Abstract：
:We examined the effect of 7-OH-DPAT on spontaneous locomotor activity that is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity in diabetic mice, but not in nondiabetic mice. When mice were pretreated with of 7-OH-DPAT (0.1 mg/kg), morphine-induced enhanced locomotor activity in nondiabetic mice, but not in diabetic mice, was significantly reduced. Furthermore, 7-OH-DPAT (0.1 mg/kg) significantly attenuated the morphine-induced increase in DA turnover in both nondiabetic and diabetic mice. However, DA turnover was significantly greater in diabetic mice than in nondiabetic mice. Thus, it is likely that the enhanced spontaneous locomotor activity in diabetic mice may be partially related to the down-regulation of D3-receptor-mediated modulation of dopamine release in the limbic area.
journal_name
Life Scijournal_title
Life sciencesauthors
Kamei J,Saitoh Adoi
10.1016/0024-3205(96)00363-3subject
Has Abstractpub_date
1996-01-01 00:00:00pages
773-80issue
9eissn
0024-3205issn
1879-0631pii
0024320596003633journal_volume
59pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The isolated cat superior cervical ganglion (SCG) was labeled in vitro with either 3H-norepinephrine (3H-NE) or 3H-choline and stimulated through its preganglionic trunk. The release of 3H-NE and 3H-acetylcholine (3H-ACh) elicited by the stimulation was measured under control conditions and in the presence of drugs. T...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90371-6
更新日期：1985-04-29 00:00:00
abstract：:Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90811-1
更新日期：1983-03-21 00:00:00
abstract：:Oxymorphazone (at doses of 50-200 mg/kg) was found to be a relatively weak antinociceptive drug in intact frog (Rana esculenta) when acetic acid was used as pain stimulus. Frogs remained analgesic for at least 48 hrs following oxymorphazone (200 mg/kg) administration. The ligand increased the latency of wiping reflex ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90302-0
更新日期：1989-01-01 00:00:00
abstract：:18-Hydroxycorticosterone (18-OHB) is a precursor of aldosterone and is the only corticosteroid, other than aldosterone, that is synthesized predominantly in the zona glomerulosa. Administration of the dopamine antagonist, metoclopramide results in parallel rises in plasma 18-OHB and aldosterone levels without affectin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90157-1
更新日期：1983-12-19 00:00:00
abstract：:Chromogranin A (CgA) is an acidic protein co-released with catecholamines during exocytosis from sympathetic nerve terminals and chromaffin cells. Previous work has demonstrated that large scale perturbations in sympathetic nervous system (SNS) functioning result in corresponding changes in CgA levels in plasma. Littl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90029-o
更新日期：1992-01-01 00:00:00
abstract：:Despite the recent scientific advances made in cancer diagnostics and therapeutics, cancer still remains the second leading cause of death worldwide. Thus, there is a need to identify new potential biomarkers/molecular targets to improve the diagnosis and treatment of cancer patients. In this regard, long non-coding R...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118035
更新日期：2020-09-15 00:00:00
abstract：:After their discovery, the two known cannabinoid receptors, CB(1) and CB(2), have been the focus of research into the cellular signalling mechanisms of cannabinoids. The initial assessment, mainly derived from expression studies, was that cannabinoids, via G(i/o) proteins, negatively modulate cyclic AMP levels, and ac...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2005.05.055
更新日期：2006-01-02 00:00:00
abstract：:Elevated total homocysteine concentrations and obesity are both associated with an increased risk of cardiovascular disease. However, previous studies of weight reduction on serum homocysteine concentrations have obtained inconsistent reports. We investigated the effect of folic acid supplementation on serum homocyste...
journal_title：Life sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.lfs.2004.12.002
更新日期：2005-03-18 00:00:00
abstract：:Animal studies suggest nicotine and cannabinoids may significantly enhance the therapeutic value of neuroleptics in motor disorders. This was recently demonstrated in humans by the finding that chewing nicotine gum produced striking relief from tics and other symptoms of Tourette syndrome not controlled by neuroleptic...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(89)90444-x
更新日期：1989-01-01 00:00:00
abstract：:Several serotonin (5-HT) receptor antagonists with varying specificities for the 5-HT receptor types, were studied with regard to their effects on blood glucose levels in mice. The non-selective antagonists, metergoline and methysergide, proved to be hyperglycemic at doses commonly used to antagonize 5-HT receptors. I...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90023-5
更新日期：1991-01-01 00:00:00
abstract：:In order to understand the mechanism of increasing body fat in perimenopausal and postmenopausal women, an ovariectomy-induced obesity model was used to study the role of leptin. In this investigation, a long-term study lasted for 13 weeks was conducted to monitoring the change of serum leptin level in rats after the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00181-2
更新日期：1999-01-01 00:00:00
abstract：:In some cell systems muscarinic receptor stimulation can induce proliferation or transformation. This phenomenon is subtype-specific (only m1 and m3 receptors are effective) and cell type dependent. In 1321N1 astrocytoma cells activation of m3 receptors stimulates phospholipase C, but does not induce DNA synthesis. In...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:Alpha-lipoic acid (ALA), a potent biological antioxidant, improves insulin action of skeletal muscle glucose transport and metabolism in both human and animal models of insulin resistance. In order to obtain further insight into the potential intracellular mechanisms for the action of ALA on insulin-stimulated glucose...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00562-6
更新日期：1997-01-01 00:00:00
abstract：:We recently labeled with carbon-11, a high affinity, selective, 5-HT3 receptor (5-HT3R) ligand, S21007, for potential positron emission tomography (PET) applications. To evaluate the in vivo binding properties of [11C]S21007, its brain regional distribution, tissue and plasma pharmacokinetics and plasma metabolisation...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01058-8
更新日期：1998-01-01 00:00:00
abstract：:Activated hepatic stellate cells (HSC; lipocytes; Ito cells) proliferate and are responsible for extracellular matrix synthesis during hepatic fibrogenesis. During activation, HSC undergo transdifferentiation into myofibroblasts expressing alpha-smooth muscle actin (alpha-SMA). Adenosine 3', 5'-cyclic monophosphate (c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00157-5
更新日期：1999-01-01 00:00:00
abstract：:In a partially depolarized guinea pig papillary muscle preparation, BAY K8644 stimulated voltage-operated calcium channels, promoting slow action potentials; this effect was dose-dependent over a concentration range of 3 X 10(-7) M to 3 X 10(-6) M. Isoproterenol and histamine also induced slow action potentials by sti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90651-x
更新日期：1986-07-28 00:00:00
abstract：:In this study we examined if sleep time, caloric intake and energy expenditure are important contributors to development of ovariectomy-induced obesity in mice fed control or high fat diet (HFD). Twelve female mice at 6 weeks of age were divided into 2 groups: Sham (n = 5) and ovariectomized (OVX, n = 7). Mice were fe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.09.034
更新日期：2018-11-01 00:00:00
abstract：:The stability of epidermal growth factor (EGF) in the gastrointestinal humen of 3-day-old suckling and 45-day-old weaned pigs was examined by incubating iodine labeled recombinant human EGF (hEGF) in the gastrointestinal fluids at 37 degrees C and monitoring the generation of acid soluble radioactivity. Chromatographi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00285-8
更新日期：1996-01-01 00:00:00
abstract：:Chronic administration of narcotic mu opioid agonists results in tolerance and dependence. We propose that agonist stimulation causes a gradual conversion of mu receptors to a constitutively active state (mu*) as a key step in tolerance and physical dependence. We provide evidence in support of the existence of mu* in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90022-1
更新日期：1994-01-01 00:00:00
abstract：:This investigation was designed to determine whether St. John's wort (SJW)(435 mg/kg/d), a readily available antidepressant, or its purported active constituents hypericin (1 mg/kg/d) and hyperforin (10 mg/kg/d) were able to induce various hepatic cytochrome P450 (CYP450) isoforms. SJW, hypericin and hyperforin were a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01499-0
更新日期：2002-02-01 00:00:00
abstract：AIMS:Porcelain-fused-to-metal (PFM) crowns are a standard restoration technique in dentistry, but toxicity of PFM in vivo has not been systematically evaluated. The present study evaluated the effects of various metal alloy shells of PFM crowns on the development of zebrafish embryos and larvae in order to determine th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.04.019
更新日期：2018-06-15 00:00:00
abstract：:The purpose of this study was to characterize behavioral interactions between glutamatergic and serotonergic 5-HT2 receptors. Both competitive (AP-5 [D-2-amino-5-phosphovalerate] and D-CPP [3-(2carboxypiperazine-4yl)-propylphosphonate]) and noncompetitive (MK-801 [dizocilpine], ketamine, dextrorphan and dextromethorph...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00519-0
更新日期：1998-01-01 00:00:00
abstract：:We have developed and utilized a photoaffinity probe to identify the adenosine transporter in cardiac sarcolemmal (SL) vesicles. The probe is an azidosalicylate derivative of adenosine made by reacting adenosine with N-hydroxysuccinimidyl-4-azidosalicylic acid (NHS-ASA). Following synthesis and radiolabeling of the pr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00268-b
更新日期：1995-01-01 00:00:00
abstract：:The actions of insulin-like growth factor I (IGF-I) and growth hormone (GH) on lipid metabolism have been investigated in hormonally intact rats. The subcutaneous injection of IGF-I (100 micrograms) and GH (100 micrograms) lowered total cholesterol plasma levels. The in vitro assays on isolated rat adipocytes showed a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02067-s
更新日期：1995-01-01 00:00:00
abstract：:Hydrolysis of fragments of the C-terminal and mid-portions of parathyroid hormone (PTH) by a phosphoramidon-insensitive metallo-endopeptidase, previously purified by us from the microvillar membranes of rat kidney, and by the microvillar membranes of rat kidney themselves were investigated using a reverse-phase HPLC, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00795-0
更新日期：1994-01-01 00:00:00
abstract：AIMS:Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.02.036
更新日期：2019-04-01 00:00:00
abstract：:The effect of polyamines on the catalytic domain of protein kinase C from rat brain was investigated. It was found that the addition of spermine strongly inhibited phosphorylation activity toward histone H1 as substrate. This tetramine, at millimolar concentrations, was most potently effective while triamines and diam...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90382-7
更新日期：1988-01-01 00:00:00
abstract：:Relationship between in vivo down-regulation of cardiac muscarinic receptors and changes in their encoding mRNA was investigated. Rats were treated either once or for ten days with an irreversible inhibitor of acetylcholinesterase, followed by measurements of cardiac acetylcholinesterase, the density and affinity of m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90615-i
更新日期：1991-01-01 00:00:00
abstract：:Central administration of the selective mu opioid agonist, dermorphin, produces a concurrent diuretic and antinatriuretic response in conscious rats. To determine whether central mu opioids differentially affect the renal excretion of water and sodium, we examined changes in renal function produced by intracerebrovent...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00065-e
更新日期：1995-01-01 00:00:00
abstract：:There is now some evidence that i) the availability of plasma tryptophan, the precursor of serotonin, is significantly lower in pregnant women at the end of term and the first few days after delivery than in nonpregnant women; and ii) both pregnancy and the early puerperium are accompanied by activation of the inflamm...
journal_title：Life sciences
pub_type： 临床试验,杂志文章
doi：10.1016/s0024-3205(02)01853-2
更新日期：2002-09-06 00:00:00
