Cross stress adaptation: Phenomenon of interactions between homotypic and heterotypic stressors.

abstract：AIMS:Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown. The aim of this study is to determine whether FF treatment reduces insulin resistance (IR) by alleviating ER stress...

journal_title：Life sciences

authors： Dai F,Jiang T,Bao YY,Chen GJ,Chen L,Zhang Q,Lu YX

更新日期：2016-07-15 00:00:00

abstract：:In canine renal tubular cells, the effect of Y-24180, a presumed specific platelet activating factor (PAF) receptor antagonist, on intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured by using fura-2 as a Ca(2+)-sensitive fluorescent probe. Y-24180 (0.1-10 microM) caused a rapid and sustained [Ca(2+)](i) rise...

journal_title：Life sciences

authors： Chao YY,Jan CR

更新日期：2004-01-02 00:00:00

abstract：AIMS:The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)-induced renal tubulointerstitial injury. This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism. MAIN METHODS:Diabetes w...

journal_title：Life sciences

authors： Zha D,Yao T,Bao L,Gao P,Wu X

更新日期：2019-03-15 00:00:00

abstract：:Significant elevation in plasma corticosterone of rats achieved by intraperitoneal (i.p.) administration of corticosterone (2.4 mg/kg) was associated with a rapid (2.5 min) and significant increase in hypothalamic histamine (HA) levels which persisted for 60 min. Midbrain and cortical HA concentrations were not affect...

journal_title：Life sciences

authors： Mazurkiewicz-Kwilecki IM

更新日期：1983-03-07 00:00:00

abstract：:The study of opioid distribution in blood and cerebrospinal fluid (CSF) is required to understand pharmacokinetic-pharmacodynamic relationships following lumbar intrathecal (it) and intracerebroventicular (i.c.v.) administration, and to investigate the contributions of spinal or supraspinal sites of action. The sheep ...

journal_title：Life sciences

authors： Payne R,Gradert TL,Inturrisi CE

更新日期：1996-01-01 00:00:00

abstract：:Previous research has shown that the CAMK (calcium/calmodulin dependent protein kinase) inhibitor, KN62, can lead to reductions in insulin stimulated glucose transport. Although controversial, an L-type calcium channel mechanism has also been hypothesized to be involved in insulin stimulated glucose transport. The pur...

journal_title：Life sciences

authors： Wright DC,Fick CA,Olesen JB,Lim K,Barnes BR,Craig BW

更新日期：2004-01-02 00:00:00

abstract：AIM:Nontuberculous mycobacterial (NTM) infection such as endophthalmitis, dacryocystitis, and canaliculitis are pervasive across the globe and are currently managed by antibiotics. However, the recent cases of Mycobacteroides developing drug resistance reported along with the improper practice of medicine intrigued us ...

journal_title：Life sciences

authors： Satyam R,Bhardwaj T,Jha NK,Jha SK,Nand P

更新日期：2020-06-01 00:00:00

abstract：:The injection of neostigmine into the hippocampus of anesthetized rats increased the mean arterial blood pressure (17% of baseline after 60 min injection) and decreased the heart rate (24% of baseline after 60 min injection). These changes were blocked by the co-administration of methylatropine into the hippocampus. I...

journal_title：Life sciences

authors： Haruta K,Iguchi A,Matsubara T,Itoh K,Chen CL,Yoshida S,Terada R,Kanashiro M,Suzuki O,Nishimura H

更新日期：1992-01-01 00:00:00

abstract：:In order to estimate the intestinal stability of ebiratide [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8-NH2], a novel adrenocorticotropic hormone (ACTH) analogue, after oral administration, the hydrolytic properties of ebiratide were determined in the rat small intestinal fluid and mucosal homogenates. Ebiratide was extr...

journal_title：Life sciences

authors： Okagawa T,Fujita T,Murakami M,Yamamoto A,Shimura T,Tabata S,Kondo S,Muranishi S

更新日期：1994-01-01 00:00:00

abstract：AIMS:This study aims to explore the effect and underlying mechanism of zoledronic acid (ZA) on the incidence of thyroid cancer (TC) tumorigenesis. MATERIALS AND METHODS:Human mononuclear cells THP-1 were differentiated into M2-like tumor associated macrophages (TAMs) by incubation with PMA followed by additional incub...

journal_title：Life sciences

authors： Lv J,Chen FK,Liu C,Liu PJ,Feng ZP,Jia L,Yang ZX,Hou F,Deng ZY

更新日期：2020-09-01 00:00:00

abstract：:Losartan, a recently developed nonpeptide angiotensin II (Ang II) receptor antagonist, was administered orally to 10-week-old spontaneously hypertensive rats (SHR) for 2 weeks. Cardiac weight and tissue Ang II, as well as plasma renin activity (PRA) and Ang II, were determined. Treatment with Losartan (10 mg/kg per da...

journal_title：Life sciences

authors： Mizuno K,Tani M,Hashimoto S,Niimura S,Sanada H,Watanabe H,Ohtsuki M,Fukuchi S

更新日期：1992-01-01 00:00:00

abstract：AIMS:The mechanisms underlying the changes in blood-brain barrier (BBB) integrity and the generation of seizures in childhood associated with preexisting brain lesions like cortical dysplasia (CD) are poorly understood. We investigated the effects of levetiracetam (LEV) on BBB integrity and the survival during hyperthe...

journal_title：Life sciences

authors： Ahishali B,Kaya M,Orhan N,Arican N,Ekizoglu O,Elmas I,Kucuk M,Kemikler G,Kalayci R,Gurses C

更新日期：2010-11-20 00:00:00

abstract：:To determine whether rat retinal photoreceptor cells produce inhibin, a molecule closely related to activin, a multifunctional growth factor in the transforming growth factor beta superfamily (TGF beta), we have conducted immunohistochemistry using specific antibodies for inhibin which were raised against a synthetic ...

journal_title：Life sciences

authors： Ying SY,Li SQ,Zhang Z

更新日期：1995-01-01 00:00:00

abstract：AIMS:Clostridium difficile is an important pathogen in nosocomial infections. Although C. difficile toxins are considered to be major virulence factors, pathogenesis of C. difficile associated diseases remains to be determined. In this study, we investigated whether C. difficile flagellin is involved in the pathogenesi...

journal_title：Life sciences

authors： Yoshino Y,Kitazawa T,Ikeda M,Tatsuno K,Yanagimoto S,Okugawa S,Yotsuyanagi H,Ota Y

更新日期：2013-02-27 00:00:00

abstract：AIMS:The aim of this study was to find out a mesenchymal stem cells (MSCs) source from human dental tissues of the same donor (follicle, papilla and pulp), which exhibits higher neurogenic differentiation potential in vitro. MAIN METHODS:MSCs were isolated from dental tissues (follicle, papilla and pulp) by digestion ...

journal_title：Life sciences

authors： Ullah I,Subbarao RB,Kim EJ,Bharti D,Jang SJ,Park JS,Shivakumar SB,Lee SL,Kang D,Byun JH,Park BW,Rho GJ

更新日期：2016-06-01 00:00:00

abstract：:The effect of thapsigargin, a specific inhibitor of intracellular Ca(2+)-ATPases, on endothelium-dependent relaxation was studied in the guinea pig thoracic aorta. Thapsigargin (1 nM-1 microM) produced a concentration-dependent relaxation of aortic strips precontracted by phenylephrine (0.1 microM) in the presence and...

journal_title：Life sciences

authors： Matsuyama S,Shuntoh H,Katayama S,Tanaka C

更新日期：1993-01-01 00:00:00

abstract：:Malaria is a major health problem in many countries and according to an estimate of the WHO, more than 500 million infections occur per year. Artemisinin, a sesquiterpene from Artemisia annua L., has received considerable attention as a promising and potent antimalarial drug for its stage speciticity, its rather low t...

journal_title：Life sciences

authors： Bilia AR,Lazari D,Messori L,Taglioli V,Temperini C,Vincieri FF

更新日期：2002-01-04 00:00:00

abstract：:Sphinganine (SP) pre-treatment potentiated the retinoic acid (RA)-induced (4-96h exposures) differentiation and increase of alkaline phosphatase (ALP) activity. A higher percentage of SP pre-treated cells in RA exposures resembled mature myelocytes or granulocytes; greater increase in ALP activity was observed. In cel...

journal_title：Life sciences

authors： Wei LL,Hui EK,Wei JS,Tzeng WF,Yung BY

更新日期：1993-01-01 00:00:00

abstract：AIMS:A bridging ligand 2,4,6-pyridine tricarboxylic acid (H(3)ptc) and its manganese(II) complex [Mn(Hptc)(phen)(OH)]n(Hptc=2,4,6-pyridine tricarboxylic acid, phen=1,10-phenanthroline) have been synthesized and characterized. MAIN METHODS:The interaction with DNA (HeLa and KB) was carried out by fluorescence spectrum ...

journal_title：Life sciences

authors： Zhu M,He W,Gao E,Lin L,Zhang Y,Dai L,Wang R,Wang B,Wang M

更新日期：2012-04-09 00:00:00

abstract：:Nitric oxide is involved in a countless number of physiological processes and is known to have cytoprotective as well as cytotoxic effects. Increased knowledge about the multifaceted role of nitric oxide in a variety of disease states has led to the design of multiple treatment strategies involving the nitric oxide sy...

journal_title：Life sciences

authors： Grant MK,El-Fakahany EE

更新日期：2004-02-20 00:00:00

abstract：:Effects of PK 11195 and flumazenil on cardiac responses to diazepam, clonazepam and zolpidem were compared. Coronary flow rate was increased at relatively low doses of diazepam and decreased at higher doses. Clonazepam induced a dose-dependent increase, and zolpidem a decrease of coronary flow rate. PK 11195 reduced t...

journal_title：Life sciences

authors： Zeegers A,van Wilgenburg H,Leeuwin RS

更新日期：1998-01-01 00:00:00

abstract：:Immunoreactive- (IR-) somatostatin (SRIF), neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) contents were investigated in the brain of tremor rats with absence-like seizure and spontaneously epileptic rats (SER), which is a genetically defined double-mutant (zi/zi, tm/tm) obtained by mating zitter homozyg...

journal_title：Life sciences

authors： Sadamatsu M,Kanai H,Masui A,Serikawa T,Yamada J,Sasa M,Kato N

更新日期：1995-01-01 00:00:00

abstract：AIMS:There have been recent reports that reconsolidation-based interventions attenuate drug reward memories in rodents. The insular cortex (IC) is an essential part of neural circuits that underlie cue-drug memory reconsolidation. GABAergic interneurons in the IC are a potent control on network excitability and play an...

journal_title：Life sciences

authors： Sun K,Xiao L,Wu Y,Zuo D,Zhang C,Liu S,He Z,Rong S,Wang F,Sun T

更新日期：2020-08-01 00:00:00

abstract：AIMS:To investigate the effects of curcumin on alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease (COPD) and its potential mechanism. MAIN METHODS:The rat COPD model was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Thirty-eigh...

journal_title：Life sciences

authors： Zhang M,Xie Y,Yan R,Shan H,Tang J,Cai Y,Yin J,Chen M,Zhang J,Yang X,Zhang Q,Li Y

更新日期：2016-11-01 00:00:00

abstract：:The growth response of aortic vascular smooth muscle cells (VSMCs) to chronic hypertension includes vascular hypertrophy. We have shown previously that angiotensin II positively regulates the expression of the human vascular smooth muscle (SM) alpha-actin gene. To further expand our understanding of vasoactive peptide...

journal_title：Life sciences

authors： Andrawis NS,Wang E,Abernethy DR

更新日期：1996-01-01 00:00:00

abstract：:Seasonal and diurnal variations in tonic pain reactions were examined in female and male CBA/J mice maintained in a 12/12 dark/light cycle, at controlled temperature and humidity conditions. Animals were injected into the dorsum of one hindpaw with a dilute (20 microl, 1%) formalin solution. Pain-related behaviors wer...

journal_title：Life sciences

authors： Perissin L,Facchin P,Porro CA

更新日期：2003-01-10 00:00:00

abstract：:Preliminary data suggest that amygdalar corticotropin-releasing factor (CRF) is regulated by nicotinic agonists. We sought to confirm and extend these observations by determining the effects of various concentrations of nicotine on CRF messenger RNA expression in the AR-5 immortalized amygdalar cell line. Nicotine pro...

journal_title：Life sciences

authors： Kasckow JW,Regmi A,Sheriff S,Mulchahey J,Geracioti TD Jr

更新日期：1999-01-01 00:00:00

abstract：AIMS:Recent evidence has shown that systemic administration of sulfonylureas and biguanides block the diclofenac-induced antinociception, but not the effect produced by indomethacin. However, there are no reports about the peripheral interaction between analgesics and the biguanides metformin and phenformin. Therefore,...

journal_title：Life sciences

authors： Ortiz MI

更新日期：2012-01-02 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) modulates various events through several different pathways. Many tumor cells are resistant to this cytokine. Pretreatment of these cells with actinomycin D enhances TNF-alpha-induced apoptosis. In the present study, we investigated the mechanism of this enhancement and whether ...

journal_title：Life sciences

authors： Nishida S,Yoshioka S,Kinoshita-Kimoto S,Kotani M,Tsubaki M,Fujii Y,Tomura TT,Irimajiri K

更新日期：2003-12-26 00:00:00

abstract：:The Ca2+ ionophore A23187 (0.2-5 microM) stimulates the phosphorylation of the substrates of protein kinase C (40,000 dalton protein) and myosin light chain kinase (20,000 dalton protein) in the presence or absence of cyclooxygenase inhibitors. In the presence of cyclooxygenase inhibitors or millimolar Ca2+ there is n...

journal_title：Life sciences

authors： Lapetina EG,Reep B,Watson SP

更新日期：1986-08-25 00:00:00