Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells.

abstract：:Tobacco smoke exposure has been shown to inhibit brain and platelet MAO B in animals and in humans. Though the mechanism(s) responsible for MAO B inhibition are not known, studies in rodents have shown that nicotine administration does not inhibit brain MAO B. In this study we investigated whether brain MAO B is also ...

journal_title：Life sciences

authors： Fowler JS,Volkow ND,Logan J,Pappas N,King P,MacGregor R,Shea C,Garza V,Gatley SJ

更新日期：1998-01-01 00:00:00

abstract：:Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...

journal_title：Life sciences

authors： Foudin L,Tumbleson ME,Sun AY,Geisler RW,Sun GY

更新日期：1984-02-27 00:00:00

abstract：:Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weigh...

journal_title：Life sciences

authors： Figueroa J,Vijayagopal P,Debata C,Prasad A,Prasad C

更新日期：1999-01-01 00:00:00

abstract：:The multidrug transporter MDR1 (P-glycoprotein)-mediated interaction between digoxin and 29 antihypertensive drugs of various types was examined by using the MDR1 overexpressing LLC-GA5-COL150 cells, which were established by transfecting MDR1 cDNA into porcine kidney epithelial LLC-PK1 cells. These cells construct mo...

journal_title：Life sciences

authors： Takara K,Kakumoto M,Tanigawara Y,Funakoshi J,Sakaeda T,Okumura K

更新日期：2002-02-15 00:00:00

abstract：:The pigeon crop-sac is a well-known target organ of prolactin (PRL). Pukac and Horseman (Endocrinology 114: 1718, 1984) reported that injections of the hormone caused changes in the expression of several specific proteins in that organ. We investigated the possibility that measuring the amounts of three of these prote...

journal_title：Life sciences

authors： Lebovic DI,Nicoll CS

更新日期：1992-01-01 00:00:00

abstract：:Corticotropin releasing factor (CRF), one of the major effectors of stress, plays a major role in the natural course of drug addiction by accelerating the acquisition of psychostimulant self-administration and increasing incentive motivation for the drug itself and for drug-associated stimuli. Stress-induced CRF is al...

journal_title：Life sciences

authors： Corominas M,Roncero C,Casas M

更新日期：2010-01-02 00:00:00

abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...

journal_title：Life sciences

authors： Bastaki S,Aravindhan S,Ahmadpour Saheb N,Afsari Kashani M,Evgenievich Dorofeev A,Karoon Kiani F,Jahandideh H,Beigi Dargani F,Aksoun M,Nikkhoo A,Masjedi A,Mahmoodpoor A,Ahmadi M,Dolati S,Namvar Aghdash S,Jadidi-Niaragh F

更新日期：2021-02-01 00:00:00

abstract：:The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mix...

journal_title：Life sciences

authors： Zhang LH,Longley RE,Koehn FE

更新日期：1997-01-01 00:00:00

abstract：:Specific binding sites for atrial natriuretic peptide (ANP) were identified and characterized in primary cultures of human thyroid cells. Saturation analysis using [125I] alpha rat ANP as the ligand showed a single class of high affinity binding (Kd = 0.2 nM) which was inhibited by atriopeptin I and the alpha -human f...

journal_title：Life sciences

authors： Sellitti DF,Tseng YC,Wartofsky L

更新日期：1989-01-01 00:00:00

abstract：AIMS:The p53 protein, also called guardian of the genome, has a key role in cell cycle regulation. It is activated under stressful circumstances, such as DNA damage which results in permanent arrest or cell death. The protein is disabled in several types of human cancer due to over-expression of the two regulators, Mdm...

journal_title：Life sciences

authors： Golestanian S,Sharifi A,Popowicz GM,Azizian H,Foroumadi A,Szwagierczak A,Holak TA,Amanlou M

更新日期：2016-01-15 00:00:00

abstract：AIMS:Keratinocytes are the predominant cells in the epidermis, exerting their primary role of physical barrier through sophisticated differentiation process. In addition, keratinocytes contribute to the activation of innate immunity, providing the surveillant role against external pathogens. It has been known that chro...

journal_title：Life sciences

authors： Zhou MW,Jiang RH,Kim KD,Lee JH,Kim CD,Yin WT,Lee JH

更新日期：2016-06-15 00:00:00

abstract：:The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min...

journal_title：Life sciences

authors： Cuccheddu T,Floris S,Serra M,Porceddu ML,Sanna E,Biggio G

更新日期：1995-03-10 00:00:00

abstract：:The role of p44/42 mitogen-activated protein kinase (MAPK) in the expression of intercellular adhesion molecule-1 (ICAM-1) in NCI-H292 cells, a human bronchial epithelial cell line, was analyzed. Treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) or interferon-gamm...

journal_title：Life sciences

authors： Shibuya Y,Hirasawa N,Sakai T,Togashi Y,Muramatsu R,Ishii K,Yamashita M,Takayanagi M,Ohuchi K

更新日期：2004-06-11 00:00:00

abstract：:Specific 125I-CCK receptor binding was significantly increased in brain tissue taken from guinea pig or mouse following chronic (2-3 week) daily administration of haloperidol (2-3 mg/kg/day). Scatchard analysis indicated the increase in CCK binding was due to an increased receptor number (B max) with no change in affi...

journal_title：Life sciences

authors： Chang RS,Lotti VJ,Martin GE,Chen TB

更新日期：1983-02-21 00:00:00

abstract：:Pretreatment with a low dose of 3-nitropropionic acid (3-NPA) has been shown to induce ischemic tolerance in the gerbil hippocampus. It is well known that sublethal (2-min) ischemia also induces ischemic tolerance. To investigate the acquisition of ischemic tolerance with 3-NPA, we examined the protein expression afte...

journal_title：Life sciences

authors： Kato K,Shimazaki K,Kamiya T,Amemiya S,Inaba T,Oguro K,Katayama Y

更新日期：2005-10-21 00:00:00

abstract：AIMS:Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health. MAIN METHODS:Using mice, we compared the effects of short (3 days) and long (17 weeks from weaning) feeding p...

journal_title：Life sciences

authors： Tsuchiya M,Niijima-Yaoita F,Yoneda H,Chiba K,Tsuchiya S,Hagiwara Y,Sasaki K,Sugawara S,Endo Y,Tan-No K,Watanabe M

更新日期：2014-05-08 00:00:00

abstract：:The effects of social crowding in rats on nociception and analgesic actions of mu- and kappa-opioid agonists agonist qualitatively different stimuli were examined. Crowding produced higher control thresholds for electroshock and paw pinch pressure but not for noxious heat. Naloxone did not effect shock thresholds in c...

journal_title：Life sciences

authors： Pilcher CW,Browne J

更新日期：1982-09-20 00:00:00

abstract：:The in vivo effect of trazodone on the density of [(3)H]5-HT binding sites and 5-HT(1A) receptors and adenylyl cyclase (AC) response was studied in regions of rat brain. The chronic administration of trazodone (10 mg/Kg body wt, 40 days) resulted in a significant downregulation of [(3)H]5-HT binding sites and 5-HT(1A)...

journal_title：Life sciences

authors： Subhash MN,Srinivas BN,Vinod KY

更新日期：2002-08-16 00:00:00

abstract：:The effects of exposure to ionizing radiation on the nociceptive thresholds of CF-1 mice were examined. Significant increases in thermal response latencies, indicative of analgesia were observed after exposure to either high or low doses of radiation. However, the onset of analgesia occurred significantly more rapidly...

journal_title：Life sciences

authors： Teskey GC,Kavaliers M

更新日期：1984-10-08 00:00:00

abstract：:Gastric ulceration associated with the use of NSAIDs is most frequently observed in elderly women, the same sector of society most likely to be receiving therapy for osteoporosis. As some anti-osteoporosis medications have been suggested to irritate the upper gastrointestinal mucosa, we evaluated the ability of one su...

journal_title：Life sciences

authors： Elliott SN,McKnight W,Davies NM,MacNaughton WK,Wallace JL

更新日期：1998-01-01 00:00:00

abstract：AIMS:The progressive accumulation of beta-amyloid peptide (Abeta), in the form of senile plaques, has been recognized as one of the major causes of Alzheimer's disease (AD) pathology. Increased production of Abeta and the aggregation of Abeta to oligomers have been reported to trigger neurotoxicity, oxidative damage an...

journal_title：Life sciences

authors： Sul D,Kim HS,Lee D,Joo SS,Hwang KW,Park SY

更新日期：2009-02-27 00:00:00

abstract：:Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level depe...

journal_title：Life sciences

authors： Lee JH,Telang FW,Springer CS Jr,Volkow ND

更新日期：2003-08-29 00:00:00

abstract：:Involvement of T-type voltage dependent Ca2+ channels (VDCCs) on morphine antinociception, in the development of tolerance and dependence to morphine, and naloxone-precipitated abstinence syndrome in morphine dependent mice was examined by using mibefradil, a T-type VDCCs blocker. Mice were rendered tolerant and depen...

journal_title：Life sciences

authors： Dogrul A,Zagli U,Tulunay FC

更新日期：2002-06-28 00:00:00

abstract：UNLABELLED:Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS:Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen to bind to nuclear receptors. MATERIALS AND METHODS:In silico screening predicted t...

journal_title：Life sciences

authors： Zloh M,Perez-Diaz N,Tang L,Patel P,Mackenzie LS

更新日期：2016-02-01 00:00:00

abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...

journal_title：Life sciences

authors： Privratsky JR,Newman DK,Newman PJ

更新日期：2010-07-17 00:00:00

abstract：:Indomethacin (0.14-.5 mM concentration) inhibits nitric oxide production in murine peritoneal macrophages. This was evidenced by measuring both nitrite production or 14C-L-citrulline formation. The inhibition was caused by the diminution of de novo inducible nitric oxide synthase production as demonstrated by Western ...

journal_title：Life sciences

authors： Hrabák A,Vercruysse V,Kahán IL,Vray B

更新日期：2001-03-09 00:00:00

abstract：AIMS:Amino acids, especially branched chain amino acids (BCAAs), have important regulatory roles in protein synthesis. Recently studies revealed that BCAAs protect against ischemia/reperfusion (I/R) injury. We studied the signaling pathway and mitochondrial function affecting a cardiac preconditioning of BCAAs. MAIN M...

journal_title：Life sciences

authors： Satomi S,Morio A,Miyoshi H,Nakamura R,Tsutsumi R,Sakaue H,Yasuda T,Saeki N,Tsutsumi YM

更新日期：2020-03-15 00:00:00

abstract：:The effect on thermonociceptive threshold of intrathecally (i.t.) administered angiotensin II (Ang II) was assessed in the rat tail-flick test. Rats were pretreated, 15 min earlier, with i.t. naloxone (opiate antagonist), losartan (Ang II selective antagonist at AT1 receptor) or [Sar1, Leu8] Ang II (non selective Ang ...

journal_title：Life sciences

authors： Toma N,Sgambato V,Couture R

更新日期：1997-01-01 00:00:00

abstract：:The effect of the Type I benzodiazepine (BDZ) receptor agonist, CL 218,872, on convulsions generated by low doses of methyl beta-carboline-3-carboxylic acid ( MBCC ), bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice was examined. Low doses of CL 218,872 enhanced the convulsions produced by all agents excep...

journal_title：Life sciences

authors： Melchior CL,Garrett KM,Tabakoff B

更新日期：1984-05-28 00:00:00

abstract：:Thirty-seven women, aged 31-78 years, on two separate mornings consumed a decaffeinated beverage to which 6 mg caffeine/kg lean body mass or no caffeine were added. Total urine output of water, calcium, magnesium, sodium, chloride, potassium and creatinine increased in the two hours following caffeine ingestion when c...

journal_title：Life sciences

authors： Bergman EA,Massey LK,Wise KJ,Sherrard DJ

更新日期：1990-01-01 00:00:00