当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Neuroprotective effects of gabaergic phenols correlated with their pharmacological and antioxidant properties.

Neuroprotective effects of gabaergic phenols correlated with their pharmacological and antioxidant properties.

Abstract：

AIMS:Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its GABAergic activity. Other aromatic alcohols have also been reported as able to protect neurons against oxidative damage. The aim of this work is to evaluate the potential neuroprotective effect of some phenols, structurally analogues of propofol, with proven GABAergic activity. These phenols include the naturally occurring compounds thymol, carvacrol and eugenol, the synthetic product chlorothymol, and the most widely used intravenous anesthetic, propofol, as a reference compound. MATERIALS AND METHODS:Taking primary cultures of cortical neurons as a suitable model to evaluate cellular protection against oxidative damage, we developed an injury model to test potential neuroprotective activity. The intracellular hydroperoxides were also determined. KEY FINDINGS:The results showed that no compound decreased cell viability at concentrations where they were active on the GABAA receptor. In neuroprotection tests, some phenols and Vit E showed a partial protective effect against the oxidative injury. These compounds induced a clear tendency to reduce H2O2 damage, comparing production of hydroperoxides, although these last changes were statistically non-significant. SIGNIFICANCE:Testing the intracellular oxidation levels suggests that this partial protection exerted by propofol, thymol and chlorothymol may be mediated in some way by their antioxidant activities. However, this neuroprotection is not completely correlated with the antioxidant capacity, but it approaches their relative pharmacological potency, which could be interpreted as a final effect that would involve both activities.

journal_name

Life Sci

journal_title

Life sciences

authors

Delgado-Marín L,Sánchez-Borzone M,García DA

doi

10.1016/j.lfs.2017.03.005

subject

Has Abstract

pub_date

2017-04-15 00:00:00

pages

11-15

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(17)30088-7

journal_volume

175

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Specificity and sensitivity of S100B levels in amniotic fluid for Down syndrome diagnosis.

    abstract：:Down syndrome (DS) is the most common chromosomal abnormality and is associated with an extra copy of the chromosome 21. Although several markers are commonly used during pregnancy for the screening of DS, the definitive diagnosis is based on karyotype after amniocentesis, which is an expensive and laborious analysis....

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.09.003

    authors： Tort AB,Portela LV,da Purificação Tavares M,Gonçalves CA,Netto C,Giugliani R,Souza DO

    更新日期：2004-12-10 00:00:00

  • Ketamine effects on bupivacaine local anaesthetic activity and pharmacokinetics of bupivacaine in mice.

    abstract：:This study was designed to document possible changes in bupivacaine (B) local anaesthetic activity and pharmacokinetics in mice after a ketamine (K) injection. In the experiments, bupivacaine (8.25 mg.kg(-1)), was injected into the popliteal space of the right posterior limb: the local anaesthetic activity was assesse...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00861-8

    authors： Gantenbein M,Abat C,Attolini L,Pisano P,Emperaire N,Bruguerolle B

    更新日期：1997-01-01 00:00:00

  • Activation of estrogen receptor α (ERα) is required for Alisol B23-acetate to prevent post-menopausal atherosclerosis and reduced lipid accumulation.

    abstract：:The risk of atherosclerosis (AS) ascends among post-menopausal women, while current hormone replacement therapy exerts several adverse effects. Alisol B 23-acetate (AB23A), a tetracyclic triterpenoid isolated from the rhizome of Alisma orientale, was reported to show multiple physiological activities, including regula...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118030

    authors： Chen Q,Chao Y,Zhang W,Zhang Y,Bi Y,Fu Y,Cai D,Meng Q,Li Y,Bian H

    更新日期：2020-10-01 00:00:00

  • Bilirubin in metabolic syndrome and associated inflammatory diseases: New perspectives.

    abstract：:Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.118032

    authors： Novák P,Jackson AO,Zhao GJ,Yin K

    更新日期：2020-09-15 00:00:00

  • Is the brain histamine involved in cataleptogenic action of analgesics and haloperidol?

    abstract：:L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol. ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90580-5

    authors： Malec D,Langwiński R

    更新日期：1983-01-01 00:00:00

  • GPER agonist dilates mesenteric arteries via PI3K-Akt-eNOS and potassium channels in both sexes.

    abstract：AIM:The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.06.020

    authors： Peixoto P,Aires RD,Lemos VS,Bissoli NS,Santos RLD

    更新日期：2017-08-15 00:00:00

  • Affinity chromatography for human Na+, K+-ATPase inhibitors in plasma and urine.

    abstract：:Semi-purified dog kidney Na+,K+-ATPase cross-linked with ovalbumin was used in batch-wise affinity chromatography for the detection of endogenous Na+,K+-ATPase inhibitor in human plasma and urine. Ammonium acetate 1 M washed off the endogenous inhibitor from the immobilized enzyme. The inhibitory activity of the eluat...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90562-4

    authors： Henning G,Cloix JF,Wainer IW,Pernollet MG,Devynck MA,Meyer P

    更新日期：1985-05-06 00:00:00

  • Ontogenesis of nicotinic acetylcholine receptors and presynaptic cholinergic neurons in mammalian brain.

    abstract：:We find a significantly lower level of specific [3H]nicotine binding in the fetal rat forebrain of 20 day gestational age as compared to adult rat tissue, and a progressive increase in the [3H]nicotine binding in the early neonatal forebrain, reaching adult level at 14-28 days of age. The maximal binding sites (Bmax) ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90057-3

    authors： Yamada S,Kagawa Y,Isogai M,Takayanagi N,Hayashi E

    更新日期：1986-02-17 00:00:00

  • Selective inhibition of cardiac cyclic nucleotide phosphodiesterases by doxorubicin and daunorubicin.

    abstract：:Doxorubicin and daunorubicin, the anthracycline antitumor agents, were evaluated for their in vitro and in vivo effect on phosphodiesterase (PDE) activity in mouse tissues. Doxorubicin at a concentration of 10(-4)M inhibited cardiac c-AMP (adenosine 3',5', monophosphate) PDE activity 50% of the control whereas in lung...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90641-1

    authors： Law J,Fumagalli A,Schein PS,Rahman A

    更新日期：1985-02-11 00:00:00

  • Oral resveratrol supplementation improves Metabolic Syndrome features in obese patients submitted to a lifestyle-changing program.

    abstract：AIMS:The aim of the present study was to evaluate the oral resveratrol effects associated with diet and physical training changes on anthropometric and biochemical parameters. MAIN METHODS:25 individuals aged from 30 to 60 years old; with Body Mass Index (BMI) ≥ 30 kg/m2 were included in the study. Following the prima...

    journal_title：Life sciences

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.lfs.2020.117962

    authors： Batista-Jorge GC,Barcala-Jorge AS,Silveira MF,Lelis DF,Andrade JMO,de Paula AMB,Guimarães ALS,Santos SHS

    更新日期：2020-09-01 00:00:00

  • Phospholipid liposomes and prolactin secretion: effects on spontaneous and drug-induced hyperprolactinaemia.

    abstract：:Bovine brain phospholipid liposomes (BC-PL) reduce plasma prolactin (PRL) levels in humans after acute administration and counteract the metoclopramide- and sulpiride-induced hyperprolactinaemia. However, BC-PL, like nomifensine, a dopamine (DA) reuptake inhibitor and therefore an indirect dopaminergic compound, does ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90395-2

    authors： Falaschi P,Rocco A,D'Urso R,Jellamo R,Toffano I,Frajese G

    更新日期：1982-07-05 00:00:00

  • Enzymatic activity and distribution of phospholipase A2 in human cartilage.

    abstract：:Extracellular phospholipase A2 (PLA2) with proinflammatory activity has recently been discovered in synovial fluids in inflammatory arthritides. In the search for the sources of synovial fluid PLA2, human synovium and articular cartilage were found to contain large quantities of the enzyme. In rheumatoid arthritis (RA...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90381-k

    authors： Pruzanski W,Bogoch E,Stefanski E,Wloch M,Vadas P

    更新日期：1991-01-01 00:00:00

  • 2-O-methyl PAF as a Ca2+ mobilizer in Madin Darby canine kidney cells.

    abstract：:In Madin-Darby canine kidney (MDCK) cells, the effect of 2-O-methyl PAF, an inactive analogue of platelet activating factor (PAF), on intracellular Ca2+ concentration ([Ca2+]i) was measured by using the Ca2+-sensitive fluorescent dye fura-2. 2-O-methyl PAF (> or = 15 microM) caused a rapid rise of [Ca2+]i in a concent...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.10.064

    authors： Yeh JH,Huang CJ,Lee JH,Hsu SS,Chen JS,Cheng HH,Chang HT,Huang JK,Chung HM,Mei-Yin Y,Jan CR

    更新日期：2005-06-03 00:00:00

  • Cross tolerance between morphine and beta-endorphin in the in vivo vasodilating effect in the hamster cheek pouch.

    abstract：:The relative potencies of the in vivo vasodilating effect on the arterioles of the hamster cheek pouch of morphine and beta-endorphin decreased significantly after chronic morphine injection, indicating the existence of tolerance to morphine and cross tolerance between morphine and beta-endorphin. The apparent pA2 val...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90140-6

    authors： Koo A,Wong TM

    更新日期：1983-01-31 00:00:00

  • Serum S100B is a useful surrogate marker for long-term outcomes in photochemically-induced thrombotic stroke rat models.

    abstract：:In recent years, serum S100B has been used as a secondary endpoint in some clinical trials, in which serum S100B has successfully indicated the benefits or harm done by the tested agents. Compared to clinical stroke studies, few experimental stroke studies report using serum S100B as a surrogate marker for estimating ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.06.031

    authors： Tanaka Y,Koizumi C,Marumo T,Omura T,Yoshida S

    更新日期：2007-08-02 00:00:00

  • Neurotensin: dual roles in psychostimulant and antipsychotic drug responses.

    abstract：:Central administration of neurotensin (NT) results in a variety of neurobehavioral effects which, depending upon the administration site, resemble the effects of antipsychotic drugs (APDs) and psychostimulants. All clinically effective APDs exhibit significant affinities for dopamine D(2) receptors, supporting the hyp...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/s0024-3205(03)00411-9

    authors： Dobner PR,Deutch AY,Fadel J

    更新日期：2003-06-27 00:00:00

  • Overexpression of PURPL and downregulation of NONHSAT062994 as potential biomarkers in gastric cancer.

    abstract：AIMS:Long non-coding RNAs (LncRNAs) play central roles in the formation and development of gastric cancer (GC). The aim of this study was to evaluate the expression of PURPL and NONHSAT062994 and the relationship between their expressions with clinical characteristics in GC. MAIN METHODS:PURPL and NONHSAT062994 LncRNA...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116904

    authors： Moridi H,Karimi J,Tavilani H,Khodadadi I,Emami Razavi AN

    更新日期：2019-11-15 00:00:00

  • MAPK (ERK2) kinase--a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth.

    abstract：UNLABELLED:Limited clinical and experimental studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit gastric cancer growth. However, the mechanisms involved are not completely understood and cannot be explained by COX-2 inhibition alone. MAPK signaling pathway is essential for cell proliferation...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01411-4

    authors： Husain SS,Szabo IL,Pai R,Soreghan B,Jones MK,Tarnawski AS

    更新日期：2001-11-09 00:00:00

  • Implication of adenosine A2A receptors in hypotension-induced vasodilation and cerebral blood flow autoregulation in rat pial arteries.

    abstract：:This study aimed to evaluate the role for adenosine A2A receptors in the autoregulatory vasodilation to hypotension in relation with cerebral blood flow (CBF) autoregulation in rat pial arteries. Changes in pial artery diameters were observed directly through a closed cranial window. Vasodilation induced by adenosine ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00737-2

    authors： Shin HK,Park SN,Hong KW

    更新日期：2000-08-11 00:00:00

  • In vivo 31P nuclear magnetic resonance evidence of the salvage effect of ascorbate on the postischemic reperfused rat skeletal muscle.

    abstract：:The effect of 32 mM ascorbate on the time courses of phosphocreatine (PCr), inorganic phosphate (Pi), adenosine triphosphate (ATP) and intracellular pH in rat skeletal muscle during ischemia and reperfusion was investigated in vivo using 31P nuclear magnetic resonance (NMR) spectroscopy. Ascorbate was administered int...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00904-x

    authors： Lagerwall K,Daneryd P,Scherstén T,Soussi B

    更新日期：1995-01-01 00:00:00

  • The appropriate remodeling of extracellular matrix is the key molecular signature in subcutaneous adipose tissue following Roux-en-Y gastric bypass.

    abstract：AIMS:We sought to reveal the key molecular signature in subcutaneous adipose tissue (scAT) following Roux-en-Y gastric bypass (RYGB), through bioinformatics analysis and further verification in vivo. MAIN METHODS:We obtained a transcriptome data of scAT from RYGB and sham-operated rats from the Gene Expression Omnibus...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.12.051

    authors： Chen X,Gong L,Li Q,Hu J,Liu X,Wang Y,Bai J,Ran X,Wu J,Ge Q,Li R,Xiao X,Li X,Zhang J,Wang Z

    更新日期：2019-02-01 00:00:00

  • Modulation of inflammatory and oxidative status by exercise attenuates cardiac morphofunctional remodeling in experimental Chagas cardiomyopathy.

    abstract：AIMS:The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility i...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.03.053

    authors： Novaes RD,Gonçalves RV,Penitente AR,Bozi LH,Neves CA,Maldonado IR,Natali AJ,Talvani A

    更新日期：2016-05-01 00:00:00

  • Does the sedative agent, JM-1232(-) cause QT prolongation with subsequent torsades de pointes?

    abstract：AIMS:JM-1232(-) ((-)-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-phenyl-3,5,6,7-tetrahydrocyclopenta[f] isoindole-1(2H)-one) is a novel isoindoline compound that acts on benzodiazepine receptors. Clinical trials are being conducted to assess its potential clinical use as an intravenous anesthetic or sedative agent. In ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2009.10.002

    authors： Kato R,Watanabe R,Miki H,Ijiri Y,Hayashi T,Tanaka K

    更新日期：2009-11-18 00:00:00

  • Effects of pituitary adenylate-cyclase activating peptide (PACAP) on the rat adrenal secretory activity: preliminary in-vitro studies.

    abstract：:PACAP did not affect secretory activity of dispersed rat adrenocortical cells, but it markedly raised aldosterone (ALDO) and corticosterone (B) production by adrenal slices, containing both medullary and cortical tissues. The secretagogue effects of PACAP were suppressed by PACAP(6-38), a specific competitive antagoni...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)00423-p

    authors： Andreis PG,Malendowicz LK,Belloni AS,Nussdorfer GG

    更新日期：1995-01-01 00:00:00

  • Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes.

    abstract：:Short-chain fatty acids (SCFA) are produced by fermentation of water-soluble fiber by anaerobic bacteria in the large bowel. Fiber-rich diets decrease the risk of developing inflammatory bowel disease (IBD) and butyrate enemas are effective as a therapy in some patients. Crohn's disease, one form of IBD, appears to in...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(03)00490-9

    authors： Cavaglieri CR,Nishiyama A,Fernandes LC,Curi R,Miles EA,Calder PC

    更新日期：2003-08-15 00:00:00

  • Actinomycin D inhibition of monoclonal antibody binding to nucleolar phosphoprotein 37/5.2 (B23).

    abstract：:Actinomycin D was found to block binding of a monoclonal antibody to nucleolar phosphoprotein 37/5.2 (B23) when incubated either simultaneously with or prior to addition of the antibody. Daunorubicin had no significant blocking activity of this antigen-antibody reaction. In comparative studies with a monoclonal antibo...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90275-3

    authors： Busch RK,Chan PK,Busch H

    更新日期：1984-10-22 00:00:00

  • Resistance of obese and non-obese, spontaneously hypertensive rats to alloxan-induced diabetes.

    abstract：:Male, 5 months old, massively obese, spontaneously hypertensive rats (Obese/SHR) were given 10 mg alloxan/100 g b.w., s.c., to induce diabetes. Control Obese and non-obese/SHR were given saline. Insulin therapy was withheld. All of the animals were killed at 6 months of age. Alloxan caused a slight but statistically s...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90666-5

    authors： Wexler BC,Mc Murtry JP

    更新日期：1983-09-12 00:00:00

  • Differential effects of spermine on phosphatidylinositol 3-kinase and phosphatidylinositol phosphate 5-kinase.

    abstract：:The metabolism of phosphoinositides plays an important role in the signal transduction pathways. We report here that naturally occurring polyamines affect the activities of phosphatidylinositol (PI) 3-kinase and PI 4-phosphate (PIP) 5-kinase differently. While polyamines inhibited the PI 3-kinase activity, they stimul...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)00320-6

    authors： Singh SS,Chauhan A,Brockerhoff H,Chauhan VP

    更新日期：1995-01-01 00:00:00

  • Sirtuin‑1 protects hair follicle stem cells from TNFα-mediated inflammatory stress via activating the MAPK-ERK-Mfn2 pathway.

    abstract：OBJECTIVE:Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFα-med...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.10.003

    authors： Liu J,Xu Y,Wu Q,Ding Q,Fan W

    更新日期：2018-11-01 00:00:00

  • Relationship between urinary excretion of homovanillic acid and norepinephrine metabolites in normal subjects and patients with orthostatic hypotension.

    abstract：:Patients with neurogenic orthostatic hypotension due to multiple system atrophy (MSA) or pure autonomic failure (PAF) excrete lower amounts of homovanillic acid (HVA) than do normal subjects. There is a highly significant correlation between the rates of excretion of HVA and norepinephrine metabolites. The regression ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90289-5

    authors： Kopin IJ,Oliver JA,Polinsky RJ

    更新日期：1988-01-01 00:00:00