Abstract：
:The effects of social crowding in rats on nociception and analgesic actions of mu- and kappa-opioid agonists agonist qualitatively different stimuli were examined. Crowding produced higher control thresholds for electroshock and paw pinch pressure but not for noxious heat. Naloxone did not effect shock thresholds in crowded or noncrowded rats but it produced hyperalgesia in both groups when pressure and heat were the stimuli. Crowding reduced the antinociceptive potency against pressure of kappa- and mu-agonists but the opposite effect was seen with heat. A comparison of the ratios of potencies against pressure and heat indicates that crowding differentially modified kappa- and mu-receptor systems.
journal_name
Life Scijournal_title
Life sciencesauthors
Pilcher CW,Browne Jdoi
10.1016/0024-3205(82)90345-9subject
Has Abstractpub_date
1982-09-20 00:00:00pages
1213-6issue
12-13eissn
0024-3205issn
1879-0631pii
0024-3205(82)90345-9journal_volume
31pub_type
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