Abstract：
:Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these agents are additive since it was possible for each to neutralize the effects of the other when given in combination. In these experiments, the purine salvage pathway was responsible for over ten times the superoxide production attributable to the NADPH oxidase system.
journal_name
Life Scijournal_title
Life sciencesauthors
Tritsch GL,Niswander PWdoi
10.1016/0024-3205(83)90811-1subject
Has Abstractpub_date
1983-03-21 00:00:00pages
1359-62issue
12eissn
0024-3205issn
1879-0631pii
0024-3205(83)90811-1journal_volume
32pub_type
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