The protective effect of ApolipoproteinA-I on myocardial ischemia-reperfusion injury in rats.

abstract：:The initial stage of atherosclerotic plaque formation involves oxidation of the phosphatidyl-choline moiety of low density lipoprotein (LDL) and subsequent uptake by macrophages. Ongoing uptake in developing plaque also may involve oxidized LDL and would require an oxidizing environment in plaque lipids. Atherosclerot...

journal_title：Life sciences

authors： Piotrowski JJ,Shah S,Alexander JJ

更新日期：1996-01-01 00:00:00

abstract：:N(G)-Nitro-L-arginine methyl ester (L-NAME), inhibits the three isozymes of nitric oxide synthase (NOS) in vitro and in vivo. The mechanism of NOS inhibition by L-NAME is uncertain. L-NAME was a time-dependent inhibitor of neuronal NOS (nNOS). Concommitantly, L-NAME was hydrolyzed, non-enzymatically, to N(G)-Nitro-L-a...

journal_title：Life sciences

authors： Furfine ES,Carbine K,Bunker S,Tanoury G,Harmon M,Laubach V,Sherman P

更新日期：1997-01-01 00:00:00

abstract：:Renal handling of the aminoglycoside antibiotics gentamicin and tobramycin were studied before and after one hour of constant intravenous infusions adjusted to maintain a concentration of 15 micrograms/mL. A solitary renal autotransplant model in four conscious volume replete 40 Kg sheep was used. This unique surgical...

journal_title：Life sciences

authors： Bennett WM,McDougall J,Potocnik S,Wright RD,Whitworth JA

更新日期：1983-01-17 00:00:00

abstract：:The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus. In the present studies, this pharmacologic procedure has been examined as a potential method for estimating hypothalamic ...

journal_title：Life sciences

authors： Liu B,Kwok RP,Fernstrom JD

更新日期：1991-01-01 00:00:00

abstract：:The biochemical changes of the elements of cholinergic neurotransmission (choline acetyltransferase, ChAT; acetylcholinesterase, AChE; butyrylcholinesterase, BuChE; and muscarinic cholinergic receptors, mAChR) as well as the electrolyte content were studied in ischemic lumbar spinal cord segments of newborn pigs. Isch...

journal_title：Life sciences

authors： Tekulics P,Rakonczay Z,Szerdahelyi P,Kása P,Gulya K

更新日期：1990-01-01 00:00:00

abstract：AIMS:Liver fibrosis is a difficult problem in the medical field. We previously reported that curcumol, a bioactive substance, may inhibit the pathological angiogenesis of liver sinusoidal endothelial cells (LSECs) and play a good anti-hepatic fibrosis effect. However, the mechanism of curcumol inhibiting angiogenesis i...

journal_title：Life sciences

authors： Gao L,Yang X,Li Y,Wang Z,Wang S,Tan S,Chen A,Cao P,Shao J,Zhang Z,Zhang F,Zheng S

更新日期：2021-01-01 00:00:00

abstract：:Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...

journal_title：Life sciences

authors： Roman-Campos D,Cruz JS

更新日期：2014-03-07 00:00:00

abstract：:The potential effect of maternal caffeine ingestion upon total brain protein and the concentration of two prototype neuropeptides, thyrotropin-releasing hormone (TRH) and its derivative, cyclo (His-Pro) in neonates was examined during the nursing period in the context of variable maternal protein intake. Maternal caff...

journal_title：Life sciences

authors： Mori M,Wilber JF,Nakamoto T

更新日期：1983-11-21 00:00:00

abstract：:The in vitro and in vivo regulation of [3H]Ro 5-4864 binding to peripheral benzodiazepine receptors (PBR) by ion transport/exchange inhibitors was studied in the kidney. The potencies of 9-anthroic acid, furosemide, bumetanide, hydrochlorothiazide and SITS as inhibitors of [3H]Ro 5-4864 binding to renal membranes were...

journal_title：Life sciences

authors： Basile AS,Lueddens HW,Skolnick P

更新日期：1988-01-01 00:00:00

abstract：:The circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been determined in male and female rats at 3 weeks and at 2, 8, 14 and 20 months of age. All animals have a pronounced circadian pattern of aMT6s excretion under a 12 hour dark: 12 hour light cycle. A significant increase in aMT6s excretion is observe...

journal_title：Life sciences

authors： Yie SM,Liu GY,Johansson E,Brown C,Brown GM

更新日期：1992-01-01 00:00:00

abstract：:Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, ...

journal_title：Life sciences

authors： Novák P,Jackson AO,Zhao GJ,Yin K

更新日期：2020-09-15 00:00:00

abstract：:The effects of opioids on human subjective olfactory function have rarely been investigated. This is despite the fact that opioid receptors are widely distributed throughout the olfactory systems. Using an established validated test of subjective olfactory function, olfactory threshold, odor discrimination and odor id...

journal_title：Life sciences

authors： Lötsch J,Darimont J,Skarke C,Zimmermann M,Hummel T,Geisslinger G

更新日期：2001-09-28 00:00:00

abstract：:Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D1 receptor antagonist SCH 23390. CP 55,940 (0, 10, ...

journal_title：Life sciences

authors： Arnold JC,Hunt GE,McGregor IS

更新日期：2001-11-21 00:00:00

abstract：AIMS:Glycation of proteins leads to the formation of advanced glycation end products (AGEs, which have significant role in the pathophysiology of diabetes complications. d-ribose appears to be the most reactive among the naturally occurring sugars and contribute significantly to the generation of AGEs. Glycation also r...

journal_title：Life sciences

authors： Akhter F,Khan MS,Alatar AA,Faisal M,Ahmad S

更新日期：2016-04-15 00:00:00

abstract：:Individuals have an inherent capacity to cope with stressors in the form of stress adaptation. Apart from stress adaptation there is another well documented phenomenon known as cross stress adaptation. In this, there is a reduction in stress responsiveness to a novel stressor (in which the adapted organism had never e...

journal_title：Life sciences

authors： Chauhan E,Bali A,Singh N,Jaggi AS

更新日期：2015-09-15 00:00:00

abstract：AIMS:Poly (ADP-ribose) polymerase- (PARP)-1 is predominantly triggered by DNA damage. Overexpression of PARP-1 is known for its association with the pathogenesis of several CNS disorders, such as Stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington (HD) and Amyotrophic lateral sclerosis (ALS). NAD+ de...

journal_title：Life sciences

authors： Thapa K,Khan H,Sharma U,Grewal AK,Singh TG

更新日期：2021-02-15 00:00:00

abstract：:Oxidative stress (free radical generation exceeds antioxidant defense) occurs in many diseases and after exposure to certain chemicals. We automated assays estimating the antioxidant status of serum and lipid hydroperoxide concentrations using the Syva-30R automated analyzer. In this assay, the antioxidant status of s...

journal_title：Life sciences

authors： Mahle C,Dasgupta A

更新日期：1997-01-01 00:00:00

abstract：:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...

journal_title：Life sciences

authors： Maccarrone C,Jarrott B

更新日期：1988-01-01 00:00:00

abstract：AIMS:Mancozeb is a dithiocarbamate fungicide known to be genotoxic and induces tumors in rodents at various sites. There is no report in the literature about its genotoxicity in humans. Here, we investigated the association between mancozeb exposure and induction of genotoxic and proapoptotic changes in cultured human ...

journal_title：Life sciences

authors： Srivastava AK,Ali W,Singh R,Bhui K,Tyagi S,Al-Khedhairy AA,Srivastava PK,Musarrat J,Shukla Y

更新日期：2012-06-06 00:00:00

abstract：AIMS:Hyperhomocysteinemia (Hhcy) is an independent risk factor of atherosclerosis and promotes unstable plaque formation. Epigenetic mechanisms play an important role in the pathogenesis of atherosclerosis induced by Hhcy. However, the exact mechanism is still undefined. Lesional apoptotic cells and necrotic core forma...

journal_title：Life sciences

authors： Cong G,Yan R,Huang H,Wang K,Yan N,Jin P,Zhang N,Hou J,Chen D,Jia S

更新日期：2017-03-15 00:00:00

abstract：:Chronic administration of narcotic mu opioid agonists results in tolerance and dependence. We propose that agonist stimulation causes a gradual conversion of mu receptors to a constitutively active state (mu*) as a key step in tolerance and physical dependence. We provide evidence in support of the existence of mu* in...

journal_title：Life sciences

authors： Wang Z,Bilsky EJ,Porreca F,Sadée W

更新日期：1994-01-01 00:00:00

abstract：:Although one of the major genes which cause type 1 (insulin-dependent) diabetes mellitus is located in the class II HLA region in humans, its precise location is still unknown. In order to investigate whether TAP (Transporter associated with Antigen Processing) and LMP (Low Molecular Weight Polypeptide) genes, which a...

journal_title：Life sciences

authors： Kawaguchi Y,Ikegami H,Fukuda M,Takekawa K,Fujioka Y,Fujisawa T,Ueda H,Ogihara T

更新日期：1994-01-01 00:00:00

abstract：:A variety of chromatographic approaches are detailed for enhancement of signal and selectivity for determination of biogenic amines by HPLC with amperometric detection. Microbore HPLC columns offer significant signal enhancement due to the reduced elution volume. Selection of novel surfactants such as N-methyl oleoyl ...

journal_title：Life sciences

authors： Mefford IN

更新日期：1987-08-17 00:00:00

abstract：:We studied effects of tyrphostin A23 (an inhibitor of protein tyrosine kinase; PTK) and tyrphostin A63 (an inactive analog of tyrphostin A23) on forskolin-activated cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and Cl(-) secretion in renal epithelial A6 cells. Tyrphostin A23 and A63 had no ...

journal_title：Life sciences

authors： Niisato N,Nishio K,Marunaka Y

更新日期：2002-07-26 00:00:00

abstract：:In fish liver catecholamines bind to beta-adrenoceptors (AR) and increase glucose release via cAMP augmentation. Alpha1-AR have recently been shown to mediate IP3 and Ca2+ elevation in catfish and eel hepatocytes, although their coupling to a physiological response has remained doubtful. We have perifused isolated cat...

journal_title：Life sciences

authors： Fabbri E,Buzzi M,Biondi C,Capuzzo A

更新日期：1999-01-01 00:00:00

abstract：:The potential role of exercise in preventing the age-related spontaneous peripheral neuropathy has not been studied. We examined the effects of long-term aerobic exercise training on lipid peroxidation, Schwann cell (SC) apoptosis and ultrastructural changes in the sciatic nerve of rats during aging. Three groups of 1...

journal_title：Life sciences

authors： Shokouhi G,Tubbs RS,Shoja MM,Roshangar L,Mesgari M,Ghorbanihaghjo A,Ahmadi N,Sheikhzadeh F,Rad JS

更新日期：2008-04-09 00:00:00

abstract：:To study the role of IL-5 in allergic airway hyperreactivity, the time course for the production of cytokines, the infiltration of inflammatory cells and the onset of airway hyperreactivity after three inhalations of antigens were studied in mice. The effect of the soluble alpha-chain of murine recombinant interleukin...

journal_title：Life sciences

authors： Yamaguchi S,Nagai H,Tanaka H,Tsujimoto M,Tsuruoka N

更新日期：1994-01-01 00:00:00

abstract：:It has been reported that nitric oxide (NO) is involved in the relaxation mechanism of ginsenoside saponin in various smooth muscle in experimental animals. Although ginsenoside Rg(3) showed both endothelium-dependent and -independent component relaxation in vascular smooth muscle, the action mechanism of the relaxati...

journal_title：Life sciences

authors： Kang YJ,Sohn JT,Chang KC

更新日期：2005-05-20 00:00:00

abstract：:Three neurodegenerative diseases, Huntington's disease (HD), Kennedy's disease (hereditary spinobulbar muscular atrophy, SBMA), and type 1 spinocerebellar ataxia (SCA-1) have been found to share a common genetic defect: an unstable region of repeated CAG trinucleotides which are thought to be translated into a polyglu...

journal_title：Life sciences

authors： Cha JH,Dure LS 4th

更新日期：1994-01-01 00:00:00

abstract：AIMS:Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its GABAergic activity. Other aromatic alcohols have also been reported as able to protect neurons agains...

journal_title：Life sciences

authors： Delgado-Marín L,Sánchez-Borzone M,García DA

更新日期：2017-04-15 00:00:00