluphenazine inhibition was competitive with phospholipid but non-competitive with 12-O-tetradecanoyl phorbol-13-acetate.
journal_name
Life Scijournal_title
Life sciencesauthors
Donnelly TE Jr,Jensen Rdoi
10.1016/0024-3205(83)90298-9subject
Has Abstractpub_date
1983-11-28 00:00:00pages
2247-53issue
22eissn
0024-3205issn
1879-0631pii
0024-3205(83)90298-9journal_volume
33pub_type
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