Met-enkephalin, age and anatomy: a microiontophoretic study in the hippocampus.

Abstract:

:Met-enkephalin, administered microiontophoretically, produced a greater increase in firing in cells in area CA 3-4 in the hippocampus of both young and aged Fisher 344 rats than it did in the CA 1 area. Furthermore, the effect of met-enkephalin on neuronal firing rates was not as great in old rats as it was in young rats. Finally, 20-40 nA of met-enkephalin produced an increase in firing in old rats that was equivalent to the difference (2.5 spikes/sec) in baseline firing between old (2.6 spikes/sec) and young rats (5.1 spikes/sec).

journal_name

Life Sci

journal_title

Life sciences

authors

Haigler HJ,Cahill LF,Crager MR,Charles E

doi

10.1016/0024-3205(87)90360-2

subject

Has Abstract

pub_date

1987-01-12 00:00:00

pages

203-13

issue

2

eissn

0024-3205

issn

1879-0631

pii

0024-3205(87)90360-2

journal_volume

40

pub_type

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