Abstract：
:The aim of the present study was to investigate the existence of aging- and sex-related alterations in the permeability of the blood-brain barrier (BBB) in the rat, by calculating a unidirectional blood-to-brain transfer constant (Ki) for the circulating tracer [14C]-alpha-aminoisobutyric acid. We observed that: a) the permeability of the BBB significantly increased within the frontal and temporo-parietal cortex, hypothalamus and cerebellum in 28-30 week old rats, in comparison with younger animals; b) in several brain areas of female intact rats higher Ki values (even though not significantly different) were calculated at oestrus than at proestrus; c) in 1-week ovariectomized rats there was a marked increase of Ki values at the level of the frontal, temporo-parietal and occipital cortex, cerebellum and brain-stem. One can speculate that aging- and sex-related alterations in the permeability of the BBB reflect respectively changes in brain neurochemical system activity and in plasma steroid hormone levels.
journal_name
Life Scijournal_title
Life sciencesauthors
Saija A,Princi P,D'Amico N,De Pasquale R,Costa Gdoi
10.1016/0024-3205(90)90157-msubject
Has Abstractpub_date
1990-01-01 00:00:00pages
2261-7issue
24eissn
0024-3205issn
1879-0631pii
0024-3205(90)90157-Mjournal_volume
47pub_type
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