Abstract：
:This study was designed to document possible changes in bupivacaine (B) local anaesthetic activity and pharmacokinetics in mice after a ketamine (K) injection. In the experiments, bupivacaine (8.25 mg.kg(-1)), was injected into the popliteal space of the right posterior limb: the local anaesthetic activity was assessed according to a sciatic nerve blockade method with three different doses (2, 10 and 40 mg/kg) of ketamine and the kinetics were studied after a 10 mg/kg dose. When ketamine was associated, the local anesthetic activity of bupivacaine was significantly enhanced as well as its elimination half-life. Significantly lower levels of the main metabolite, PPX, were observed, when ketamine was associated, suggesting a metabolic inhibition phenomenon. The ketamine-induced increase in the total anaesthetic effect of bupivacaine may thus be explained by kinetic modifications i.e. a possible inhibiting effect of ketamine on the metabolism of bupivacaine.
journal_name
Life Scijournal_title
Life sciencesauthors
Gantenbein M,Abat C,Attolini L,Pisano P,Emperaire N,Bruguerolle Bdoi
10.1016/s0024-3205(97)00861-8subject
Has Abstractpub_date
1997-01-01 00:00:00pages
2027-33issue
20eissn
0024-3205issn
1879-0631pii
S0024320597008618journal_volume
61pub_type
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